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Chlorine in PDB 2pou: The Crystal Structure of the Human Carbonic Anhydrase II in Complex with 4,5-Dichloro-Benzene-1,3-Disulfonamide
Enzymatic activity of The Crystal Structure of the Human Carbonic Anhydrase II in Complex with 4,5-Dichloro-Benzene-1,3-Disulfonamide
All present enzymatic activity of The Crystal Structure of the Human Carbonic Anhydrase II in Complex with 4,5-Dichloro-Benzene-1,3-Disulfonamide:
4.2.1.1;
4.2.1.1;
Protein crystallography data
The structure of The Crystal Structure of the Human Carbonic Anhydrase II in Complex with 4,5-Dichloro-Benzene-1,3-Disulfonamide, PDB code: 2pou
was solved by
V.Alterio,
G.De Simone,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 20.00 / 1.60 |
| Space group | P 1 21 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 41.910, 41.300, 71.740, 90.00, 104.31, 90.00 |
| R / Rfree (%) | 19.3 / 22.4 |
Other elements in 2pou:
The structure of The Crystal Structure of the Human Carbonic Anhydrase II in Complex with 4,5-Dichloro-Benzene-1,3-Disulfonamide also contains other interesting chemical elements:
| Zinc | (Zn) | 1 atom |
Chlorine Binding Sites:
The binding sites of Chlorine atom in the The Crystal Structure of the Human Carbonic Anhydrase II in Complex with 4,5-Dichloro-Benzene-1,3-Disulfonamide
(pdb code 2pou). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the The Crystal Structure of the Human Carbonic Anhydrase II in Complex with 4,5-Dichloro-Benzene-1,3-Disulfonamide, PDB code: 2pou:
Jump to Chlorine binding site number: 1; 2;
In total 2 binding sites of Chlorine where determined in the The Crystal Structure of the Human Carbonic Anhydrase II in Complex with 4,5-Dichloro-Benzene-1,3-Disulfonamide, PDB code: 2pou:
Jump to Chlorine binding site number: 1; 2;
Chlorine binding site 1 out of 2 in 2pou
Go back to
Chlorine Binding Sites List in 2pou
Chlorine binding site 1 out
of 2 in the The Crystal Structure of the Human Carbonic Anhydrase II in Complex with 4,5-Dichloro-Benzene-1,3-Disulfonamide
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 1 of The Crystal Structure of the Human Carbonic Anhydrase II in Complex with 4,5-Dichloro-Benzene-1,3-Disulfonamide within 5.0Å range:
|
Chlorine binding site 2 out of 2 in 2pou
Go back to
Chlorine Binding Sites List in 2pou
Chlorine binding site 2 out
of 2 in the The Crystal Structure of the Human Carbonic Anhydrase II in Complex with 4,5-Dichloro-Benzene-1,3-Disulfonamide
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 2 of The Crystal Structure of the Human Carbonic Anhydrase II in Complex with 4,5-Dichloro-Benzene-1,3-Disulfonamide within 5.0Å range:
|
Reference:
V.Alterio,
G.De Simone,
S.M.Monti,
A.Scozzafava,
C.T.Supuran.
Carbonic Anhydrase Inhibitors: Inhibition of Human, Bacterial, and Archaeal Isozymes with Benzene-1,3-Disulfonamides-Solution and Crystallographic Studies. Bioorg.Med.Chem.Lett. V. 17 4201 2007.
ISSN: ISSN 0960-894X
PubMed: 17540563
DOI: 10.1016/J.BMCL.2007.05.045
Page generated: Sat Dec 12 09:15:37 2020
ISSN: ISSN 0960-894X
PubMed: 17540563
DOI: 10.1016/J.BMCL.2007.05.045
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