Atomistry » Chlorine » PDB 2pg4-2pwr » 2pvw
Atomistry »
  Chlorine »
    PDB 2pg4-2pwr »
      2pvw »

Chlorine in PDB 2pvw: A High Resolution Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with 2-(Phosphonomethyl)Pentanedioic Acid (2-Pmpa)

Enzymatic activity of A High Resolution Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with 2-(Phosphonomethyl)Pentanedioic Acid (2-Pmpa)

All present enzymatic activity of A High Resolution Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with 2-(Phosphonomethyl)Pentanedioic Acid (2-Pmpa):
3.4.17.21;

Protein crystallography data

The structure of A High Resolution Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with 2-(Phosphonomethyl)Pentanedioic Acid (2-Pmpa), PDB code: 2pvw was solved by C.Barinka, J.Lubkowski, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 15.00 / 1.71
Space group I 2 2 2
Cell size a, b, c (Å), α, β, γ (°) 101.849, 130.822, 159.452, 90.00, 90.00, 90.00
R / Rfree (%) 18.2 / 20.7

Other elements in 2pvw:

The structure of A High Resolution Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with 2-(Phosphonomethyl)Pentanedioic Acid (2-Pmpa) also contains other interesting chemical elements:

Calcium (Ca) 1 atom
Zinc (Zn) 2 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the A High Resolution Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with 2-(Phosphonomethyl)Pentanedioic Acid (2-Pmpa) (pdb code 2pvw). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the A High Resolution Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with 2-(Phosphonomethyl)Pentanedioic Acid (2-Pmpa), PDB code: 2pvw:

Chlorine binding site 1 out of 1 in 2pvw

Go back to Chlorine Binding Sites List in 2pvw
Chlorine binding site 1 out of 1 in the A High Resolution Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with 2-(Phosphonomethyl)Pentanedioic Acid (2-Pmpa)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of A High Resolution Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with 2-(Phosphonomethyl)Pentanedioic Acid (2-Pmpa) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl1754

b:35.5
occ:1.00
O A:HOH1788 3.1 35.8 1.0
ND2 A:ASN451 3.3 26.9 1.0
NE A:ARG534 3.3 36.3 1.0
NH2 A:ARG536 3.4 22.1 0.3
N A:ASP453 3.4 26.4 1.0
NH1 A:ARG534 3.5 37.2 1.0
CB A:ASP453 3.8 25.2 1.0
CB A:ARG534 3.8 26.9 1.0
CZ A:ARG534 3.9 37.2 1.0
NH2 A:ARG580 4.0 27.9 1.0
CA A:ASP453 4.0 27.2 1.0
CB A:ASN451 4.1 24.0 1.0
CG A:ASN451 4.1 25.0 1.0
N A:ALA452 4.2 24.2 1.0
C A:ASP453 4.3 28.7 1.0
CZ A:ARG536 4.3 26.2 0.3
NE A:ARG536 4.3 25.4 0.3
C A:ASN451 4.3 24.0 1.0
O A:ASP453 4.4 30.2 1.0
C A:ALA452 4.4 26.9 1.0
CA A:ALA452 4.4 25.8 1.0
CD A:ARG536 4.4 34.3 0.7
CD A:ARG534 4.5 35.5 1.0
O A:ASN451 4.5 27.6 1.0
CG A:ARG534 4.5 28.8 1.0
O A:SER454 4.7 31.8 1.0
CZ A:ARG580 4.8 29.2 1.0
CA A:ARG534 4.8 25.9 1.0
NE A:ARG536 4.8 35.0 0.7
O A:ALA535 4.9 26.6 1.0
CA A:ASN451 4.9 23.3 1.0
N A:ALA535 4.9 25.2 1.0
N A:SER454 4.9 29.1 1.0

Reference:

C.Barinka, M.Rovenska, P.Mlcochova, K.Hlouchova, A.Plechanovova, P.Majer, T.Tsukamoto, B.S.Slusher, J.Konvalinka, J.Lubkowski. Structural Insight Into the Pharmacophore Pocket of Human Glutamate Carboxypeptidase II. J.Med.Chem. V. 50 3267 2007.
ISSN: ISSN 0022-2623
PubMed: 17567119
DOI: 10.1021/JM070133W
Page generated: Sat Dec 12 09:15:48 2020

Last articles

Zn in 7VD8
Zn in 7V1R
Zn in 7V1Q
Zn in 7VPF
Zn in 7T85
Zn in 7T5F
Zn in 7NF9
Zn in 7M4M
Zn in 7M4O
Zn in 7M4N
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy