Chlorine in PDB 2q7m: Crystal Structure of Human Flap with Mk-591

The structure of Crystal Structure of Human Flap with Mk-591, PDB code: 2q7m was solved by A.D.Ferguson, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	20.00 / 4.25
Space group	P 4 21 2
Cell size a, b, c (Å), α, β, γ (°)	180.600, 180.600, 140.570, 90.00, 90.00, 90.00
R / Rfree (%)	24.2 / 28.3

The binding sites of Chlorine atom in the Crystal Structure of Human Flap with Mk-591 (pdb code 2q7m). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 6 binding sites of Chlorine where determined in the Crystal Structure of Human Flap with Mk-591, PDB code: 2q7m:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5; 6;

Chlorine binding site 1 out of 6 in the Crystal Structure of Human Flap with Mk-591


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Human Flap with Mk-591 within 5.0Å range: probe atom residue distance (Å) B Occ C:Cl501 b:0.9 occ:1.00 CL17 C:2CS501 0.0 0.9 1.0 C16 C:2CS501 1.7 0.8 1.0 C15 C:2CS501 2.5 0.7 1.0 C13 C:2CS501 2.7 0.6 1.0 CB C:PHE25 2.8 0.7 1.0 CA C:PHE25 3.1 0.3 1.0 CG C:PHE25 3.4 0.4 1.0 CD1 C:PHE25 3.6 0.8 1.0 N C:PHE25 3.7 0.3 1.0 C14 C:2CS501 3.8 0.7 1.0 C12 C:2CS501 3.9 0.6 1.0 O C:VAL21 4.2 0.7 1.0 C11 C:2CS501 4.3 0.7 1.0 CD2 C:PHE25 4.3 0.1 1.0 C C:PHE25 4.4 0.0 1.0 C C:GLY24 4.4 0.1 1.0 O C:GLY24 4.6 0.8 1.0 CE1 C:PHE25 4.7 0.6 1.0 O C:PHE25 4.9 0.2 1.0

Chlorine binding site 2 out of 6 in the Crystal Structure of Human Flap with Mk-591


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of Human Flap with Mk-591 within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl502 b:1.0 occ:1.00 CL17 A:2CS502 0.0 1.0 1.0 C16 A:2CS502 1.7 0.8 1.0 C13 A:2CS502 2.6 0.8 1.0 C15 A:2CS502 2.6 0.7 1.0 C12 A:2CS502 3.9 0.7 1.0 C14 A:2CS502 3.9 0.7 1.0 CB A:PHE25 4.2 0.7 1.0 C11 A:2CS502 4.3 0.7 1.0 CG A:PHE25 4.6 0.5 1.0 CD1 A:PHE25 4.8 0.7 1.0

Chlorine binding site 3 out of 6 in the Crystal Structure of Human Flap with Mk-591


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Crystal Structure of Human Flap with Mk-591 within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl503 b:0.6 occ:1.00 CL17 A:2CS503 0.0 0.6 1.0 C16 A:2CS503 1.7 0.5 1.0 C13 A:2CS503 2.6 0.4 1.0 C15 A:2CS503 2.7 0.4 1.0 CB B:PHE25 2.9 0.6 1.0 CA B:PHE25 3.4 0.4 1.0 CG B:PHE25 3.5 0.1 1.0 CD1 B:PHE25 3.8 0.4 1.0 C12 A:2CS503 3.9 0.4 1.0 N B:PHE25 3.9 0.6 1.0 C14 A:2CS503 4.0 0.3 1.0 O B:VAL21 4.2 0.7 1.0 C11 A:2CS503 4.4 0.3 1.0 CD2 B:PHE25 4.6 0.5 1.0 O5 A:2CS503 4.6 0.4 1.0 C B:PHE25 4.7 0.6 1.0 C B:GLY24 4.8 0.0 1.0 CE1 B:PHE25 4.9 0.5 1.0

Chlorine binding site 4 out of 6 in the Crystal Structure of Human Flap with Mk-591


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Crystal Structure of Human Flap with Mk-591 within 5.0Å range: probe atom residue distance (Å) B Occ D:Cl504 b:0.0 occ:1.00 CL17 D:2CS504 0.0 0.0 1.0 C16 D:2CS504 1.7 0.9 1.0 C15 D:2CS504 2.6 0.9 1.0 C13 D:2CS504 2.6 0.8 1.0 CB D:PHE25 3.6 0.5 1.0 C14 D:2CS504 3.9 0.8 1.0 C12 D:2CS504 3.9 0.8 1.0 CA D:PHE25 4.1 0.2 1.0 O D:VAL21 4.2 0.3 1.0 C11 D:2CS504 4.4 0.8 1.0 CG D:PHE25 4.4 1.0 1.0 N D:PHE25 4.5 0.2 1.0 CD1 D:PHE25 4.7 0.4 1.0 CG2 D:VAL21 4.9 1.0 1.0

Chlorine binding site 5 out of 6 in the Crystal Structure of Human Flap with Mk-591


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 5 of Crystal Structure of Human Flap with Mk-591 within 5.0Å range: probe atom residue distance (Å) B Occ E:Cl505 b:0.7 occ:1.00 CL17 E:2CS505 0.0 0.7 1.0 C16 E:2CS505 1.7 0.6 1.0 C15 E:2CS505 2.6 0.5 1.0 C13 E:2CS505 2.7 0.4 1.0 CB E:PHE25 2.8 0.3 1.0 CD1 E:PHE25 3.0 0.2 1.0 CG E:PHE25 3.3 0.0 1.0 CA E:PHE25 3.3 0.2 1.0 C14 E:2CS505 3.9 0.5 1.0 C12 E:2CS505 3.9 0.4 1.0 N E:PHE25 4.0 0.3 1.0 O E:VAL21 4.2 0.5 1.0 CE1 E:PHE25 4.2 0.7 1.0 C11 E:2CS505 4.4 0.4 1.0 CD2 E:PHE25 4.6 0.4 1.0 C E:PHE25 4.6 0.5 1.0 C E:GLY24 4.9 0.1 1.0

Chlorine binding site 6 out of 6 in the Crystal Structure of Human Flap with Mk-591


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 6 of Crystal Structure of Human Flap with Mk-591 within 5.0Å range: probe atom residue distance (Å) B Occ E:Cl506 b:0.6 occ:1.00 CL17 E:2CS506 0.0 0.6 1.0 C16 E:2CS506 1.7 0.5 1.0 C15 E:2CS506 2.7 0.4 1.0 C13 E:2CS506 2.7 0.4 1.0 CB F:PHE25 2.8 0.2 1.0 CG F:PHE25 3.4 0.2 1.0 CA F:PHE25 3.8 0.8 1.0 CD1 F:PHE25 3.9 0.2 1.0 C14 E:2CS506 4.0 0.4 1.0 C12 E:2CS506 4.0 0.4 1.0 CD2 F:PHE25 4.1 0.5 1.0 N F:PHE25 4.5 1.0 1.0 C11 E:2CS506 4.5 0.4 1.0 O F:VAL21 4.6 0.5 1.0 CE1 F:PHE25 4.9 0.4 1.0

A.D.Ferguson, B.M.Mckeever, S.Xu, D.Wisniewski, D.K.Miller, T.T.Yamin, R.H.Spencer, L.Chu, F.Ujjainwalla, B.R.Cunningham, J.F.Evans, J.W.Becker. Crystal Structure of Inhibitor-Bound Human 5-Lipoxygenase-Activating Protein. Science V. 317 510 2007.
ISSN: ISSN 0036-8075
PubMed: 17600184
DOI: 10.1126/SCIENCE.1144346