Chlorine in PDB 2kuh: Halothane Binds to Druggable Sites in Calcium-Calmodulin: Solution Structure of Halothane-Cam C-Terminal Domain

The structure of Halothane Binds to Druggable Sites in Calcium-Calmodulin: Solution Structure of Halothane-Cam C-Terminal Domain also contains other interesting chemical elements:

Fluorine	(F)	15 atoms
Bromine	(Br)	5 atoms
Calcium	(Ca)	10 atoms

The binding sites of Chlorine atom in the Halothane Binds to Druggable Sites in Calcium-Calmodulin: Solution Structure of Halothane-Cam C-Terminal Domain (pdb code 2kuh). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Halothane Binds to Druggable Sites in Calcium-Calmodulin: Solution Structure of Halothane-Cam C-Terminal Domain, PDB code: 2kuh:

Chlorine binding site 1 out of 1 in the Halothane Binds to Druggable Sites in Calcium-Calmodulin: Solution Structure of Halothane-Cam C-Terminal Domain


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Halothane Binds to Druggable Sites in Calcium-Calmodulin: Solution Structure of Halothane-Cam C-Terminal Domain within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl150 b:0.0 occ:1.00 CL A:HLT150 0.0 0.0 1.0 C1 A:HLT150 1.8 63.7 1.0 HE1 A:MET109 2.3 0.0 1.0 HC1 A:HLT150 2.4 0.0 1.0 C2 A:HLT150 2.7 64.5 1.0 BR A:HLT150 2.9 0.0 1.0 F1 A:HLT150 3.0 0.0 1.0 F3 A:HLT150 3.0 0.0 1.0 CE A:MET109 3.1 0.1 1.0 HE2 A:MET109 3.2 0.0 1.0 HD12 A:LEU116 3.4 0.0 1.0 SD A:MET109 3.5 0.1 1.0 HE3 A:MET124 3.6 0.0 1.0 HD11 A:LEU116 3.6 0.0 1.0 HG3 A:MET109 3.6 0.0 1.0 HD13 A:LEU105 3.9 0.0 1.0 HG3 A:MET124 3.9 0.0 1.0 F2 A:HLT150 3.9 0.0 1.0 CD1 A:LEU116 4.0 3.4 1.0 HE3 A:MET109 4.1 0.0 1.0 HD11 A:LEU105 4.1 0.0 1.0 HD21 A:LEU116 4.2 0.0 1.0 SD A:MET124 4.2 1.6 1.0 CG A:MET109 4.2 0.1 1.0 CE A:MET124 4.2 1.8 1.0 HD22 A:LEU116 4.3 0.0 1.0 HE2 A:MET124 4.5 0.0 1.0 CD1 A:LEU105 4.5 0.1 1.0 CG A:MET124 4.6 0.2 1.0 CD2 A:LEU116 4.7 3.8 1.0 HD13 A:LEU116 4.7 0.0 1.0 HG2 A:MET109 4.8 0.0 1.0 HG2 A:MET124 5.0 0.0 1.0 HD12 A:LEU105 5.0 0.0 1.0

N.O.Juranic, K.A.Jones, A.R.Penheiter, T.J.Hock, J.H.Streiff. Halothane Binds to Druggable Sites in the [CA2+]4-Calmodulin (Cam) Complex, But Does Not Inhibit [CA2+]4-Cam Activation of Kinase. J. Serb. Chem. Soc. V. 78 1655 2013.
ISSN: ISSN 0352-5139