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Atomistry » Chlorine » PDB 2p5v-2pfx » 2p95 » |
Chlorine in PDB 2p95: Factor Xa in Complex with the Inhibitor 5-Chloro-N-((1R,2S)-2-(4-(2- Oxopyridin-1(2H)-Yl)Benzamido) Cyclopentyl)Thiophene-2-CarboxamideEnzymatic activity of Factor Xa in Complex with the Inhibitor 5-Chloro-N-((1R,2S)-2-(4-(2- Oxopyridin-1(2H)-Yl)Benzamido) Cyclopentyl)Thiophene-2-Carboxamide
All present enzymatic activity of Factor Xa in Complex with the Inhibitor 5-Chloro-N-((1R,2S)-2-(4-(2- Oxopyridin-1(2H)-Yl)Benzamido) Cyclopentyl)Thiophene-2-Carboxamide:
3.4.21.6; Protein crystallography data
The structure of Factor Xa in Complex with the Inhibitor 5-Chloro-N-((1R,2S)-2-(4-(2- Oxopyridin-1(2H)-Yl)Benzamido) Cyclopentyl)Thiophene-2-Carboxamide, PDB code: 2p95
was solved by
C.-H.Chang,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Factor Xa in Complex with the Inhibitor 5-Chloro-N-((1R,2S)-2-(4-(2- Oxopyridin-1(2H)-Yl)Benzamido) Cyclopentyl)Thiophene-2-Carboxamide
(pdb code 2p95). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Factor Xa in Complex with the Inhibitor 5-Chloro-N-((1R,2S)-2-(4-(2- Oxopyridin-1(2H)-Yl)Benzamido) Cyclopentyl)Thiophene-2-Carboxamide, PDB code: 2p95: Chlorine binding site 1 out of 1 in 2p95Go back to Chlorine Binding Sites List in 2p95
Chlorine binding site 1 out
of 1 in the Factor Xa in Complex with the Inhibitor 5-Chloro-N-((1R,2S)-2-(4-(2- Oxopyridin-1(2H)-Yl)Benzamido) Cyclopentyl)Thiophene-2-Carboxamide
Mono view Stereo pair view
Reference:
J.X.Qiao,
C.-H.Chang,
D.L.Cheney,
P.E.Morin,
G.Z.Wang,
S.R.King,
T.C.Wang,
A.R.Rendina,
J.M.Luettgen,
R.M.Knabb,
R.R.Wexler,
P.Y.S.Lam.
Sar and X-Ray Structures of Enantiopure 1,2-Cis-(1R,2S)-Cyclopentyldiamine and Cyclohexyldiamine Derivatives As Inhibitors of Coagulation Factor Xa Bioorg.Med.Chem.Lett. V. 17 4419 2007.
Page generated: Sat Dec 12 09:14:55 2020
ISSN: ISSN 0960-894X PubMed: 17588746 DOI: 10.1016/J.BMCL.2007.06.029 |
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