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Chlorine in PDB 2hd6: Crystal Structure of the Human Carbonic Anhydrase II in Complex with A Hypoxia-Activatable Sulfonamide.
Enzymatic activity of Crystal Structure of the Human Carbonic Anhydrase II in Complex with A Hypoxia-Activatable Sulfonamide.
All present enzymatic activity of Crystal Structure of the Human Carbonic Anhydrase II in Complex with A Hypoxia-Activatable Sulfonamide.:
4.2.1.1;
4.2.1.1;
Protein crystallography data
The structure of Crystal Structure of the Human Carbonic Anhydrase II in Complex with A Hypoxia-Activatable Sulfonamide., PDB code: 2hd6
was solved by
G.De Simone,
R.M.Vitale,
A.Di Fiore,
C.Pedone,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 20.00 / 1.80 |
| Space group | P 1 21 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 42.070, 41.260, 71.660, 90.00, 104.28, 90.00 |
| R / Rfree (%) | 18.4 / 21.7 |
Other elements in 2hd6:
The structure of Crystal Structure of the Human Carbonic Anhydrase II in Complex with A Hypoxia-Activatable Sulfonamide. also contains other interesting chemical elements:
| Mercury | (Hg) | 1 atom |
| Zinc | (Zn) | 1 atom |
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Crystal Structure of the Human Carbonic Anhydrase II in Complex with A Hypoxia-Activatable Sulfonamide.
(pdb code 2hd6). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of the Human Carbonic Anhydrase II in Complex with A Hypoxia-Activatable Sulfonamide., PDB code: 2hd6:
In total only one binding site of Chlorine was determined in the Crystal Structure of the Human Carbonic Anhydrase II in Complex with A Hypoxia-Activatable Sulfonamide., PDB code: 2hd6:
Chlorine binding site 1 out of 1 in 2hd6
Go back to
Chlorine Binding Sites List in 2hd6
Chlorine binding site 1 out
of 1 in the Crystal Structure of the Human Carbonic Anhydrase II in Complex with A Hypoxia-Activatable Sulfonamide.
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 1 of Crystal Structure of the Human Carbonic Anhydrase II in Complex with A Hypoxia-Activatable Sulfonamide. within 5.0Å range:
|
Reference:
G.De Simone,
R.M.Vitale,
A.Di Fiore,
C.Pedone,
A.Scozzafava,
J.L.Montero,
J.Y.Winum,
C.T.Supuran.
Carbonic Anhydrase Inhibitors: Hypoxia-Activatable Sulfonamides Incorporating Disulfide Bonds That Target the Tumor-Associated Isoform IX. J.Med.Chem. V. 49 5544 2006.
ISSN: ISSN 0022-2623
PubMed: 16942027
DOI: 10.1021/JM060531J
Page generated: Sat Jul 20 07:47:40 2024
ISSN: ISSN 0022-2623
PubMed: 16942027
DOI: 10.1021/JM060531J
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