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Chlorine in PDB 2cc2: X-Ray Crystal Structure of 5'-Fluorodeoxyadenosine Synthase From Streptomyces Cattleya Complexed with 5'Deoxyadenosine

Enzymatic activity of X-Ray Crystal Structure of 5'-Fluorodeoxyadenosine Synthase From Streptomyces Cattleya Complexed with 5'Deoxyadenosine

All present enzymatic activity of X-Ray Crystal Structure of 5'-Fluorodeoxyadenosine Synthase From Streptomyces Cattleya Complexed with 5'Deoxyadenosine:
2.5.1.63;

Protein crystallography data

The structure of X-Ray Crystal Structure of 5'-Fluorodeoxyadenosine Synthase From Streptomyces Cattleya Complexed with 5'Deoxyadenosine, PDB code: 2cc2 was solved by A.R.Mcewan, H.Deng, R.P.Mcglinchey, D.R.Robinson, D.O'hagan, J.Spencer, J.H.Naismith, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 35.00 / 2.00
Space group C 2 2 21
Cell size a, b, c (Å), α, β, γ (°) 75.990, 129.676, 184.505, 90.00, 90.00, 90.00
R / Rfree (%) 18.7 / 24.9

Chlorine Binding Sites:

The binding sites of Chlorine atom in the X-Ray Crystal Structure of 5'-Fluorodeoxyadenosine Synthase From Streptomyces Cattleya Complexed with 5'Deoxyadenosine (pdb code 2cc2). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the X-Ray Crystal Structure of 5'-Fluorodeoxyadenosine Synthase From Streptomyces Cattleya Complexed with 5'Deoxyadenosine, PDB code: 2cc2:

Chlorine binding site 1 out of 1 in 2cc2

Go back to Chlorine Binding Sites List in 2cc2
Chlorine binding site 1 out of 1 in the X-Ray Crystal Structure of 5'-Fluorodeoxyadenosine Synthase From Streptomyces Cattleya Complexed with 5'Deoxyadenosine


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of X-Ray Crystal Structure of 5'-Fluorodeoxyadenosine Synthase From Streptomyces Cattleya Complexed with 5'Deoxyadenosine within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Cl1299

b:52.7
occ:1.00
 O B:HOH2017 3.3 27.2 1.0
O A:HOH2016 3.3 19.7 1.0
O A:HOH2011 3.3 16.4 1.0
O A:HOH2018 3.4 35.9 1.0
O A:HOH2019 3.7 18.2 1.0
O C:HOH2022 3.9 20.7 1.0
O C:HOH2025 3.9 13.4 1.0
O C:HOH2024 3.9 32.7 1.0
O A:HOH2017 4.1 24.3 1.0
O A:HOH2013 4.3 21.6 1.0
OD2 A:ASP42 4.5 27.4 1.0
OD2 B:ASP42 4.5 25.9 1.0
O B:HOH2011 4.5 21.3 1.0
OD2 C:ASP42 4.7 27.5 1.0
NZ A:LYS28 4.7 24.7 1.0
O B:VAL40 4.9 24.3 1.0
O C:HOH2016 4.9 21.8 1.0

Reference:

S.L.Cobb, H.Deng, A.R.Mcewan, J.H.Naismith, D.O'hagan, D.A.Robinson. Substrate Specificity in Enzymatic Fluorination. the Fluorinase From Streptomyces Cattleya Accepts 2'-Deoxyadenosine Substrates. Org. Biomol. Chem. V. 4 1458 2006.
ISSN: ISSN 1477-0520
PubMed: 16604208
DOI: 10.1039/B600574H
Page generated: Sat Dec 12 09:02:05 2020

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