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Chlorine in PDB 2jbj: Membrane-Bound Glutamate Carboxypeptidase II (Gcpii) in Complex with 2-Pmpa (2-Phosphonomethyl-Pentanedioic Acid)

Enzymatic activity of Membrane-Bound Glutamate Carboxypeptidase II (Gcpii) in Complex with 2-Pmpa (2-Phosphonomethyl-Pentanedioic Acid)

All present enzymatic activity of Membrane-Bound Glutamate Carboxypeptidase II (Gcpii) in Complex with 2-Pmpa (2-Phosphonomethyl-Pentanedioic Acid):
3.4.17.21;

Protein crystallography data

The structure of Membrane-Bound Glutamate Carboxypeptidase II (Gcpii) in Complex with 2-Pmpa (2-Phosphonomethyl-Pentanedioic Acid), PDB code: 2jbj was solved by J.R.Mesters, K.Henning, R.Hilgenfeld, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 101.02 / 2.19
Space group I 2 2 2
Cell size a, b, c (Å), α, β, γ (°) 100.755, 130.982, 159.611, 90.00, 90.00, 90.00
R / Rfree (%) 19.2 / 23.8

Other elements in 2jbj:

The structure of Membrane-Bound Glutamate Carboxypeptidase II (Gcpii) in Complex with 2-Pmpa (2-Phosphonomethyl-Pentanedioic Acid) also contains other interesting chemical elements:

Calcium (Ca) 1 atom
Zinc (Zn) 2 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Membrane-Bound Glutamate Carboxypeptidase II (Gcpii) in Complex with 2-Pmpa (2-Phosphonomethyl-Pentanedioic Acid) (pdb code 2jbj). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Membrane-Bound Glutamate Carboxypeptidase II (Gcpii) in Complex with 2-Pmpa (2-Phosphonomethyl-Pentanedioic Acid), PDB code: 2jbj:

Chlorine binding site 1 out of 1 in 2jbj

Go back to Chlorine Binding Sites List in 2jbj
Chlorine binding site 1 out of 1 in the Membrane-Bound Glutamate Carboxypeptidase II (Gcpii) in Complex with 2-Pmpa (2-Phosphonomethyl-Pentanedioic Acid)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Membrane-Bound Glutamate Carboxypeptidase II (Gcpii) in Complex with 2-Pmpa (2-Phosphonomethyl-Pentanedioic Acid) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl1754

b:37.9
occ:1.00
 O A:HOH2204 3.1 43.1 1.0
ND2 A:ASN451 3.3 32.3 1.0
NE A:ARG534 3.3 39.0 1.0
NH2 A:ARG534 3.3 34.4 1.0
O A:HOH2206 3.4 36.8 1.0
N A:ASP453 3.5 31.7 1.0
CB A:ASP453 3.7 32.1 1.0
CB A:ARG534 3.7 31.9 1.0
CZ A:ARG534 3.8 41.0 1.0
NH2 A:ARG580 4.0 25.6 1.0
CB A:ASN451 4.0 28.3 1.0
CA A:ASP453 4.1 33.5 1.0
CG A:ASN451 4.1 31.3 1.0
N A:ALA452 4.2 30.1 1.0
C A:ASN451 4.3 29.7 1.0
C A:ASP453 4.3 35.2 1.0
O A:ASP453 4.4 36.3 1.0
O A:ASN451 4.4 29.3 1.0
CD A:ARG534 4.4 40.1 1.0
CD A:ARG536 4.5 55.2 1.0
C A:ALA452 4.5 31.9 1.0
CA A:ALA452 4.5 31.0 1.0
CG A:ARG534 4.5 31.4 1.0
O A:SER454 4.7 39.4 1.0
CZ A:ARG580 4.8 30.0 1.0
CA A:ARG534 4.8 33.3 1.0
CA A:ASN451 4.8 28.9 1.0
O A:ALA535 4.9 34.4 1.0
NE A:ARG536 4.9 61.6 1.0
N A:ALA535 5.0 34.5 1.0
OD1 A:ASN519 5.0 33.8 1.0

Reference:

J.R.Mesters, K.Henning, R.Hilgenfeld. Human Glutamate Carboxypeptidase II Inhibition: Structures of Gcpii in Complex with Two Potent Inhibitors, Quisqualate and 2-Pmpa. Acta Crystallogr.,Sect.D V. 63 508 2007.
ISSN: ISSN 0907-4449
PubMed: 17372356
DOI: 10.1107/S090744490700902X
Page generated: Sat Jul 20 08:48:41 2024

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