Chlorine in PDB 2cgf: A Radicicol Analogue Bound to the Atp Binding Site of the N- Terminal Domain of the Yeast HSP90 Chaperone

The structure of A Radicicol Analogue Bound to the Atp Binding Site of the N- Terminal Domain of the Yeast HSP90 Chaperone, PDB code: 2cgf was solved by S.M.Roe, C.Prodromou, L.H.Pearl, C.J.Moody, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	73.72 / 2.2
Space group	P 43 2 2
Cell size a, b, c (Å), α, β, γ (°)	73.654, 73.654, 110.733, 90.00, 90.00, 90.00
R / Rfree (%)	16.8 / 20.8

The binding sites of Chlorine atom in the A Radicicol Analogue Bound to the Atp Binding Site of the N- Terminal Domain of the Yeast HSP90 Chaperone (pdb code 2cgf). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the A Radicicol Analogue Bound to the Atp Binding Site of the N- Terminal Domain of the Yeast HSP90 Chaperone, PDB code: 2cgf:

Chlorine binding site 1 out of 1 in the A Radicicol Analogue Bound to the Atp Binding Site of the N- Terminal Domain of the Yeast HSP90 Chaperone


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of A Radicicol Analogue Bound to the Atp Binding Site of the N- Terminal Domain of the Yeast HSP90 Chaperone within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1214 b:12.7 occ:1.00 CL1 A:P2N1214 0.0 12.7 1.0 C6 A:P2N1214 1.8 10.8 1.0 C5 A:P2N1214 2.7 10.4 1.0 C7 A:P2N1214 2.8 10.2 1.0 O4 A:P2N1214 2.9 12.0 1.0 C8 A:P2N1214 3.1 12.6 1.0 CD1 A:PHE124 3.3 6.3 1.0 ND2 A:ASN37 3.4 16.5 1.0 C9 A:P2N1214 3.5 14.4 1.0 CG A:PHE124 3.7 8.7 1.0 CB A:PHE124 3.7 8.2 1.0 C10 A:P2N1214 3.8 11.1 1.0 CD2 A:LEU93 3.9 7.6 1.0 C4 A:P2N1214 4.0 10.2 1.0 C2 A:P2N1214 4.0 11.6 1.0 CE1 A:PHE124 4.1 9.4 1.0 CG A:ASN37 4.2 10.2 1.0 O5 A:P2N1214 4.3 16.5 1.0 CB A:ASN37 4.4 8.3 1.0 C3 A:P2N1214 4.5 10.6 1.0 CD2 A:PHE124 4.6 7.9 1.0 O A:HOH2126 4.7 12.0 1.0 CA A:PHE124 4.8 8.2 1.0 CD1 A:LEU173 4.9 6.2 1.0 CD2 A:LEU173 4.9 6.0 1.0

N.Proisy, S.Y.Sharp, K.Boxall, S.Connelly, S.M.Roe, C.Prodromou, A.M.Z.Slawin, L.H.Pearl, P.Workman, C.J.Moody. Inhibition of HSP90 with Synthetic Macrolactones: Synthesis and Structural and Biological Evaluation of Ring and Conformational Analogs of Radicicol. Chem.Biol. V. 13 1203 2006.
ISSN: ISSN 1074-5521
PubMed: 17114002
DOI: 10.1016/J.CHEMBIOL.2006.09.015