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Chlorine in PDB 2c6g: Membrane-Bound Glutamate Carboxypeptidase II (Gcpii) with Bound Glutamate

Enzymatic activity of Membrane-Bound Glutamate Carboxypeptidase II (Gcpii) with Bound Glutamate

All present enzymatic activity of Membrane-Bound Glutamate Carboxypeptidase II (Gcpii) with Bound Glutamate:
3.4.17.21;

Protein crystallography data

The structure of Membrane-Bound Glutamate Carboxypeptidase II (Gcpii) with Bound Glutamate, PDB code: 2c6g was solved by J.R.Mesters, C.Barinka, W.Li, T.Tsukamoto, P.Majer, B.S.Slusher, J.Konvalinka, R.Hilgenfeld, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 100.00 / 2.20
Space group I 2 2 2
Cell size a, b, c (Å), α, β, γ (°) 102.435, 130.428, 159.775, 90.00, 90.00, 90.00
R / Rfree (%) 18.6 / 22.8

Other elements in 2c6g:

The structure of Membrane-Bound Glutamate Carboxypeptidase II (Gcpii) with Bound Glutamate also contains other interesting chemical elements:

Calcium (Ca) 1 atom
Zinc (Zn) 2 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Membrane-Bound Glutamate Carboxypeptidase II (Gcpii) with Bound Glutamate (pdb code 2c6g). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Membrane-Bound Glutamate Carboxypeptidase II (Gcpii) with Bound Glutamate, PDB code: 2c6g:

Chlorine binding site 1 out of 1 in 2c6g

Go back to Chlorine Binding Sites List in 2c6g
Chlorine binding site 1 out of 1 in the Membrane-Bound Glutamate Carboxypeptidase II (Gcpii) with Bound Glutamate


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Membrane-Bound Glutamate Carboxypeptidase II (Gcpii) with Bound Glutamate within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl1754

b:31.7
occ:1.00
 O A:HOH2067 3.0 29.3 1.0
N A:ASP453 3.4 24.7 1.0
NE A:ARG534 3.4 34.9 1.0
ND2 A:ASN451 3.4 19.8 1.0
NH2 A:ARG534 3.4 31.3 1.0
O A:HOH2069 3.6 40.5 1.0
CB A:ASP453 3.7 25.1 1.0
CB A:ARG534 3.8 27.3 1.0
CZ A:ARG534 3.9 32.5 1.0
NH2 A:ARG580 3.9 24.5 1.0
CA A:ASP453 3.9 25.0 1.0
CB A:ASN451 4.0 23.4 1.0
N A:ALA452 4.0 24.8 1.0
CG A:ASN451 4.1 24.0 1.0
C A:ASN451 4.2 24.6 1.0
C A:ASP453 4.3 25.9 1.0
O A:ASN451 4.3 26.4 1.0
C A:ALA452 4.3 25.3 1.0
CA A:ALA452 4.4 24.8 1.0
O A:ASP453 4.4 25.7 1.0
CG A:ARG534 4.5 28.8 1.0
CD A:ARG534 4.5 31.9 1.0
CD A:ARG536 4.5 49.0 1.0
CZ A:ARG580 4.7 24.9 1.0
O A:SER454 4.7 26.9 1.0
CA A:ASN451 4.8 24.5 1.0
CA A:ARG534 4.8 27.8 1.0
O A:ALA535 4.9 28.5 1.0
N A:SER454 4.9 26.3 1.0
N A:ALA535 4.9 28.8 1.0
NE A:ARG536 5.0 56.8 1.0

Reference:

J.R.Mesters, C.Barinka, W.Li, T.Tsukamoto, P.Majer, B.S.Slusher, J.Konvalinka, R.Hilgenfeld. Structure of Glutamate Carboxypeptidase II, A Drug Target in Neuronal Damage and Prostate Cancer. Embo J. V. 25 1375 2006.
ISSN: ISSN 0261-4189
PubMed: 16467855
DOI: 10.1038/SJ.EMBOJ.7600969
Page generated: Sat Dec 12 09:01:54 2020

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