Chlorine in PDB 2iw5: Structural Basis For Corest-Dependent Demethylation of Nucleosomes By the Human LSD1 Histone Demethylase

The structure of Structural Basis For Corest-Dependent Demethylation of Nucleosomes By the Human LSD1 Histone Demethylase, PDB code: 2iw5 was solved by M.Yang, C.B.Gocke, X.Luo, D.Borek, D.R.Tomchick, M.Machius, Z.Otwinowski, H.Yu, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	20.00 / 2.57
Space group	I 2 2 2
Cell size a, b, c (Å), α, β, γ (°)	120.354, 178.222, 234.932, 90.00, 90.00, 90.00
R / Rfree (%)	20.3 / 21.2

The binding sites of Chlorine atom in the Structural Basis For Corest-Dependent Demethylation of Nucleosomes By the Human LSD1 Histone Demethylase (pdb code 2iw5). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 3 binding sites of Chlorine where determined in the Structural Basis For Corest-Dependent Demethylation of Nucleosomes By the Human LSD1 Histone Demethylase, PDB code: 2iw5:
Jump to Chlorine binding site number: 1; 2; 3;

Chlorine binding site 1 out of 3 in the Structural Basis For Corest-Dependent Demethylation of Nucleosomes By the Human LSD1 Histone Demethylase


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Structural Basis For Corest-Dependent Demethylation of Nucleosomes By the Human LSD1 Histone Demethylase within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1838 b:53.8 occ:0.50 CL A:CL1843 2.2 59.0 0.5 OD2 A:ASP754 3.2 72.7 1.0 CH2 A:TRP751 3.9 67.8 1.0 CZ3 A:TRP751 4.0 67.6 1.0 NH1 A:ARG310 4.2 67.1 1.0 CZ2 A:TRP751 4.2 67.8 1.0 CG A:ASP754 4.3 72.1 1.0 CE3 A:TRP751 4.4 66.9 1.0 CE2 A:TRP751 4.6 67.7 1.0 CD2 A:TRP751 4.7 67.6 1.0 NH2 A:ARG312 4.8 66.3 1.0 CB A:ASP754 4.8 70.4 1.0 O A:HOH2011 4.9 54.1 1.0 CZ A:ARG310 5.0 68.1 1.0

Chlorine binding site 2 out of 3 in the Structural Basis For Corest-Dependent Demethylation of Nucleosomes By the Human LSD1 Histone Demethylase


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Structural Basis For Corest-Dependent Demethylation of Nucleosomes By the Human LSD1 Histone Demethylase within 5.0Å range:

Chlorine binding site 3 out of 3 in the Structural Basis For Corest-Dependent Demethylation of Nucleosomes By the Human LSD1 Histone Demethylase


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Structural Basis For Corest-Dependent Demethylation of Nucleosomes By the Human LSD1 Histone Demethylase within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1843 b:59.0 occ:0.50 CL A:CL1838 2.2 53.8 0.5 N A:ARG750 3.6 69.2 1.0 CB A:SER749 3.9 68.7 1.0 CA A:SER749 4.0 69.0 1.0 C A:ARG750 4.2 69.7 1.0 CE2 A:TRP751 4.3 67.7 1.0 C A:SER749 4.3 69.2 1.0 O A:ARG750 4.3 70.3 1.0 OD2 A:ASP754 4.3 72.7 1.0 CD2 A:TRP751 4.4 67.6 1.0 N A:TRP751 4.5 69.5 1.0 CZ2 A:TRP751 4.5 67.8 1.0 CA A:ARG750 4.5 69.5 1.0 NE1 A:TRP751 4.6 68.0 1.0 CE3 A:TRP751 4.6 66.9 1.0 CH2 A:TRP751 4.8 67.8 1.0 CG A:TRP751 4.8 68.7 1.0 CZ3 A:TRP751 4.8 67.6 1.0 CA A:TRP751 4.9 69.1 1.0 CD1 A:TRP751 4.9 68.2 1.0 CB A:ASP754 5.0 70.4 1.0

M.Yang, C.B.Gocke, X.Luo, D.Borek, D.R.Tomchick, M.Machius, Z.Otwinowski, H.Yu. Structural Basis For Corest-Dependent Demethylation of Nucleosomes By the Human LSD1 Histone Demethylase Mol.Cell V. 23 377 2006.
ISSN: ISSN 1097-2765
PubMed: 16885027
DOI: 10.1016/J.MOLCEL.2006.07.012