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Chlorine in PDB 2dm6: Crystal Structure of Anti-Configuration of Indomethacin and Leukotriene B4 12-Hydroxydehydrogenase/15-Oxo-Prostaglandin 13- Reductase Complex

Enzymatic activity of Crystal Structure of Anti-Configuration of Indomethacin and Leukotriene B4 12-Hydroxydehydrogenase/15-Oxo-Prostaglandin 13- Reductase Complex

All present enzymatic activity of Crystal Structure of Anti-Configuration of Indomethacin and Leukotriene B4 12-Hydroxydehydrogenase/15-Oxo-Prostaglandin 13- Reductase Complex:
1.3.1.48; 1.3.1.74;

Protein crystallography data

The structure of Crystal Structure of Anti-Configuration of Indomethacin and Leukotriene B4 12-Hydroxydehydrogenase/15-Oxo-Prostaglandin 13- Reductase Complex, PDB code: 2dm6 was solved by T.Hori, J.Ishijima, T.Yokomizo, H.Ago, T.Shimizu, M.Miyano, Rikenstructural Genomics/Proteomics Initiative (Rsgi), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 34.16 / 2.00
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 58.253, 76.075, 79.646, 90.00, 102.62, 90.00
R / Rfree (%) 18.1 / 22.4

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Crystal Structure of Anti-Configuration of Indomethacin and Leukotriene B4 12-Hydroxydehydrogenase/15-Oxo-Prostaglandin 13- Reductase Complex (pdb code 2dm6). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of Anti-Configuration of Indomethacin and Leukotriene B4 12-Hydroxydehydrogenase/15-Oxo-Prostaglandin 13- Reductase Complex, PDB code: 2dm6:

Chlorine binding site 1 out of 1 in 2dm6

Go back to Chlorine Binding Sites List in 2dm6
Chlorine binding site 1 out of 1 in the Crystal Structure of Anti-Configuration of Indomethacin and Leukotriene B4 12-Hydroxydehydrogenase/15-Oxo-Prostaglandin 13- Reductase Complex


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Anti-Configuration of Indomethacin and Leukotriene B4 12-Hydroxydehydrogenase/15-Oxo-Prostaglandin 13- Reductase Complex within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl1401

b:43.9
occ:1.00
 CL A:IMN1401 0.0 43.9 1.0
C13 A:IMN1401 1.5 53.0 1.0
C14 A:IMN1401 2.5 51.1 1.0
C12 A:IMN1401 2.5 50.9 1.0
N B:GLU258 3.7 36.4 1.0
CE1 A:TYR245 3.7 30.3 1.0
C15 A:IMN1401 3.8 48.3 1.0
C11 A:IMN1401 3.8 50.5 1.0
CA B:GLU258 3.9 38.4 1.0
CG B:GLU258 3.9 45.5 1.0
C B:PRO257 3.9 35.5 1.0
CD1 B:ILE261 3.9 24.6 1.0
CB B:PRO257 3.9 35.5 1.0
O B:PRO257 4.2 34.4 1.0
OH A:TYR245 4.3 31.9 1.0
C10 A:IMN1401 4.3 54.2 1.0
CZ A:TYR245 4.4 31.1 1.0
CB B:GLU258 4.5 39.2 1.0
CD1 A:TYR245 4.5 27.7 1.0
CA B:PRO257 4.6 36.2 1.0
CB A:ALA241 4.6 29.1 1.0
CE A:MET248 4.8 57.9 1.0
CG B:PRO257 5.0 37.8 1.0

Reference:

T.Hori, J.Ishijima, T.Yokomizo, H.Ago, T.Shimizu, M.Miyano. Crystal Structure of Anti-Configuration of Indomethacin and Leukotriene B4 12-Hydroxydehydrogenase/15-Oxo-Prostaglandin 13-Reductase Complex Reveals the Structural Basis of Broad Spectrum Indomethacin Efficacy J.Biochem.(Tokyo) V. 140 457 2006.
ISSN: ISSN 0021-924X
PubMed: 16916844
DOI: 10.1093/JB/MVJ176
Page generated: Sat Dec 12 09:03:16 2020

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