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Chlorine in PDB 2jjd: Protein Tyrosine Phosphatase, Receptor Type, E Isoform

Enzymatic activity of Protein Tyrosine Phosphatase, Receptor Type, E Isoform

All present enzymatic activity of Protein Tyrosine Phosphatase, Receptor Type, E Isoform:
3.1.3.48;

Protein crystallography data

The structure of Protein Tyrosine Phosphatase, Receptor Type, E Isoform, PDB code: 2jjd was solved by J.M.Elkins, E.Ugochukwu, I.Alfano, A.J.Barr, G.Bunkoczi, O.N.F.King, P.Filippakopoulos, P.Savitsky, E.Salah, A.Pike, C.Johansson, S.Das, N.A.Burgess-Brown, O.Gileadi, F.Von Delft, C.H.Arrowsmith, C.Bountra, A.M.Edwards, S.Knapp, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 218.22 / 3.20
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 126.020, 123.616, 219.116, 90.00, 91.13, 90.00
R / Rfree (%) 22.1 / 25.6

Chlorine Binding Sites:

Pages:

>>> Page 1 <<< Page 2, Binding sites: 11 - 12;

Binding sites:

The binding sites of Chlorine atom in the Protein Tyrosine Phosphatase, Receptor Type, E Isoform (pdb code 2jjd). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 12 binding sites of Chlorine where determined in the Protein Tyrosine Phosphatase, Receptor Type, E Isoform, PDB code: 2jjd:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9; 10;

Chlorine binding site 1 out of 12 in 2jjd

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Chlorine binding site 1 out of 12 in the Protein Tyrosine Phosphatase, Receptor Type, E Isoform


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Protein Tyrosine Phosphatase, Receptor Type, E Isoform within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl1692

b:65.8
occ:1.00
 N A:LEU236 3.4 63.9 1.0
CB A:LEU236 3.6 64.0 1.0
CA A:LEU236 4.0 63.9 1.0
N A:LYS237 4.0 64.7 1.0
CG A:LEU236 4.0 63.5 1.0
CB A:ASN235 4.1 63.3 1.0
CD1 A:LEU236 4.2 63.1 1.0
C A:ASN235 4.4 63.5 1.0
CA A:ASN235 4.5 63.2 1.0
C A:LEU236 4.6 64.2 1.0
OD1 A:ASN235 4.7 64.5 1.0
O A:LYS237 4.7 65.5 1.0
CG A:ASN235 4.8 63.8 1.0

Chlorine binding site 2 out of 12 in 2jjd

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Chlorine binding site 2 out of 12 in the Protein Tyrosine Phosphatase, Receptor Type, E Isoform


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Protein Tyrosine Phosphatase, Receptor Type, E Isoform within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl1693

b:51.0
occ:1.00
 NE2 A:GLN383 3.9 63.6 1.0
O A:VAL339 4.2 64.3 1.0
N A:ARG341 4.3 63.2 1.0
NE A:ARG341 4.3 63.2 1.0
CD A:ARG341 4.3 63.0 1.0
CA A:GLY340 4.4 63.4 1.0
CG A:ARG341 4.6 62.8 1.0
C A:GLY340 4.8 63.4 1.0
CB A:GLN379 4.8 63.6 1.0
CG A:GLN379 5.0 64.7 1.0

Chlorine binding site 3 out of 12 in 2jjd

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Chlorine binding site 3 out of 12 in the Protein Tyrosine Phosphatase, Receptor Type, E Isoform


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Protein Tyrosine Phosphatase, Receptor Type, E Isoform within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl1692

b:41.7
occ:1.00
 NH2 B:ARG341 3.6 63.8 1.0
NE B:ARG341 3.6 63.2 1.0
O B:ASP303 3.9 64.2 1.0
CZ B:ARG341 4.0 63.2 1.0
CD2 B:PHE304 4.4 64.3 1.0
CD B:ARG341 4.7 63.0 1.0
CA B:PHE304 4.7 64.4 1.0
CE2 B:PHE304 4.7 64.4 1.0
NE2 B:GLN383 4.9 64.6 1.0
C B:ASP303 5.0 64.1 1.0

