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Chlorine in PDB 2q8m: T-Like Fructose-1,6-Bisphosphatase From Escherichia Coli with Amp, Glucose 6-Phosphate, and Fructose 1,6-Bisphosphate Bound

Enzymatic activity of T-Like Fructose-1,6-Bisphosphatase From Escherichia Coli with Amp, Glucose 6-Phosphate, and Fructose 1,6-Bisphosphate Bound

All present enzymatic activity of T-Like Fructose-1,6-Bisphosphatase From Escherichia Coli with Amp, Glucose 6-Phosphate, and Fructose 1,6-Bisphosphate Bound:
3.1.3.11;

Protein crystallography data

The structure of T-Like Fructose-1,6-Bisphosphatase From Escherichia Coli with Amp, Glucose 6-Phosphate, and Fructose 1,6-Bisphosphate Bound, PDB code: 2q8m was solved by J.K.Hines, C.E.Kruesel, H.J.Fromm, R.B.Honzatko, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 37.77 / 2.05
Space group P 41 2 2
Cell size a, b, c (Å), α, β, γ (°) 124.640, 124.640, 132.280, 90.00, 90.00, 90.00
R / Rfree (%) 20.9 / 23.5

Other elements in 2q8m:

The structure of T-Like Fructose-1,6-Bisphosphatase From Escherichia Coli with Amp, Glucose 6-Phosphate, and Fructose 1,6-Bisphosphate Bound also contains other interesting chemical elements:

Magnesium (Mg) 4 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the T-Like Fructose-1,6-Bisphosphatase From Escherichia Coli with Amp, Glucose 6-Phosphate, and Fructose 1,6-Bisphosphate Bound (pdb code 2q8m). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 3 binding sites of Chlorine where determined in the T-Like Fructose-1,6-Bisphosphatase From Escherichia Coli with Amp, Glucose 6-Phosphate, and Fructose 1,6-Bisphosphate Bound, PDB code: 2q8m:
Jump to Chlorine binding site number: 1; 2; 3;

Chlorine binding site 1 out of 3 in 2q8m

Go back to Chlorine Binding Sites List in 2q8m
Chlorine binding site 1 out of 3 in the T-Like Fructose-1,6-Bisphosphatase From Escherichia Coli with Amp, Glucose 6-Phosphate, and Fructose 1,6-Bisphosphate Bound


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of T-Like Fructose-1,6-Bisphosphatase From Escherichia Coli with Amp, Glucose 6-Phosphate, and Fructose 1,6-Bisphosphate Bound within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl350

b:55.7
occ:1.00
 N A:PHE187 3.3 26.9 1.0
CE A:LYS30 3.4 32.1 1.0
N A:GLY5 3.7 22.3 1.0
CB A:VAL186 3.7 31.8 1.0
O A:PHE187 3.8 25.0 1.0
CB A:LEU4 3.9 17.9 1.0
N A:LEU4 3.9 22.6 1.0
CA A:VAL186 3.9 30.5 1.0
CD A:LYS30 3.9 32.0 1.0
CB A:PHE187 4.1 22.3 1.0
C A:VAL186 4.1 28.9 1.0
CA A:PHE187 4.1 25.0 1.0
CB A:THR3 4.2 26.2 1.0
O A:HOH416 4.3 50.0 0.5
CA A:LEU4 4.3 22.1 1.0
CG1 A:VAL186 4.3 33.4 1.0
NZ A:LYS34 4.3 42.6 1.0
C A:PHE187 4.4 25.0 1.0
C A:LEU4 4.5 22.4 1.0
CA A:GLY5 4.5 23.2 1.0
CD2 A:PHE187 4.5 22.1 1.0
CE A:LYS34 4.5 40.3 1.0
OG1 A:THR3 4.7 26.1 1.0
C A:THR3 4.7 24.9 1.0
NZ A:LYS30 4.7 39.4 1.0
CG A:PHE187 4.8 23.4 1.0
CG2 A:VAL186 4.8 31.7 1.0
CG A:LEU4 4.8 19.1 1.0
CA A:THR3 4.9 25.9 1.0
CG2 A:THR3 5.0 27.1 1.0

