Chlorine in PDB 2c5w: Penicillin-Binding Protein 1A (Pbp-1A) Acyl-Enzyme Complex (Cefotaxime) From Streptococcus Pneumoniae

The structure of Penicillin-Binding Protein 1A (Pbp-1A) Acyl-Enzyme Complex (Cefotaxime) From Streptococcus Pneumoniae, PDB code: 2c5w was solved by C.Contreras-Martel, V.Job, A.-M.Di Guilmi, T.Vernet, O.Dideberg, A.Dessen, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	47.07 / 2.55
Space group	C 2 2 21
Cell size a, b, c (Å), α, β, γ (°)	112.376, 183.373, 54.850, 90.00, 90.00, 90.00
R / Rfree (%)	23.4 / 25.5

The structure of Penicillin-Binding Protein 1A (Pbp-1A) Acyl-Enzyme Complex (Cefotaxime) From Streptococcus Pneumoniae also contains other interesting chemical elements:

Zinc

(Zn)

5 atoms

The binding sites of Chlorine atom in the Penicillin-Binding Protein 1A (Pbp-1A) Acyl-Enzyme Complex (Cefotaxime) From Streptococcus Pneumoniae (pdb code 2c5w). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Penicillin-Binding Protein 1A (Pbp-1A) Acyl-Enzyme Complex (Cefotaxime) From Streptococcus Pneumoniae, PDB code: 2c5w:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Penicillin-Binding Protein 1A (Pbp-1A) Acyl-Enzyme Complex (Cefotaxime) From Streptococcus Pneumoniae


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Penicillin-Binding Protein 1A (Pbp-1A) Acyl-Enzyme Complex (Cefotaxime) From Streptococcus Pneumoniae within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl706 b:89.7 occ:1.00 ND2 B:ASN418 3.4 55.5 1.0 CB B:ASN418 4.3 50.9 1.0 CG B:ASN418 4.3 50.8 1.0

Chlorine binding site 2 out of 2 in the Penicillin-Binding Protein 1A (Pbp-1A) Acyl-Enzyme Complex (Cefotaxime) From Streptococcus Pneumoniae


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Penicillin-Binding Protein 1A (Pbp-1A) Acyl-Enzyme Complex (Cefotaxime) From Streptococcus Pneumoniae within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl707 b:68.4 occ:1.00 OD1 B:ASP297 3.6 83.1 1.0 OD2 B:ASP297 3.7 79.9 1.0 CG B:ASP297 4.0 81.6 1.0 CD A:LYS54 4.4 85.2 1.0

C.Contreras-Martel, V.Job, A.-M.Di Guilmi, T.Vernet, O.Dideberg, A.Dessen. Crystal Structure of Penicillin-Binding Protein 1A (PBP1A) Reveals A Mutational Hotspot Implicated in Beta-Lactam Resistance in Streptococcus Pneumoniae. J.Mol.Biol. V. 355 684 2006.
ISSN: ISSN 0022-2836
PubMed: 16316661
DOI: 10.1016/J.JMB.2005.10.030