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Chlorine in PDB 2gs6: Crystal Structure of the Active Egfr Kinase Domain in Complex with An Atp Analog-Peptide Conjugate

Enzymatic activity of Crystal Structure of the Active Egfr Kinase Domain in Complex with An Atp Analog-Peptide Conjugate

All present enzymatic activity of Crystal Structure of the Active Egfr Kinase Domain in Complex with An Atp Analog-Peptide Conjugate:
2.7.10.1;

Protein crystallography data

The structure of Crystal Structure of the Active Egfr Kinase Domain in Complex with An Atp Analog-Peptide Conjugate, PDB code: 2gs6 was solved by X.Zhang, J.Gureasko, K.Shen, P.A.Cole, J.Kuriyan, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 50.00 / 2.60
Space group I 2 3
Cell size a, b, c (Å), α, β, γ (°) 144.182, 144.182, 144.182, 90.00, 90.00, 90.00
R / Rfree (%) 20.6 / 25.7

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Crystal Structure of the Active Egfr Kinase Domain in Complex with An Atp Analog-Peptide Conjugate (pdb code 2gs6). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of the Active Egfr Kinase Domain in Complex with An Atp Analog-Peptide Conjugate, PDB code: 2gs6:

Chlorine binding site 1 out of 1 in 2gs6

Go back to Chlorine Binding Sites List in 2gs6
Chlorine binding site 1 out of 1 in the Crystal Structure of the Active Egfr Kinase Domain in Complex with An Atp Analog-Peptide Conjugate


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of the Active Egfr Kinase Domain in Complex with An Atp Analog-Peptide Conjugate within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl201

b:84.8
occ:1.00
O A:HOH37 3.2 37.1 1.0
NH1 A:ARG812 3.3 29.4 1.0
NH2 A:ARG812 3.6 27.7 1.0
CZ A:ARG812 3.9 29.5 1.0
O A:GLY849 4.1 57.0 1.0
CB A:ALA847 4.4 47.0 1.0
CD2 A:LEU834 4.7 26.0 1.0
CE A:LYS836 4.7 29.4 1.0
OH A:TYR845 5.0 36.5 1.0
NZ A:LYS836 5.0 32.6 1.0

Reference:

X.Zhang, J.Gureasko, K.Shen, P.A.Cole, J.Kuriyan. An Allosteric Mechanism For Activation of the Kinase Domain of Epidermal Growth Factor Receptor Cell(Cambridge,Mass.) V. 125 1137 2006.
ISSN: ISSN 0092-8674
PubMed: 16777603
DOI: 10.1016/J.CELL.2006.05.013
Page generated: Sat Jul 20 07:38:43 2024

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