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Chlorine in PDB 2chz: A Pharmacological Map of the PI3-K Family Defines A Role For P110ALPHA in Signaling: the Structure of Complex of Phosphoinositide 3-Kinase Gamma with Inhibitor Pik-93

Enzymatic activity of A Pharmacological Map of the PI3-K Family Defines A Role For P110ALPHA in Signaling: the Structure of Complex of Phosphoinositide 3-Kinase Gamma with Inhibitor Pik-93

All present enzymatic activity of A Pharmacological Map of the PI3-K Family Defines A Role For P110ALPHA in Signaling: the Structure of Complex of Phosphoinositide 3-Kinase Gamma with Inhibitor Pik-93:
2.7.1.137; 2.7.1.153;

Protein crystallography data

The structure of A Pharmacological Map of the PI3-K Family Defines A Role For P110ALPHA in Signaling: the Structure of Complex of Phosphoinositide 3-Kinase Gamma with Inhibitor Pik-93, PDB code: 2chz was solved by Z.A.Knight, B.Gonzalez, M.E.Feldman, E.R.Zunder, D.D.Goldenberg, O.Williams, R.Loewith, D.Stokoe, A.Balla, B.Toth, T.Balla, W.A.Weiss, R.L.Williams, K.M.Shokat, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 71.80 / 2.60
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 144.025, 68.114, 106.351, 90.00, 95.21, 90.00
R / Rfree (%) 24.4 / 30.2

Chlorine Binding Sites:

The binding sites of Chlorine atom in the A Pharmacological Map of the PI3-K Family Defines A Role For P110ALPHA in Signaling: the Structure of Complex of Phosphoinositide 3-Kinase Gamma with Inhibitor Pik-93 (pdb code 2chz). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the A Pharmacological Map of the PI3-K Family Defines A Role For P110ALPHA in Signaling: the Structure of Complex of Phosphoinositide 3-Kinase Gamma with Inhibitor Pik-93, PDB code: 2chz:

Chlorine binding site 1 out of 1 in 2chz

Go back to Chlorine Binding Sites List in 2chz
Chlorine binding site 1 out of 1 in the A Pharmacological Map of the PI3-K Family Defines A Role For P110ALPHA in Signaling: the Structure of Complex of Phosphoinositide 3-Kinase Gamma with Inhibitor Pik-93


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of A Pharmacological Map of the PI3-K Family Defines A Role For P110ALPHA in Signaling: the Structure of Complex of Phosphoinositide 3-Kinase Gamma with Inhibitor Pik-93 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl2093

b:80.1
occ:1.00
 CL A:0932093 0.0 80.1 1.0
CAB A:0932093 1.7 79.2 1.0
CAC A:0932093 2.7 79.2 1.0
CAF A:0932093 2.7 79.1 1.0
NAU A:0932093 3.2 78.6 1.0
SAN A:0932093 3.2 78.8 1.0
OAO A:0932093 3.3 77.5 1.0
CB A:ASP964 3.7 57.2 1.0
CD1 A:ILE879 3.7 62.2 1.0
CA A:ASP964 3.9 57.2 1.0
CG A:ASP964 4.0 59.7 1.0
CAD A:0932093 4.0 79.2 1.0
CAG A:0932093 4.0 79.3 1.0
N A:ASP964 4.0 56.0 1.0
OD1 A:ASP964 4.2 60.9 1.0
CAV A:0932093 4.4 79.8 1.0
CAH A:0932093 4.5 79.2 1.0
OD2 A:ASP964 4.5 61.8 1.0
OAM A:0932093 4.7 78.8 1.0
CAW A:0932093 4.7 80.0 1.0
OH A:TYR867 4.7 42.1 1.0
CD1 A:ILE963 4.9 53.2 1.0

Reference:

Z.A.Knight, B.Gonzalez, M.E.Feldman, E.R.Zunder, D.D.Goldenberg, O.Williams, R.Loewith, D.Stokoe, A.Balla, B.Toth, T.Balla, W.A.Weiss, R.L.Williams, K.M.Shokat. A Pharmacological Map of the PI3-K Family Defines A Role For P110ALPHA in Signaling Cell(Cambridge,Mass.) V. 125 733 2006.
ISSN: ISSN 0092-8674
PubMed: 16647110
DOI: 10.1016/J.CELL.2006.03.035
Page generated: Sat Jul 20 06:20:26 2024

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