Chlorine binding site 4 out of 12 in 2jjd

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Chlorine binding site 4 out of 12 in the Protein Tyrosine Phosphatase, Receptor Type, E Isoform


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Protein Tyrosine Phosphatase, Receptor Type, E Isoform within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl1693

b:74.1
occ:1.00
 N B:LEU236 3.4 63.9 1.0
CB B:LEU236 3.8 63.9 1.0
CB B:ASN235 3.9 63.3 1.0
N B:LYS237 4.1 64.8 1.0
CA B:LEU236 4.1 63.9 1.0
O B:LYS237 4.2 65.6 1.0
CG B:LEU236 4.3 63.7 1.0
C B:ASN235 4.3 63.5 1.0
OD1 B:ASN235 4.4 64.7 1.0
CA B:ASN235 4.4 63.2 1.0
CG B:ASN235 4.5 63.8 1.0
C B:LEU236 4.6 64.3 1.0
CD1 B:LEU236 4.6 63.5 1.0
C B:LYS237 5.0 65.5 1.0

Chlorine binding site 5 out of 12 in 2jjd

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Chlorine binding site 5 out of 12 in the Protein Tyrosine Phosphatase, Receptor Type, E Isoform


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 5 of Protein Tyrosine Phosphatase, Receptor Type, E Isoform within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl1694

b:83.0
occ:1.00
 N B:PRO330 4.0 62.7 1.0
O B:ASN202 4.0 62.9 1.0
C B:GLY329 4.0 63.0 1.0
O B:ALA328 4.0 63.4 1.0
CD B:PRO330 4.2 62.6 1.0
CA B:GLY329 4.2 63.0 1.0
O B:GLY329 4.5 63.3 1.0
CA B:PRO330 4.5 62.7 1.0
CB B:PRO330 4.8 62.6 1.0
OE2 B:GLU200 4.9 66.8 1.0
C B:ASN202 5.0 62.8 1.0
C B:ALA328 5.0 63.2 1.0

Chlorine binding site 6 out of 12 in 2jjd

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Chlorine binding site 6 out of 12 in the Protein Tyrosine Phosphatase, Receptor Type, E Isoform


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 6 of Protein Tyrosine Phosphatase, Receptor Type, E Isoform within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Cl1692

b:43.6
occ:1.00
 NH2 A:ARG531 3.8 64.1 1.0
NE C:ARG341 3.8 63.1 1.0
NH2 C:ARG341 4.0 63.9 1.0
NH1 A:ARG531 4.0 63.5 1.0
O C:ASP303 4.3 64.2 1.0
CZ C:ARG341 4.3 63.1 1.0
CZ A:ARG531 4.4 63.5 1.0
NE2 C:GLN383 4.4 64.6 1.0
CD2 C:PHE304 4.5 64.6 1.0
CD C:ARG341 4.8 63.0 1.0
CA C:PHE304 5.0 64.7 1.0

Chlorine binding site 7 out of 12 in 2jjd

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Chlorine binding site 7 out of 12 in the Protein Tyrosine Phosphatase, Receptor Type, E Isoform


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 7 of Protein Tyrosine Phosphatase, Receptor Type, E Isoform within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Cl1692

b:78.6
occ:1.00
 N D:LEU236 3.4 63.8 1.0
CB D:LEU236 3.8 63.8 1.0
CB D:ASN235 3.8 63.3 1.0
N D:LYS237 4.1 64.6 1.0
CA D:LEU236 4.1 63.9 1.0
C D:ASN235 4.3 63.5 1.0
CG D:LEU236 4.3 63.5 1.0
CD1 D:LEU236 4.3 63.3 1.0
OD1 D:ASN235 4.3 64.5 1.0
CA D:ASN235 4.4 63.2 1.0
CG D:ASN235 4.4 63.8 1.0
O D:LYS237 4.5 65.4 1.0
C D:LEU236 4.7 64.2 1.0

