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Chlorine in PDB 2j7t: Crystal Structure of Human Serine Threonine Kinase-10 Bound to SU11274

Enzymatic activity of Crystal Structure of Human Serine Threonine Kinase-10 Bound to SU11274

All present enzymatic activity of Crystal Structure of Human Serine Threonine Kinase-10 Bound to SU11274:
2.7.11.1;

Protein crystallography data

The structure of Crystal Structure of Human Serine Threonine Kinase-10 Bound to SU11274, PDB code: 2j7t was solved by A.C.W.Pike, P.Rellos, O.Fedorov, S.Das, J.Debreczeni, F.Sobott, S.Watt, P.Savitsky, J.Eswaran, A.P.Turnbull, E.Papagrigoriou, E.Ugochukwa, F.Gorrec, C.C.Umeano, F.Von Delft, C.H.Arrowsmith, A.Edwards, J.Weigelt, M.Sundstrom, S.Knapp, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 55.00 / 2.00
Space group I 2 2 2
Cell size a, b, c (Å), α, β, γ (°) 49.192, 112.960, 133.817, 90.00, 90.00, 90.00
R / Rfree (%) 20.4 / 23.5

Other elements in 2j7t:

The structure of Crystal Structure of Human Serine Threonine Kinase-10 Bound to SU11274 also contains other interesting chemical elements:

Calcium (Ca) 7 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Crystal Structure of Human Serine Threonine Kinase-10 Bound to SU11274 (pdb code 2j7t). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of Human Serine Threonine Kinase-10 Bound to SU11274, PDB code: 2j7t:

Chlorine binding site 1 out of 1 in 2j7t

Go back to Chlorine Binding Sites List in 2j7t
Chlorine binding site 1 out of 1 in the Crystal Structure of Human Serine Threonine Kinase-10 Bound to SU11274


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Human Serine Threonine Kinase-10 Bound to SU11274 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl1324

b:44.1
occ:1.00
 CL1 A:2741324 0.0 44.1 1.0
C2 A:2741324 1.7 42.7 1.0
C1 A:2741324 2.7 42.1 1.0
C4 A:2741324 2.7 42.3 1.0
OE1 A:GLU81 3.3 41.9 1.0
CD A:GLU81 3.7 39.8 1.0
CD1 A:ILE108 3.8 37.5 1.0
CG2 A:ILE108 3.8 37.1 1.0
OE2 A:GLU81 4.0 41.1 1.0
C3 A:2741324 4.0 42.4 1.0
C5 A:2741324 4.0 42.7 1.0
CB A:ILE108 4.2 37.4 1.0
CD2 A:TYR78 4.2 41.9 1.0
CE2 A:TYR78 4.2 41.9 1.0
CD1 A:ILE110 4.3 38.0 1.0
O A:HOH2061 4.4 43.7 1.0
CD A:LYS65 4.4 40.9 1.0
C6 A:2741324 4.5 42.7 1.0
CG A:GLU81 4.5 39.6 1.0
CG1 A:ILE108 4.6 37.2 1.0
CD1 A:LEU85 4.6 43.4 1.0
O A:HOH2007 4.6 39.6 1.0
CB A:LYS65 4.8 39.1 1.0
CG A:LYS65 4.9 40.4 1.0

Reference:

A.C.W.Pike, P.Rellos, F.H.Niesen, A.Turnbull, A.W.Oliver, S.A.Parker, B.E.Turk, L.H.Pearl, S.Knapp. Activation Segment Dimerization: A Mechanism For Kinase Autophosphorylation of Non-Consensus Sites. Embo J. V. 27 704 2008.
ISSN: ISSN 0261-4189
PubMed: 18239682
DOI: 10.1038/EMBOJ.2008.8
Page generated: Sat Jul 20 08:44:09 2024

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