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Chlorine in PDB 2ot1: Fructose-1,6-Bisphosphate Aldolase From Rabbit Muscle in Complex with Naphthol As-E Phosphate, A Competitive Inhibitor

Enzymatic activity of Fructose-1,6-Bisphosphate Aldolase From Rabbit Muscle in Complex with Naphthol As-E Phosphate, A Competitive Inhibitor

All present enzymatic activity of Fructose-1,6-Bisphosphate Aldolase From Rabbit Muscle in Complex with Naphthol As-E Phosphate, A Competitive Inhibitor:
4.1.2.13;

Protein crystallography data

The structure of Fructose-1,6-Bisphosphate Aldolase From Rabbit Muscle in Complex with Naphthol As-E Phosphate, A Competitive Inhibitor, PDB code: 2ot1 was solved by M.St-Jean, T.Izard, J.Sygusch, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 50.00 / 2.05
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 84.780, 103.445, 83.601, 90.00, 98.66, 90.00
R / Rfree (%) 14.9 / 19.7

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Fructose-1,6-Bisphosphate Aldolase From Rabbit Muscle in Complex with Naphthol As-E Phosphate, A Competitive Inhibitor (pdb code 2ot1). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 4 binding sites of Chlorine where determined in the Fructose-1,6-Bisphosphate Aldolase From Rabbit Muscle in Complex with Naphthol As-E Phosphate, A Competitive Inhibitor, PDB code: 2ot1:
Jump to Chlorine binding site number: 1; 2; 3; 4;

Chlorine binding site 1 out of 4 in 2ot1

Go back to Chlorine Binding Sites List in 2ot1
Chlorine binding site 1 out of 4 in the Fructose-1,6-Bisphosphate Aldolase From Rabbit Muscle in Complex with Naphthol As-E Phosphate, A Competitive Inhibitor


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Fructose-1,6-Bisphosphate Aldolase From Rabbit Muscle in Complex with Naphthol As-E Phosphate, A Competitive Inhibitor within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl3001

b:56.2
occ:1.00
 CLA A:N3P3001 0.0 56.2 1.0
CAS A:N3P3001 1.7 57.0 1.0
CAH A:N3P3001 2.7 56.0 1.0
CAI A:N3P3001 2.7 57.2 1.0
O A:HOH3184 3.7 51.0 1.0
CAJ A:N3P3001 4.0 56.4 1.0
CAK A:N3P3001 4.0 57.1 1.0
CAT A:N3P3001 4.5 56.2 1.0
O A:HOH3447 4.7 41.5 1.0

Chlorine binding site 2 out of 4 in 2ot1

Go back to Chlorine Binding Sites List in 2ot1
Chlorine binding site 2 out of 4 in the Fructose-1,6-Bisphosphate Aldolase From Rabbit Muscle in Complex with Naphthol As-E Phosphate, A Competitive Inhibitor


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Fructose-1,6-Bisphosphate Aldolase From Rabbit Muscle in Complex with Naphthol As-E Phosphate, A Competitive Inhibitor within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl3002

b:61.0
occ:1.00
 CLA B:N3P3002 0.0 61.0 1.0
CAS B:N3P3002 1.7 61.3 1.0
CAH B:N3P3002 2.7 60.5 1.0
CAI B:N3P3002 2.7 60.8 1.0
CAK B:N3P3002 4.0 60.2 1.0
CAJ B:N3P3002 4.0 60.4 1.0
CAT B:N3P3002 4.5 59.8 1.0
O B:HOH3168 4.6 54.0 1.0
O B:HOH3344 4.8 60.7 1.0

Chlorine binding site 3 out of 4 in 2ot1

Go back to Chlorine Binding Sites List in 2ot1
Chlorine binding site 3 out of 4 in the Fructose-1,6-Bisphosphate Aldolase From Rabbit Muscle in Complex with Naphthol As-E Phosphate, A Competitive Inhibitor


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Fructose-1,6-Bisphosphate Aldolase From Rabbit Muscle in Complex with Naphthol As-E Phosphate, A Competitive Inhibitor within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Cl3003

b:60.9
occ:1.00
 CLA C:N3P3003 0.0 60.9 1.0
CAS C:N3P3003 1.7 60.9 1.0
CAH C:N3P3003 2.7 61.0 1.0
CAI C:N3P3003 2.7 60.8 1.0
CAK C:N3P3003 4.0 59.4 1.0
CAJ C:N3P3003 4.0 59.8 1.0
CAT C:N3P3003 4.5 58.6 1.0
O C:HOH3010 4.9 56.6 1.0

Chlorine binding site 4 out of 4 in 2ot1

Go back to Chlorine Binding Sites List in 2ot1
Chlorine binding site 4 out of 4 in the Fructose-1,6-Bisphosphate Aldolase From Rabbit Muscle in Complex with Naphthol As-E Phosphate, A Competitive Inhibitor


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Fructose-1,6-Bisphosphate Aldolase From Rabbit Muscle in Complex with Naphthol As-E Phosphate, A Competitive Inhibitor within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Cl3004

b:50.7
occ:1.00
 CLA D:N3P3004 0.0 50.7 1.0
CAS D:N3P3004 1.7 50.7 1.0
CAI D:N3P3004 2.7 50.5 1.0
CAH D:N3P3004 2.7 50.0 1.0
O D:HOH3176 3.2 60.4 1.0
CAJ D:N3P3004 4.0 49.0 1.0
CAK D:N3P3004 4.0 50.1 1.0
CAT D:N3P3004 4.5 49.0 1.0

Reference:

M.St-Jean, T.Izard, J.Sygusch. A Hydrophobic Pocket in the Active Site of Glycolytic Aldolase Mediates Interactions with Wiskott-Aldrich Syndrome Protein. J.Biol.Chem. V. 282 14309 2007.
ISSN: ISSN 0021-9258
PubMed: 17329259
DOI: 10.1074/JBC.M611505200
Page generated: Sat Jul 20 09:43:52 2024

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