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Chlorine in PDB 2ilt: Human 11-Beta-Hydroxysteroid Dehydrogenase (HSD1) with Nadp and Adamantane Sulfone Inhibitor
Enzymatic activity of Human 11-Beta-Hydroxysteroid Dehydrogenase (HSD1) with Nadp and Adamantane Sulfone Inhibitor
All present enzymatic activity of Human 11-Beta-Hydroxysteroid Dehydrogenase (HSD1) with Nadp and Adamantane Sulfone Inhibitor:
1.1.1.146;
1.1.1.146;
Protein crystallography data
The structure of Human 11-Beta-Hydroxysteroid Dehydrogenase (HSD1) with Nadp and Adamantane Sulfone Inhibitor, PDB code: 2ilt
was solved by
K.L.Longenecker,
B.Sorensen,
R.Judge,
W.Qin,
J.T.Link,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 87.71 / 2.30 |
| Space group | I 2 3 |
| Cell size a, b, c (Å), α, β, γ (°) | 123.871, 123.871, 123.871, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 20.9 / 27.5 |
Other elements in 2ilt:
The structure of Human 11-Beta-Hydroxysteroid Dehydrogenase (HSD1) with Nadp and Adamantane Sulfone Inhibitor also contains other interesting chemical elements:
| Fluorine | (F) | 1 atom |
| Nickel | (Ni) | 2 atoms |
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Human 11-Beta-Hydroxysteroid Dehydrogenase (HSD1) with Nadp and Adamantane Sulfone Inhibitor
(pdb code 2ilt). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Human 11-Beta-Hydroxysteroid Dehydrogenase (HSD1) with Nadp and Adamantane Sulfone Inhibitor, PDB code: 2ilt:
In total only one binding site of Chlorine was determined in the Human 11-Beta-Hydroxysteroid Dehydrogenase (HSD1) with Nadp and Adamantane Sulfone Inhibitor, PDB code: 2ilt:
Chlorine binding site 1 out of 1 in 2ilt
Go back to
Chlorine Binding Sites List in 2ilt
Chlorine binding site 1 out
of 1 in the Human 11-Beta-Hydroxysteroid Dehydrogenase (HSD1) with Nadp and Adamantane Sulfone Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 1 of Human 11-Beta-Hydroxysteroid Dehydrogenase (HSD1) with Nadp and Adamantane Sulfone Inhibitor within 5.0Å range:
|
Reference:
B.Sorensen,
M.Winn,
J.Rohde,
Q.Shuai,
J.Wang,
S.Fung,
K.Monzon,
W.Chiou,
D.Stolarik,
H.Imade,
L.Pan,
X.Deng,
L.Chovan,
K.Longenecker,
R.Judge,
W.Qin,
M.Brune,
H.Camp,
E.U.Frevert,
P.Jacobson,
J.T.Link.
Adamantane Sulfone and Sulfonamide 11-Beta-HSD1 Inhibitors. Bioorg.Med.Chem.Lett. V. 17 527 2007.
ISSN: ISSN 0960-894X
PubMed: 17070044
DOI: 10.1016/J.BMCL.2006.10.008
Page generated: Sat Jul 20 08:19:36 2024
ISSN: ISSN 0960-894X
PubMed: 17070044
DOI: 10.1016/J.BMCL.2006.10.008
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