Chlorine in PDB 2pfi: Crystal Structure of the Cytoplasmic Domain of the Human Chloride Channel Clc-Ka

The structure of Crystal Structure of the Cytoplasmic Domain of the Human Chloride Channel Clc-Ka, PDB code: 2pfi was solved by S.Markovic, R.Dutzler, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	14.89 / 1.60
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	35.283, 83.421, 59.888, 90.00, 92.48, 90.00
R / Rfree (%)	20 / 21.8

The structure of Crystal Structure of the Cytoplasmic Domain of the Human Chloride Channel Clc-Ka also contains other interesting chemical elements:

Iodine

(I)

1 atom

The binding sites of Chlorine atom in the Crystal Structure of the Cytoplasmic Domain of the Human Chloride Channel Clc-Ka (pdb code 2pfi). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 3 binding sites of Chlorine where determined in the Crystal Structure of the Cytoplasmic Domain of the Human Chloride Channel Clc-Ka, PDB code: 2pfi:
Jump to Chlorine binding site number: 1; 2; 3;

Chlorine binding site 1 out of 3 in the Crystal Structure of the Cytoplasmic Domain of the Human Chloride Channel Clc-Ka


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of the Cytoplasmic Domain of the Human Chloride Channel Clc-Ka within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl504 b:24.2 occ:1.00 O A:HOH52 3.1 31.2 1.0 ND2 A:ASN679 3.8 29.6 1.0 CB A:PHE550 4.0 19.3 1.0 O A:HIS549 4.2 19.8 1.0 CA A:ALA676 4.2 23.0 1.0 CB A:ALA676 4.3 21.8 1.0 CB A:HIS549 4.4 19.7 1.0 CG1 A:VAL545 4.4 20.0 1.0 CB A:ASN679 4.5 28.9 1.0 C A:HIS549 4.5 18.8 1.0 CA A:PHE550 4.6 16.0 1.0 CG A:ASN679 4.7 30.8 1.0 N A:PHE550 4.7 17.1 1.0 O A:ALA676 4.9 25.0 1.0 CD2 A:PHE550 4.9 15.6 1.0 O A:HOH192 4.9 47.4 1.0 CG A:PHE550 4.9 17.0 1.0

Chlorine binding site 2 out of 3 in the Crystal Structure of the Cytoplasmic Domain of the Human Chloride Channel Clc-Ka


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of the Cytoplasmic Domain of the Human Chloride Channel Clc-Ka within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl502 b:28.6 occ:1.00 O B:HOH37 3.4 32.0 1.0 O B:HOH195 3.5 42.1 1.0 ND2 B:ASN679 3.8 34.6 1.0 CB B:PHE550 4.0 18.4 1.0 O B:HIS549 4.1 21.1 1.0 O B:HOH268 4.2 56.0 1.0 CA B:ALA676 4.2 28.9 1.0 CB B:ALA676 4.3 26.8 1.0 CB B:HIS549 4.3 17.9 1.0 C B:HIS549 4.4 20.1 1.0 CG1 B:VAL545 4.5 20.9 1.0 CA B:PHE550 4.6 19.4 1.0 N B:PHE550 4.6 18.0 1.0 CB B:ASN679 4.7 36.1 1.0 CG B:ASN679 4.7 38.7 1.0 CD2 B:PHE550 4.9 20.3 1.0 O B:ALA676 4.9 28.8 1.0 CG B:PHE550 4.9 18.9 1.0

Chlorine binding site 3 out of 3 in the Crystal Structure of the Cytoplasmic Domain of the Human Chloride Channel Clc-Ka


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Crystal Structure of the Cytoplasmic Domain of the Human Chloride Channel Clc-Ka within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl503 b:35.9 occ:1.00 CD1 B:ILE677 3.3 30.8 1.0 CZ3 B:TRP670 3.6 28.1 1.0 OE1 B:GLN645 3.9 37.4 1.0 CG B:GLN645 4.4 34.1 1.0 CH2 B:TRP670 4.4 25.9 1.0 CE3 B:TRP670 4.4 30.9 1.0 CD B:GLN645 4.6 42.4 1.0 CG1 B:ILE677 4.7 25.8 1.0 CG B:LYS674 4.9 32.8 1.0

S.Markovic, R.Dutzler. The Structure of the Cytoplasmic Domain of the Chloride Channel Clc-Ka Reveals A Conserved Interaction Interface. Structure V. 15 715 2007.
ISSN: ISSN 0969-2126
PubMed: 17562318
DOI: 10.1016/J.STR.2007.04.013