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Chlorine in PDB 2hl4: Crystal Structure Analysis of Human Carbonic Anhydrase II in Complex with A Benzenesulfonamide Derivative
Enzymatic activity of Crystal Structure Analysis of Human Carbonic Anhydrase II in Complex with A Benzenesulfonamide Derivative
All present enzymatic activity of Crystal Structure Analysis of Human Carbonic Anhydrase II in Complex with A Benzenesulfonamide Derivative:
4.2.1.1;
4.2.1.1;
Protein crystallography data
The structure of Crystal Structure Analysis of Human Carbonic Anhydrase II in Complex with A Benzenesulfonamide Derivative, PDB code: 2hl4
was solved by
A.Di Fiore,
C.T.Supuran,
J.-Y.Winum,
J.-L.Montero,
C.Pedone,
A.Scozzafava,
G.De Simone,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 20.00 / 1.55 |
| Space group | P 1 21 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 42.070, 41.120, 72.060, 90.00, 104.51, 90.00 |
| R / Rfree (%) | 17.6 / 19.8 |
Other elements in 2hl4:
The structure of Crystal Structure Analysis of Human Carbonic Anhydrase II in Complex with A Benzenesulfonamide Derivative also contains other interesting chemical elements:
| Mercury | (Hg) | 1 atom |
| Zinc | (Zn) | 1 atom |
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Crystal Structure Analysis of Human Carbonic Anhydrase II in Complex with A Benzenesulfonamide Derivative
(pdb code 2hl4). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure Analysis of Human Carbonic Anhydrase II in Complex with A Benzenesulfonamide Derivative, PDB code: 2hl4:
In total only one binding site of Chlorine was determined in the Crystal Structure Analysis of Human Carbonic Anhydrase II in Complex with A Benzenesulfonamide Derivative, PDB code: 2hl4:
Chlorine binding site 1 out of 1 in 2hl4
Go back to
Chlorine Binding Sites List in 2hl4
Chlorine binding site 1 out
of 1 in the Crystal Structure Analysis of Human Carbonic Anhydrase II in Complex with A Benzenesulfonamide Derivative
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 1 of Crystal Structure Analysis of Human Carbonic Anhydrase II in Complex with A Benzenesulfonamide Derivative within 5.0Å range:
|
Reference:
A.Di Fiore,
A.Scozzafava,
J.-Y.Winum,
J.-L.Montero,
C.Pedone,
C.T.Supuran,
G.De Simone.
Carbonic Anhydrase Inhibitors: Binding of An Antiglaucoma Glycosyl-Sulfanilamide Derivative to Human Isoform II and Its Consequences For the Drug Design of Enzyme Inhibitors Incorporating Sugar Moieties Bioorg.Med.Chem.Lett. V. 17 1726 2007.
ISSN: ISSN 0960-894X
PubMed: 17251017
DOI: 10.1016/J.BMCL.2006.12.099
Page generated: Sat Jul 20 07:52:02 2024
ISSN: ISSN 0960-894X
PubMed: 17251017
DOI: 10.1016/J.BMCL.2006.12.099
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