Chlorine binding site 8 out of 12 in 2jjd

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Chlorine binding site 8 out of 12 in the Protein Tyrosine Phosphatase, Receptor Type, E Isoform


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 8 of Protein Tyrosine Phosphatase, Receptor Type, E Isoform within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Cl1693

b:40.2
occ:1.00
 NE2 D:GLN383 3.6 64.2 1.0
O D:VAL339 4.0 64.2 1.0
CA D:GLY340 4.1 63.3 1.0
N D:ARG341 4.2 63.1 1.0
CG D:GLN379 4.4 65.2 1.0
CB D:GLN379 4.5 64.0 1.0
CD D:ARG341 4.5 63.0 1.0
C D:GLY340 4.6 63.4 1.0
NE D:ARG341 4.6 63.2 1.0
CD D:GLN383 4.7 63.5 1.0
CG D:ARG341 4.7 62.8 1.0
OE1 D:GLN383 4.9 64.5 1.0
C D:VAL339 5.0 63.6 1.0

Chlorine binding site 9 out of 12 in 2jjd

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Chlorine binding site 9 out of 12 in the Protein Tyrosine Phosphatase, Receptor Type, E Isoform


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 9 of Protein Tyrosine Phosphatase, Receptor Type, E Isoform within 5.0Å range:
probe atom residue distance (Å) B Occ
E:Cl1692

b:66.5
occ:1.00
 N E:LEU236 3.5 63.8 1.0
CB E:ASN235 3.8 63.3 1.0
N E:LYS237 4.0 65.0 1.0
CB E:LEU236 4.0 64.2 1.0
O E:LYS237 4.1 65.8 1.0
CA E:LEU236 4.2 64.2 1.0
C E:ASN235 4.4 63.5 1.0
OD1 E:ASN235 4.4 64.6 1.0
CA E:ASN235 4.4 63.2 1.0
CG E:ASN235 4.4 63.7 1.0
CG E:LEU236 4.6 64.0 1.0
C E:LEU236 4.7 64.6 1.0
CD1 E:LEU236 5.0 63.7 1.0
CA E:LYS237 5.0 65.3 1.0
C E:LYS237 5.0 65.6 1.0

Chlorine binding site 10 out of 12 in 2jjd

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Chlorine binding site 10 out of 12 in the Protein Tyrosine Phosphatase, Receptor Type, E Isoform


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 10 of Protein Tyrosine Phosphatase, Receptor Type, E Isoform within 5.0Å range:
probe atom residue distance (Å) B Occ
E:Cl1693

b:40.1
occ:1.00
 NE2 E:GLN383 4.0 64.3 1.0
O E:VAL339 4.1 64.3 1.0
N E:ARG341 4.1 63.2 1.0
CD E:ARG341 4.2 63.0 1.0
CA E:GLY340 4.3 63.3 1.0
NE E:ARG341 4.3 63.3 1.0
CG E:ARG341 4.5 62.8 1.0
C E:GLY340 4.7 63.4 1.0
CG E:GLN379 4.8 65.2 1.0
CB E:GLN379 4.8 63.9 1.0

Reference:

A.J.Barr, E.Ugochukwu, W.H.Lee, O.N.F.King, P.Filippakopoulos, I.Alfano, P.Savitsky, N.A.Burgess-Brown, S.Muller, S.Knapp. Large-Scale Structural Analysis of the Classical Human Protein Tyrosine Phosphatome. Cell(Cambridge,Mass.) V. 136 352 2009.
ISSN: ISSN 0092-8674
PubMed: 19167335
DOI: 10.1016/J.CELL.2008.11.038
Page generated: Sat Dec 12 09:10:56 2020

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