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Chlorine in PDB 2c6c: Membrane-Bound Glutamate Carboxypeptidase II (Gcpii) in Complex with Gpi-18431 (S)-2-(4-Iodobenzylphosphonomethyl)-Pentanedioic Acid

Enzymatic activity of Membrane-Bound Glutamate Carboxypeptidase II (Gcpii) in Complex with Gpi-18431 (S)-2-(4-Iodobenzylphosphonomethyl)-Pentanedioic Acid

All present enzymatic activity of Membrane-Bound Glutamate Carboxypeptidase II (Gcpii) in Complex with Gpi-18431 (S)-2-(4-Iodobenzylphosphonomethyl)-Pentanedioic Acid:
3.4.17.21;

Protein crystallography data

The structure of Membrane-Bound Glutamate Carboxypeptidase II (Gcpii) in Complex with Gpi-18431 (S)-2-(4-Iodobenzylphosphonomethyl)-Pentanedioic Acid, PDB code: 2c6c was solved by J.R.Mesters, C.Barinka, W.Li, T.Tsukamoto, P.Majer, B.S.Slusher, J.Konvalinka, R.Hilgenfeld, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 25.00 / 2.00
Space group I 2 2 2
Cell size a, b, c (Å), α, β, γ (°) 103.127, 131.189, 161.225, 90.00, 90.00, 90.00
R / Rfree (%) 19 / 22.5

Other elements in 2c6c:

The structure of Membrane-Bound Glutamate Carboxypeptidase II (Gcpii) in Complex with Gpi-18431 (S)-2-(4-Iodobenzylphosphonomethyl)-Pentanedioic Acid also contains other interesting chemical elements:

Iodine (I) 1 atom
Calcium (Ca) 1 atom
Zinc (Zn) 2 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Membrane-Bound Glutamate Carboxypeptidase II (Gcpii) in Complex with Gpi-18431 (S)-2-(4-Iodobenzylphosphonomethyl)-Pentanedioic Acid (pdb code 2c6c). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Membrane-Bound Glutamate Carboxypeptidase II (Gcpii) in Complex with Gpi-18431 (S)-2-(4-Iodobenzylphosphonomethyl)-Pentanedioic Acid, PDB code: 2c6c:

Chlorine binding site 1 out of 1 in 2c6c

Go back to Chlorine Binding Sites List in 2c6c
Chlorine binding site 1 out of 1 in the Membrane-Bound Glutamate Carboxypeptidase II (Gcpii) in Complex with Gpi-18431 (S)-2-(4-Iodobenzylphosphonomethyl)-Pentanedioic Acid


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Membrane-Bound Glutamate Carboxypeptidase II (Gcpii) in Complex with Gpi-18431 (S)-2-(4-Iodobenzylphosphonomethyl)-Pentanedioic Acid within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl1754

b:27.8
occ:1.00
 O A:HOH2091 3.1 27.2 1.0
O A:HOH2093 3.1 29.2 1.0
ND2 A:ASN451 3.3 22.6 1.0
NE A:ARG534 3.4 41.9 1.0
N A:ASP453 3.4 22.7 1.0
NH2 A:ARG534 3.5 40.2 1.0
CB A:ARG534 3.7 28.9 1.0
CB A:ASP453 3.9 22.4 1.0
CZ A:ARG534 3.9 41.6 1.0
NH2 A:ARG580 3.9 24.4 1.0
CB A:ASN451 4.1 22.2 1.0
CA A:ASP453 4.1 23.0 1.0
N A:ALA452 4.1 23.3 1.0
C A:ASN451 4.2 24.4 1.0
CG A:ASN451 4.2 21.1 1.0
CA A:ALA452 4.3 25.2 1.0
C A:ALA452 4.3 23.7 1.0
O A:ASN451 4.3 24.8 1.0
CD A:ARG534 4.4 37.5 1.0
C A:ASP453 4.4 25.3 1.0
O A:ASP453 4.4 25.6 1.0
CG A:ARG534 4.5 32.6 1.0
O A:ALA535 4.7 25.6 1.0
CZ A:ARG580 4.8 25.5 1.0
CA A:ASN451 4.8 22.2 1.0
CA A:ARG534 4.8 26.6 1.0
N A:ALA535 4.8 26.7 1.0
O A:SER454 4.8 22.4 1.0

Reference:

J.R.Mesters, C.Barinka, W.Li, T.Tsukamoto, P.Majer, B.S.Slusher, J.Konvalinka, R.Hilgenfeld. Structure of Glutamate Carboxypeptidase II, A Drug Target in Neuronal Damage and Prostate Cancer. Embo J. V. 25 1375 2006.
ISSN: ISSN 0261-4189
PubMed: 16467855
DOI: 10.1038/SJ.EMBOJ.7600969
Page generated: Sat Jul 20 06:11:50 2024

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