Chlorine in PDB 2iux: Human Tace Mutant G1234

All present enzymatic activity of Human Tace Mutant G1234:
3.4.15.1;

The structure of Human Tace Mutant G1234, PDB code: 2iux was solved by J.M.Watermeyer, B.T.Swell, R.Natesh, H.R.Corradi, K.R.Acharya, E.D.Sturrock, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	50.0 / 2.8
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	56.436, 85.149, 133.424, 90.00, 90.00, 90.00
R / Rfree (%)	20.06 / 23.69

The structure of Human Tace Mutant G1234 also contains other interesting chemical elements:

Zinc

(Zn)

1 atom

The binding sites of Chlorine atom in the Human Tace Mutant G1234 (pdb code 2iux). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Human Tace Mutant G1234, PDB code: 2iux:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Human Tace Mutant G1234


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Human Tace Mutant G1234 within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1622 b:15.9 occ:1.00 NE A:ARG186 3.1 13.1 1.0 NH1 A:ARG186 3.3 13.4 1.0 NH1 A:ARG489 3.3 12.7 1.0 CZ2 A:TRP486 3.3 9.8 1.0 NE1 A:TRP485 3.4 11.3 1.0 CZ A:ARG186 3.6 13.0 1.0 CB A:ASP507 3.8 11.4 1.0 CH2 A:TRP486 3.8 11.7 1.0 NE A:ARG489 3.8 10.7 1.0 CZ A:ARG489 3.8 11.5 1.0 CE2 A:TRP486 4.2 9.2 1.0 CD A:ARG186 4.2 13.2 1.0 CZ2 A:TRP182 4.2 20.2 1.0 CE2 A:TRP485 4.3 11.2 1.0 CD1 A:TRP485 4.3 13.1 1.0 CZ2 A:TRP485 4.5 12.0 1.0 O A:ASP507 4.5 11.3 1.0 CG A:ASP507 4.5 12.9 1.0 NE1 A:TRP486 4.6 8.9 1.0 C A:ASP507 4.8 10.6 1.0 CA A:ASP507 4.8 10.4 1.0 NE1 A:TRP182 4.8 21.6 1.0 CE2 A:TRP182 4.9 21.0 1.0 NH2 A:ARG489 4.9 14.7 1.0 CZ3 A:TRP486 4.9 11.0 1.0 NH2 A:ARG186 4.9 12.2 1.0 CD A:ARG489 5.0 10.3 1.0

Chlorine binding site 2 out of 2 in the Human Tace Mutant G1234


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Human Tace Mutant G1234 within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1623 b:14.3 occ:1.00 OH A:TYR224 3.0 13.4 1.0 O A:HOH2014 3.1 15.3 1.0 NE A:ARG522 3.2 15.2 1.0 CB A:ARG522 3.4 7.0 1.0 CB A:PRO407 3.5 10.3 1.0 CE1 A:TYR224 3.6 10.9 1.0 CB A:PRO519 3.6 8.3 1.0 NH2 A:ARG522 3.6 15.8 1.0 N A:ARG522 3.6 8.4 1.0 CZ A:TYR224 3.7 12.5 1.0 CG A:PRO407 3.8 11.1 1.0 CE A:MET223 3.8 13.6 1.0 CZ A:ARG522 3.8 16.1 1.0 CG2 A:ILE521 3.8 8.4 1.0 CA A:ARG522 3.9 9.4 1.0 CG A:ARG522 4.0 7.9 1.0 CD A:ARG522 4.2 11.9 1.0 C A:ILE521 4.5 9.8 1.0 CG A:PRO519 4.6 7.8 1.0 C A:PRO519 4.7 9.3 1.0 CA A:PRO519 4.7 9.0 1.0 O A:PRO519 4.8 10.1 1.0 N A:ILE521 4.8 10.6 1.0 CD1 A:TYR224 4.8 8.5 1.0 SD A:MET223 4.8 13.0 1.0 CD A:PRO407 4.8 10.8 1.0 CA A:PRO407 5.0 10.1 1.0 CA A:ILE521 5.0 8.8 1.0 CE2 A:TYR224 5.0 11.4 1.0

J.M.Watermeyer, B.T.Sewell, S.L.Schwager, R.Natesh, H.R.Corradi, K.R.Acharya, E.D.Sturrock. Structure of Testis Ace Glycosylation Mutants and Evidence For Conserved Domain Movement. Biochemistry V. 45 12654 2006.
ISSN: ISSN 0006-2960
PubMed: 17042482
DOI: 10.1021/BI061146Z