Chlorine in PDB 2p6x: Crystal Structure of Human Tyrosine Phosphatase PTPN22

All present enzymatic activity of Crystal Structure of Human Tyrosine Phosphatase PTPN22:
3.1.3.48;

The structure of Crystal Structure of Human Tyrosine Phosphatase PTPN22, PDB code: 2p6x was solved by E.Ugochukwu, E.Salah, A.Barr, L.Shrestha, I.Alfano, N.Burgess-Brown, O.King, C.Umeano, E.Papagrigoriou, A.C.W.Pike, G.Bunkoczi, A.Turnbull, J.Uppenberg, M.Sundstrom, C.H.Arrowsmith, J.Weigelt, A.Edwards, F.Vondelft, S.Knapp, Structural Genomics Consortium (Sgc), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	59.44 / 1.90
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	60.961, 48.442, 119.805, 90.00, 102.84, 90.00
R / Rfree (%)	16.4 / 21.7

The binding sites of Chlorine atom in the Crystal Structure of Human Tyrosine Phosphatase PTPN22 (pdb code 2p6x). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of Human Tyrosine Phosphatase PTPN22, PDB code: 2p6x:

Chlorine binding site 1 out of 1 in the Crystal Structure of Human Tyrosine Phosphatase PTPN22


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Human Tyrosine Phosphatase PTPN22 within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl501 b:79.6 occ:1.00 NE1 B:TRP244 3.5 31.4 1.0 OE1 B:GLN293 3.9 47.0 1.0 CB B:ARG292 4.1 29.9 1.0 CZ2 B:TRP244 4.2 33.9 1.0 CE2 B:TRP244 4.2 44.0 1.0 CG2 B:VAL296 4.4 50.8 1.0 O B:HOH743 4.4 51.5 1.0 N B:GLN293 4.5 37.8 1.0 C B:ARG292 4.5 37.1 1.0 CD1 B:TRP244 4.7 38.8 1.0 O B:ARG292 4.7 38.0 1.0 CA B:GLN293 4.8 37.7 1.0 CZ3 B:TRP210 4.9 49.6 1.0 CD B:ARG292 4.9 42.2 1.0 CA B:ARG292 5.0 31.3 1.0

A.J.Barr, E.Ugochukwu, W.H.Lee, O.N.King, P.Filippakopoulos, I.Alfano, P.Savitsky, N.A.Burgess-Brown, S.Muller, S.Knapp. Large-Scale Structural Analysis of the Classical Human Protein Tyrosine Phosphatome. Cell(Cambridge,Mass.) V. 136 352 2009.
ISSN: ISSN 0092-8674
PubMed: 19167335
DOI: 10.1016/J.CELL.2008.11.038