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Chlorine in PDB 2ieh: Crystal Structure of Human Kinesin EG5 in Complex with (R)- MON97, A New Monastrol-Based Inhibitor That Binds As (R)- Enantiomer
Enzymatic activity of Crystal Structure of Human Kinesin EG5 in Complex with (R)- MON97, A New Monastrol-Based Inhibitor That Binds As (R)- Enantiomer
All present enzymatic activity of Crystal Structure of Human Kinesin EG5 in Complex with (R)- MON97, A New Monastrol-Based Inhibitor That Binds As (R)- Enantiomer:
3.6.4.4;
3.6.4.4;
Protein crystallography data
The structure of Crystal Structure of Human Kinesin EG5 in Complex with (R)- MON97, A New Monastrol-Based Inhibitor That Binds As (R)- Enantiomer, PDB code: 2ieh
was solved by
I.Garcia-Saez,
F.Kozielski,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 25.00 / 2.70 |
| Space group | P 21 21 21 |
| Cell size a, b, c (Å), α, β, γ (°) | 69.370, 79.900, 159.860, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 23.4 / 28.1 |
Other elements in 2ieh:
The structure of Crystal Structure of Human Kinesin EG5 in Complex with (R)- MON97, A New Monastrol-Based Inhibitor That Binds As (R)- Enantiomer also contains other interesting chemical elements:
| Magnesium | (Mg) | 2 atoms |
| Potassium | (K) | 1 atom |
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Crystal Structure of Human Kinesin EG5 in Complex with (R)- MON97, A New Monastrol-Based Inhibitor That Binds As (R)- Enantiomer
(pdb code 2ieh). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of Human Kinesin EG5 in Complex with (R)- MON97, A New Monastrol-Based Inhibitor That Binds As (R)- Enantiomer, PDB code: 2ieh:
In total only one binding site of Chlorine was determined in the Crystal Structure of Human Kinesin EG5 in Complex with (R)- MON97, A New Monastrol-Based Inhibitor That Binds As (R)- Enantiomer, PDB code: 2ieh:
Chlorine binding site 1 out of 1 in 2ieh
Go back to
Chlorine Binding Sites List in 2ieh
Chlorine binding site 1 out
of 1 in the Crystal Structure of Human Kinesin EG5 in Complex with (R)- MON97, A New Monastrol-Based Inhibitor That Binds As (R)- Enantiomer
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 1 of Crystal Structure of Human Kinesin EG5 in Complex with (R)- MON97, A New Monastrol-Based Inhibitor That Binds As (R)- Enantiomer within 5.0Å range:
|
Reference:
I.Garcia-Saez,
S.Debonis,
R.Lopez,
F.Trucco,
B.Rousseau,
P.Thuery,
F.Kozielski.
Structure of Human EG5 in Complex with A New Monastrol-Based Inhibitor Bound in the R Configuration. J.Biol.Chem. V. 282 9740 2007.
ISSN: ISSN 0021-9258
PubMed: 17251189
DOI: 10.1074/JBC.M608883200
Page generated: Sat Jul 20 08:11:26 2024
ISSN: ISSN 0021-9258
PubMed: 17251189
DOI: 10.1074/JBC.M608883200
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