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Chlorine in PDB 2chw: A Pharmacological Map of the PI3-K Family Defines A Role For P110 Alpha in Signaling: the Structure of Complex of Phosphoinositide 3- Kinase Gamma with Inhibitor Pik-39

Enzymatic activity of A Pharmacological Map of the PI3-K Family Defines A Role For P110 Alpha in Signaling: the Structure of Complex of Phosphoinositide 3- Kinase Gamma with Inhibitor Pik-39

All present enzymatic activity of A Pharmacological Map of the PI3-K Family Defines A Role For P110 Alpha in Signaling: the Structure of Complex of Phosphoinositide 3- Kinase Gamma with Inhibitor Pik-39:
2.7.1.137; 2.7.1.153;

Protein crystallography data

The structure of A Pharmacological Map of the PI3-K Family Defines A Role For P110 Alpha in Signaling: the Structure of Complex of Phosphoinositide 3- Kinase Gamma with Inhibitor Pik-39, PDB code: 2chw was solved by Z.A.Knight, B.Gonzalez, M.E.Feldman, E.R.Zunder, D.D.Goldenberg, O.Williams, R.Loewith, D.Stokoe, A.Balla, B.Toth, T.Balla, W.A.Weiss, R.L.Williams, K.M.Shokat, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 62.14 / 2.60
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 143.804, 67.523, 106.311, 90.00, 95.45, 90.00
R / Rfree (%) 23.7 / 29.9

Chlorine Binding Sites:

The binding sites of Chlorine atom in the A Pharmacological Map of the PI3-K Family Defines A Role For P110 Alpha in Signaling: the Structure of Complex of Phosphoinositide 3- Kinase Gamma with Inhibitor Pik-39 (pdb code 2chw). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the A Pharmacological Map of the PI3-K Family Defines A Role For P110 Alpha in Signaling: the Structure of Complex of Phosphoinositide 3- Kinase Gamma with Inhibitor Pik-39, PDB code: 2chw:

Chlorine binding site 1 out of 1 in 2chw

Go back to Chlorine Binding Sites List in 2chw
Chlorine binding site 1 out of 1 in the A Pharmacological Map of the PI3-K Family Defines A Role For P110 Alpha in Signaling: the Structure of Complex of Phosphoinositide 3- Kinase Gamma with Inhibitor Pik-39


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of A Pharmacological Map of the PI3-K Family Defines A Role For P110 Alpha in Signaling: the Structure of Complex of Phosphoinositide 3- Kinase Gamma with Inhibitor Pik-39 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl2093

b:63.5
occ:1.00
 CL A:0392093 0.0 63.5 1.0
CAD A:0392093 1.8 63.1 1.0
CAC A:0392093 2.7 62.5 1.0
OAB A:0392093 2.8 62.8 1.0
CAE A:0392093 2.8 62.9 1.0
CAF A:0392093 3.2 62.6 1.0
C A:VAL803 3.7 64.6 1.0
N A:MET804 3.7 64.7 1.0
O A:VAL803 3.8 64.3 1.0
CA A:MET804 3.8 65.6 1.0
CAK A:0392093 4.0 62.3 1.0
CAM A:0392093 4.1 63.0 1.0
CB A:MET804 4.1 65.6 1.0
CG A:LYS802 4.1 64.6 1.0
CD A:LYS802 4.1 64.2 1.0
CB A:TRP812 4.2 56.3 1.0
CG A:MET804 4.3 66.4 1.0
N A:VAL803 4.4 64.0 1.0
CE3 A:TRP812 4.4 57.9 1.0
CA A:VAL803 4.5 64.3 1.0
CAL A:0392093 4.5 62.9 1.0
NAG A:0392093 4.5 62.6 1.0
NZ A:LYS802 4.6 64.4 1.0
CB A:LYS802 4.6 63.9 1.0
CE A:LYS802 4.7 64.6 1.0
CG A:TRP812 4.7 56.3 1.0
CD2 A:TRP812 4.7 57.2 1.0
C A:LYS802 4.8 63.9 1.0

Reference:

Z.A.Knight, B.Gonzalez, M.E.Feldman, E.R.Zunder, D.D.Goldenberg, O.Williams, R.Loewith, D.Stokoe, A.Balla, B.Toth, T.Balla, W.A.Weiss, R.L.Williams, K.M.Shokat. A Pharmacological Map of the PI3-K Family Defines A Role For P110ALPHA in Signaling Cell(Cambridge,Mass.) V. 125 733 2006.
ISSN: ISSN 0092-8674
PubMed: 16647110
DOI: 10.1016/J.CELL.2006.03.035
Page generated: Sat Jul 20 06:19:45 2024

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