Chlorine in PDB 2f35: Crystal Structure of the GLUR5 Ligand Binding Core with UBP302 at 1.87 Angstroms Resolution

The structure of Crystal Structure of the GLUR5 Ligand Binding Core with UBP302 at 1.87 Angstroms Resolution, PDB code: 2f35 was solved by M.L.Mayer, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	38.92 / 1.87
Space group	C 2 2 21
Cell size a, b, c (Å), α, β, γ (°)	97.876, 97.907, 128.347, 90.00, 90.00, 90.00
R / Rfree (%)	19.1 / 22

The binding sites of Chlorine atom in the Crystal Structure of the GLUR5 Ligand Binding Core with UBP302 at 1.87 Angstroms Resolution (pdb code 2f35). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Crystal Structure of the GLUR5 Ligand Binding Core with UBP302 at 1.87 Angstroms Resolution, PDB code: 2f35:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Crystal Structure of the GLUR5 Ligand Binding Core with UBP302 at 1.87 Angstroms Resolution


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of the GLUR5 Ligand Binding Core with UBP302 at 1.87 Angstroms Resolution within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl501 b:24.9 occ:0.50 O A:HOH819 2.8 22.8 1.0 NH1 A:ARG227 3.5 16.9 1.0 NZ A:LYS103 3.7 11.9 1.0 CG A:LYS103 4.0 12.9 1.0 CE A:LYS103 4.1 13.8 1.0 O A:PHE101 4.3 14.6 1.0 CD A:ARG227 4.4 16.0 1.0 OD1 A:ASP228 4.5 17.6 1.0 CZ A:ARG227 4.6 16.5 1.0 CD A:LYS103 4.7 13.3 1.0 OG1 A:THR231 4.8 15.0 1.0 N A:LYS103 4.8 12.5 1.0 NE A:ARG227 5.0 15.3 1.0

Chlorine binding site 2 out of 2 in the Crystal Structure of the GLUR5 Ligand Binding Core with UBP302 at 1.87 Angstroms Resolution


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of the GLUR5 Ligand Binding Core with UBP302 at 1.87 Angstroms Resolution within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl502 b:25.6 occ:0.50 O B:HOH812 2.9 23.2 1.0 NH1 B:ARG227 3.4 17.6 1.0 NZ B:LYS103 3.7 12.2 1.0 CG B:LYS103 4.0 13.0 1.0 CE B:LYS103 4.1 14.0 1.0 O B:PHE101 4.2 14.2 1.0 CD B:ARG227 4.4 16.6 1.0 OD1 B:ASP228 4.5 17.8 1.0 CZ B:ARG227 4.6 17.1 1.0 CD B:LYS103 4.7 13.1 1.0 OG1 B:THR231 4.8 14.6 1.0 N B:LYS103 4.8 12.6 1.0 O B:HOH805 5.0 18.5 1.0 NE B:ARG227 5.0 15.8 1.0

M.L.Mayer, A.Ghosal, N.P.Dolman, D.E.Jane. Crystal Structures of the Kainate Receptor GLUR5 Ligand Binding Core Dimer with Novel GLUR5-Selective Antagonists. J.Neurosci. V. 26 2852 2006.
ISSN: ISSN 0270-6474
PubMed: 16540562
DOI: 10.1523/JNEUROSCI.0123-06.2005