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Atomistry » Chlorine » PDB 2dxa-2ess » 2ei7 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Chlorine » PDB 2dxa-2ess » 2ei7 » |
Chlorine in PDB 2ei7: Factor Xa in Complex with the Inhibitor Trans-N1-[(5-Chloroindol-2- Yl)Carbonyl]-N2-[(5-Methyl-4,5,6,7-Tetrahydrothiazolo[5,4-C]Pyridin- 2-Yl)Carbonyl]-1,2-CyclohexanediamineEnzymatic activity of Factor Xa in Complex with the Inhibitor Trans-N1-[(5-Chloroindol-2- Yl)Carbonyl]-N2-[(5-Methyl-4,5,6,7-Tetrahydrothiazolo[5,4-C]Pyridin- 2-Yl)Carbonyl]-1,2-Cyclohexanediamine
All present enzymatic activity of Factor Xa in Complex with the Inhibitor Trans-N1-[(5-Chloroindol-2- Yl)Carbonyl]-N2-[(5-Methyl-4,5,6,7-Tetrahydrothiazolo[5,4-C]Pyridin- 2-Yl)Carbonyl]-1,2-Cyclohexanediamine:
3.4.21.6; Protein crystallography data
The structure of Factor Xa in Complex with the Inhibitor Trans-N1-[(5-Chloroindol-2- Yl)Carbonyl]-N2-[(5-Methyl-4,5,6,7-Tetrahydrothiazolo[5,4-C]Pyridin- 2-Yl)Carbonyl]-1,2-Cyclohexanediamine, PDB code: 2ei7
was solved by
M.Suzuki,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 2ei7:
The structure of Factor Xa in Complex with the Inhibitor Trans-N1-[(5-Chloroindol-2- Yl)Carbonyl]-N2-[(5-Methyl-4,5,6,7-Tetrahydrothiazolo[5,4-C]Pyridin- 2-Yl)Carbonyl]-1,2-Cyclohexanediamine also contains other interesting chemical elements:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Factor Xa in Complex with the Inhibitor Trans-N1-[(5-Chloroindol-2- Yl)Carbonyl]-N2-[(5-Methyl-4,5,6,7-Tetrahydrothiazolo[5,4-C]Pyridin- 2-Yl)Carbonyl]-1,2-Cyclohexanediamine
(pdb code 2ei7). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Factor Xa in Complex with the Inhibitor Trans-N1-[(5-Chloroindol-2- Yl)Carbonyl]-N2-[(5-Methyl-4,5,6,7-Tetrahydrothiazolo[5,4-C]Pyridin- 2-Yl)Carbonyl]-1,2-Cyclohexanediamine, PDB code: 2ei7: Chlorine binding site 1 out of 1 in 2ei7Go back to Chlorine Binding Sites List in 2ei7
Chlorine binding site 1 out
of 1 in the Factor Xa in Complex with the Inhibitor Trans-N1-[(5-Chloroindol-2- Yl)Carbonyl]-N2-[(5-Methyl-4,5,6,7-Tetrahydrothiazolo[5,4-C]Pyridin- 2-Yl)Carbonyl]-1,2-Cyclohexanediamine
Mono view Stereo pair view
Reference:
T.Nagata,
T.Yoshino,
N.Haginoya,
K.Yoshikawa,
Y.Isobe,
T.Furugohri,
H.Kanno.
Cycloalkanediamine Derivatives As Novel Blood Coagulation Factor Xa Inhibitors To Be Published.
Page generated: Sat Dec 12 09:03:56 2020
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