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Chlorine in PDB 2ghm: Mutated Map Kinase P38 (Mus Musculus) in Complex with Inhbitor Pg- 895449

Enzymatic activity of Mutated Map Kinase P38 (Mus Musculus) in Complex with Inhbitor Pg- 895449

All present enzymatic activity of Mutated Map Kinase P38 (Mus Musculus) in Complex with Inhbitor Pg- 895449:
2.7.1.37;

Protein crystallography data

The structure of Mutated Map Kinase P38 (Mus Musculus) in Complex with Inhbitor Pg- 895449, PDB code: 2ghm was solved by R.L.Walter, M.J.Mekel, A.G.Evdokimov, M.E.Pokross, J.A.Maier, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 50.00 / 2.35
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 65.169, 74.855, 77.879, 90.00, 90.00, 90.00
R / Rfree (%) 22.7 / 32.3

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Mutated Map Kinase P38 (Mus Musculus) in Complex with Inhbitor Pg- 895449 (pdb code 2ghm). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Mutated Map Kinase P38 (Mus Musculus) in Complex with Inhbitor Pg- 895449, PDB code: 2ghm:

Chlorine binding site 1 out of 1 in 2ghm

Go back to Chlorine Binding Sites List in 2ghm
Chlorine binding site 1 out of 1 in the Mutated Map Kinase P38 (Mus Musculus) in Complex with Inhbitor Pg- 895449


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Mutated Map Kinase P38 (Mus Musculus) in Complex with Inhbitor Pg- 895449 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl353

b:48.8
occ:1.00
CL16 A:LIC353 0.0 48.8 1.0
C12 A:LIC353 1.8 46.7 1.0
C15 A:LIC353 2.7 45.0 1.0
C9 A:LIC353 2.8 44.6 1.0
C7 A:LIC353 3.1 42.2 1.0
N5 A:LIC353 3.1 38.7 1.0
C53 A:LIC353 3.7 51.2 1.0
C43 A:LIC353 3.9 48.0 1.0
C11 A:LIC353 4.1 41.9 1.0
C13 A:LIC353 4.1 43.4 1.0
CB A:VAL38 4.2 46.7 1.0
C1 A:LIC353 4.2 36.9 1.0
C47 A:LIC353 4.3 49.1 1.0
CG2 A:VAL38 4.3 46.4 1.0
C45 A:LIC353 4.3 48.8 1.0
N42 A:LIC353 4.4 40.4 1.0
O A:VAL30 4.4 63.8 1.0
C14 A:LIC353 4.6 44.3 1.0
CB A:VAL30 4.6 63.1 1.0
C51 A:LIC353 4.6 50.5 1.0
C A:VAL30 4.7 63.7 1.0
CG1 A:VAL38 4.7 45.6 1.0
O4 A:LIC353 4.9 43.3 1.0
N A:GLY31 4.9 65.0 1.0
CA A:GLY31 5.0 66.2 1.0
N1 A:LIC353 5.0 39.1 1.0

Reference:

T.A.Brugel, J.A.Maier, M.P.Clark, M.Sabat, A.Golebiowski, R.G.Bookland, M.J.Laufersweiler, S.K.Laughlin, J.C.Vanrens, B.De, L.C.Hsieh, M.J.Mekel, M.J.Janusz. Development of N-2,4-Pyrimidine-N-Phenyl-N'-Phenyl Ureas As Inhibitors of Tumor Necrosis Factor Alpha (Tnf-Alpha) Synthesis. Part 1. Bioorg.Med.Chem.Lett. V. 16 3510 2006.
ISSN: ISSN 0960-894X
PubMed: 16632356
DOI: 10.1016/J.BMCL.2006.03.095
Page generated: Sat Dec 12 09:06:13 2020

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