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Chlorine in PDB 2pf8: Complex of Aldose Reductase with Nadp+ and Simaltaneously Bound Competetive Inhibitors Fidarestat and IDD594. Concentration of Fidarestat in Soaking Solution Is Equal to Concentration of IDD594.

Enzymatic activity of Complex of Aldose Reductase with Nadp+ and Simaltaneously Bound Competetive Inhibitors Fidarestat and IDD594. Concentration of Fidarestat in Soaking Solution Is Equal to Concentration of IDD594.

All present enzymatic activity of Complex of Aldose Reductase with Nadp+ and Simaltaneously Bound Competetive Inhibitors Fidarestat and IDD594. Concentration of Fidarestat in Soaking Solution Is Equal to Concentration of IDD594.:
1.1.1.21;

Protein crystallography data

The structure of Complex of Aldose Reductase with Nadp+ and Simaltaneously Bound Competetive Inhibitors Fidarestat and IDD594. Concentration of Fidarestat in Soaking Solution Is Equal to Concentration of IDD594., PDB code: 2pf8 was solved by T.Petrova, I.Hazemann, A.Cousido, A.Mitschler, S.Ginell, A.Joachimiak, A.Podjarny, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 50.00 / 0.85
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 49.339, 66.815, 47.378, 90.00, 92.10, 90.00
R / Rfree (%) 8.5 / 9.5

Other elements in 2pf8:

The structure of Complex of Aldose Reductase with Nadp+ and Simaltaneously Bound Competetive Inhibitors Fidarestat and IDD594. Concentration of Fidarestat in Soaking Solution Is Equal to Concentration of IDD594. also contains other interesting chemical elements:

Fluorine (F) 3 atoms
Bromine (Br) 1 atom

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Complex of Aldose Reductase with Nadp+ and Simaltaneously Bound Competetive Inhibitors Fidarestat and IDD594. Concentration of Fidarestat in Soaking Solution Is Equal to Concentration of IDD594. (pdb code 2pf8). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Complex of Aldose Reductase with Nadp+ and Simaltaneously Bound Competetive Inhibitors Fidarestat and IDD594. Concentration of Fidarestat in Soaking Solution Is Equal to Concentration of IDD594., PDB code: 2pf8:

Chlorine binding site 1 out of 1 in 2pf8

Go back to Chlorine Binding Sites List in 2pf8
Chlorine binding site 1 out of 1 in the Complex of Aldose Reductase with Nadp+ and Simaltaneously Bound Competetive Inhibitors Fidarestat and IDD594. Concentration of Fidarestat in Soaking Solution Is Equal to Concentration of IDD594.


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Complex of Aldose Reductase with Nadp+ and Simaltaneously Bound Competetive Inhibitors Fidarestat and IDD594. Concentration of Fidarestat in Soaking Solution Is Equal to Concentration of IDD594. within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl2000

b:3.6
occ:0.28
 O A:HOH2001 0.1 8.8 0.7
ND1 A:HIS110 2.9 3.6 1.0
O A:LYS77 3.0 4.0 1.0
N A:VAL47 3.2 3.7 1.0
N A:HIS46 3.4 3.6 1.0
CB A:TRP79 3.5 4.1 1.0
CB A:ALA45 3.5 3.7 1.0
N A:TRP79 3.6 3.8 1.0
CB A:VAL47 3.7 3.9 1.0
CG1 A:VAL47 3.7 4.3 1.0
CA A:TRP79 3.7 3.9 1.0
CE3 A:TRP79 3.7 4.1 1.0
CE1 A:HIS110 3.7 3.9 1.0
C A:LYS77 3.8 3.3 1.0
CB A:HIS46 4.0 4.3 1.0
CA A:HIS46 4.0 3.8 1.0
C A:LEU78 4.0 3.4 1.0
C A:ALA45 4.1 3.4 1.0
CG A:HIS110 4.1 3.6 1.0
CA A:VAL47 4.1 3.9 1.0
CB A:LYS77 4.1 3.5 1.0
C A:HIS46 4.1 3.8 1.0
CA A:ALA45 4.1 3.3 1.0
CG A:TRP79 4.2 4.2 1.0
CD2 A:TRP79 4.3 4.3 1.0
O A:HOH2061 4.3 5.7 1.0
CB A:HIS110 4.4 3.6 1.0
N A:LEU78 4.5 3.4 1.0
O A:LEU78 4.5 3.9 1.0
CA A:LYS77 4.5 3.3 1.0
CA A:LEU78 4.7 3.6 1.0
CZ3 A:TRP79 4.7 4.8 1.0
O A:ALA45 4.9 3.8 1.0
O A:HOH2060 4.9 5.1 1.0
NE2 A:HIS110 5.0 3.8 1.0
N A:LYS77 5.0 3.2 1.0

Reference:

A.Cousido-Siah, T.Petrova, I.Hazemann, A.Mitschler, F.X.Ruiz, E.Howard, S.Ginell, C.Atmanene, A.Van Dorsselaer, S.Sanglier-Cianferani, A.Joachimiak, A.Podjarny. Crystal Packing Modifies Ligand Binding Affinity: the Case of Aldose Reductase. Proteins V. 80 2552 2012.
ISSN: ISSN 0887-3585
PubMed: 22752989
DOI: 10.1002/PROT.24136
Page generated: Sat Jul 20 10:07:56 2024

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