Chlorine binding site 2 out of 3 in 2q8m

Go back to Chlorine Binding Sites List in 2q8m
Chlorine binding site 2 out of 3 in the T-Like Fructose-1,6-Bisphosphatase From Escherichia Coli with Amp, Glucose 6-Phosphate, and Fructose 1,6-Bisphosphate Bound


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of T-Like Fructose-1,6-Bisphosphatase From Escherichia Coli with Amp, Glucose 6-Phosphate, and Fructose 1,6-Bisphosphate Bound within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl351

b:63.9
occ:1.00
 O B:HOH551 3.6 39.8 1.0
NZ B:LYS30 3.6 44.1 1.0
NZ A:LYS30 3.7 39.4 1.0
O A:HOH416 3.8 50.0 0.5
CE B:LYS30 4.1 41.4 1.0
CE A:LYS30 4.2 32.1 1.0
O A:HOH433 4.2 50.0 0.5
O B:HOH606 4.3 46.8 1.0
CA A:GLY5 4.4 23.2 1.0
O A:HOH422 4.5 41.8 1.0
O B:HOH486 4.7 29.2 1.0
O B:HOH546 4.8 44.6 1.0
CA B:GLY5 4.8 23.8 1.0
O A:HOH415 4.9 34.0 1.0

Chlorine binding site 3 out of 3 in 2q8m

Go back to Chlorine Binding Sites List in 2q8m
Chlorine binding site 3 out of 3 in the T-Like Fructose-1,6-Bisphosphatase From Escherichia Coli with Amp, Glucose 6-Phosphate, and Fructose 1,6-Bisphosphate Bound


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of T-Like Fructose-1,6-Bisphosphatase From Escherichia Coli with Amp, Glucose 6-Phosphate, and Fructose 1,6-Bisphosphate Bound within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl349

b:49.9
occ:1.00
 N B:PHE187 3.3 26.8 1.0
CE B:LYS30 3.3 41.4 1.0
CA B:VAL186 3.8 29.4 1.0
CD B:LYS30 3.9 39.1 1.0
NZ B:LYS34 3.9 40.3 1.0
N B:GLY5 3.9 23.6 1.0
CB B:VAL186 3.9 31.3 1.0
CB B:LEU4 3.9 21.6 1.0
N B:LEU4 4.0 23.1 1.0
C B:VAL186 4.0 28.3 1.0
CB B:PHE187 4.1 25.2 1.0
O B:PHE187 4.1 26.2 1.0
CE B:LYS34 4.2 37.4 1.0
CA B:PHE187 4.2 26.2 1.0
CD2 B:PHE187 4.3 22.9 1.0
CG1 B:VAL186 4.3 34.1 1.0
CA B:LEU4 4.4 23.4 1.0
O A:HOH416 4.4 50.0 0.5
CB B:THR3 4.5 26.5 1.0
NZ B:LYS30 4.6 44.1 1.0
C B:PHE187 4.6 25.9 1.0
C B:LEU4 4.6 22.1 1.0
CG B:LYS30 4.7 35.7 1.0
CG B:PHE187 4.7 24.2 1.0
O B:GLY185 4.8 35.4 1.0
CA B:GLY5 4.8 23.8 1.0
CG B:LEU4 4.9 23.0 1.0
C B:THR3 4.9 24.2 1.0

Reference:

J.K.Hines, C.E.Kruesel, H.J.Fromm, R.B.Honzatko. Structure of Inhibited Fructose-1,6-Bisphosphatase From Escherichia Coli: Distinct Allosteric Inhibition Sites For Amp and Glucose 6-Phosphate and the Characterization of A Gluconeogenic Switch. J.Biol.Chem. V. 282 24697 2007.
ISSN: ISSN 0021-9258
PubMed: 17567577
DOI: 10.1074/JBC.M703580200
Page generated: Sat Jul 20 10:32:49 2024

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