Chlorine in PDB 2hpm: Eubacterial and Eukaryotic Replicative Dna Polymerases Are Not Homologous: X-Ray Structure of Dna Polymerase III

Enzymatic activity of Eubacterial and Eukaryotic Replicative Dna Polymerases Are Not Homologous: X-Ray Structure of Dna Polymerase III

All present enzymatic activity of Eubacterial and Eukaryotic Replicative Dna Polymerases Are Not Homologous: X-Ray Structure of Dna Polymerase III:
2.7.7.7;

Protein crystallography data

The structure of Eubacterial and Eukaryotic Replicative Dna Polymerases Are Not Homologous: X-Ray Structure of Dna Polymerase III, PDB code: 2hpm was solved by S.Bailey, R.A.Wing, T.A.Steitz, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

*Resolution Low / High (Å)*	20.00 / 3.70
*Space group*	C 2 2 2₁
*Cell size a, b, c (Å), α, β, γ (°)*	174.442, 185.724, 125.836, 90.00, 90.00, 90.00
*R / R_free (%)*	24 / 31.1

Other elements in 2hpm:

The structure of Eubacterial and Eukaryotic Replicative Dna Polymerases Are Not Homologous: X-Ray Structure of Dna Polymerase III also contains other interesting chemical elements:

Magnesium	(Mg)	2 atoms
Zinc	(Zn)	2 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Eubacterial and Eukaryotic Replicative Dna Polymerases Are Not Homologous: X-Ray Structure of Dna Polymerase III (pdb code 2hpm). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Eubacterial and Eukaryotic Replicative Dna Polymerases Are Not Homologous: X-Ray Structure of Dna Polymerase III, PDB code: 2hpm:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in 2hpm

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Chlorine Binding Sites List in 2hpm

Chlorine binding site 1 out of 2 in the Eubacterial and Eukaryotic Replicative Dna Polymerases Are Not Homologous: X-Ray Structure of Dna Polymerase III

Mono view

Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Eubacterial and Eukaryotic Replicative Dna Polymerases Are Not Homologous: X-Ray Structure of Dna Polymerase III within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:Cl1225 b:89.7 occ:1.00	CL	A:CL1226	3.8	93.9	1.0
	NH1	A:ARG711	3.9	99.1	1.0
	O	A:GLY739	4.1	0.0	1.0
	CZ	A:PHE808	4.2	0.5	1.0
	NH2	A:ARG711	4.3	0.9	1.0
	CZ	A:ARG711	4.6	0.7	1.0
	CE1	A:PHE808	4.9	0.8	1.0

Chlorine binding site 2 out of 2 in 2hpm

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Chlorine Binding Sites List in 2hpm

Chlorine binding site 2 out of 2 in the Eubacterial and Eukaryotic Replicative Dna Polymerases Are Not Homologous: X-Ray Structure of Dna Polymerase III

Mono view

Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Eubacterial and Eukaryotic Replicative Dna Polymerases Are Not Homologous: X-Ray Structure of Dna Polymerase III within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:Cl1226 b:93.9 occ:1.00	CL	A:CL1225	3.8	89.7	1.0
	SD	A:MET804	3.8	0.5	1.0
	O	A:GLY739	4.0	0.0	1.0
	CE1	A:PHE723	4.2	0.1	1.0
	CD2	A:TYR720	4.6	0.0	1.0
	CE2	A:TYR720	4.6	0.7	1.0
	CD1	A:PHE723	5.0	0.4	1.0

Reference:

S.Bailey, R.A.Wing, T.A.Steitz. The Structure of T. Aquaticus Dna Polymerase III Is Distinct From Eukaryotic Replicative Dna Polymerases. Cell(Cambridge,Mass.) V. 126 893 2006.
ISSN: ISSN 0092-8674
PubMed: 16959569
DOI: 10.1016/J.CELL.2006.07.027

Page generated: Sat Jul 20 07:53:25 2024

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