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Chlorine in PDB 2c6p: Membrane-Bound Glutamate Carboxypeptidase II (Gcpii) in Complex with Phosphate Anion

Enzymatic activity of Membrane-Bound Glutamate Carboxypeptidase II (Gcpii) in Complex with Phosphate Anion

All present enzymatic activity of Membrane-Bound Glutamate Carboxypeptidase II (Gcpii) in Complex with Phosphate Anion:
3.4.17.21;

Protein crystallography data

The structure of Membrane-Bound Glutamate Carboxypeptidase II (Gcpii) in Complex with Phosphate Anion, PDB code: 2c6p was solved by J.R.Mesters, C.Barinka, W.Li, T.Tsukamoto, P.Majer, B.S.Slusher, J.Konvalinka, R.Hilgenfeld, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 47.14 / 2.39
Space group I 2 2 2
Cell size a, b, c (Å), α, β, γ (°) 102.573, 130.365, 159.414, 90.00, 90.00, 90.00
R / Rfree (%) 19.8 / 25.1

Other elements in 2c6p:

The structure of Membrane-Bound Glutamate Carboxypeptidase II (Gcpii) in Complex with Phosphate Anion also contains other interesting chemical elements:

Calcium (Ca) 1 atom
Zinc (Zn) 2 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Membrane-Bound Glutamate Carboxypeptidase II (Gcpii) in Complex with Phosphate Anion (pdb code 2c6p). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Membrane-Bound Glutamate Carboxypeptidase II (Gcpii) in Complex with Phosphate Anion, PDB code: 2c6p:

Chlorine binding site 1 out of 1 in 2c6p

Go back to Chlorine Binding Sites List in 2c6p
Chlorine binding site 1 out of 1 in the Membrane-Bound Glutamate Carboxypeptidase II (Gcpii) in Complex with Phosphate Anion


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Membrane-Bound Glutamate Carboxypeptidase II (Gcpii) in Complex with Phosphate Anion within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl1754

b:35.9
occ:1.00
 O A:HOH2036 3.0 29.4 1.0
NE A:ARG534 3.3 42.4 1.0
N A:ASP453 3.3 30.9 1.0
ND2 A:ASN451 3.4 30.4 1.0
NH2 A:ARG534 3.6 42.3 1.0
O A:HOH2038 3.6 39.5 1.0
CB A:ASP453 3.7 31.3 1.0
CB A:ARG534 3.7 31.5 1.0
NH2 A:ARG580 3.9 29.4 1.0
CA A:ASP453 3.9 31.7 1.0
CZ A:ARG534 3.9 42.5 1.0
CB A:ASN451 4.0 29.1 1.0
N A:ALA452 4.1 30.0 1.0
CG A:ASN451 4.2 29.7 1.0
C A:ASN451 4.2 29.4 1.0
C A:ASP453 4.2 32.6 1.0
C A:ALA452 4.3 30.7 1.0
CA A:ALA452 4.3 30.3 1.0
O A:ASP453 4.3 33.5 1.0
CD A:ARG534 4.4 39.8 1.0
CG A:ARG534 4.4 33.8 1.0
O A:ASN451 4.4 30.0 1.0
O A:SER454 4.6 36.0 1.0
CZ A:ARG580 4.7 31.1 1.0
CA A:ASN451 4.8 29.0 1.0
O A:ALA535 4.8 33.2 1.0
CA A:ARG534 4.8 30.6 1.0
N A:SER454 5.0 33.6 1.0
N A:ALA535 5.0 30.8 1.0

Reference:

J.R.Mesters, C.Barinka, W.Li, T.Tsukamoto, P.Majer, B.S.Slusher, J.Konvalinka, R.Hilgenfeld. Structure of Glutamate Carboxypeptidase II, A Drug Target in Neuronal Damage and Prostate Cancer. Embo J. V. 25 1375 2006.
ISSN: ISSN 0261-4189
PubMed: 16467855
DOI: 10.1038/SJ.EMBOJ.7600969
Page generated: Sat Jul 20 06:12:46 2024

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