Chlorine in PDB 2qk4: Human Glycinamide Ribonucleotide Synthetase

All present enzymatic activity of Human Glycinamide Ribonucleotide Synthetase:
6.3.4.13;

The structure of Human Glycinamide Ribonucleotide Synthetase, PDB code: 2qk4 was solved by L.Lehtio, M.Welin, C.H.Arrowsmith, H.Berglund, R.Busam, R.Collins, L.G.Dahlgren, M.D.Herman, A.Edwards, S.Flodin, A.Flores, S.Graslund, M.Hammarstrom, B.M.Hallberg, L.Holmberg-Schiavone, I.Johansson, A.Kallas, T.Karlberg, T.Kotenyova, M.Moche, T.Nyman, C.Persson, J.Sagemark, P.Stenmark, M.Sundstrom, A.G.Thorsell, L.Tresaugues, S.Vanden Berg, J.Weigelt, P.Nordlund, Structural Genomics Consortium (Sgc), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	19.98 / 2.45
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	70.280, 79.810, 113.870, 90.00, 104.07, 90.00
R / Rfree (%)	17.1 / 22.1

The binding sites of Chlorine atom in the Human Glycinamide Ribonucleotide Synthetase (pdb code 2qk4). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Human Glycinamide Ribonucleotide Synthetase, PDB code: 2qk4:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Human Glycinamide Ribonucleotide Synthetase


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Human Glycinamide Ribonucleotide Synthetase within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl602 b:59.3 occ:1.00 N A:GLY84 3.3 48.8 1.0 N A:ALA98 3.3 46.2 1.0 CA A:GLY84 3.3 46.9 1.0 CA A:GLY81 3.6 50.4 1.0 O A:GLY81 3.6 53.8 1.0 CB A:THR97 3.8 48.4 1.0 CB A:ALA98 3.9 44.3 1.0 CA A:THR97 3.9 47.4 1.0 C A:GLY81 3.9 51.8 1.0 O A:HOH805 4.0 47.8 1.0 C A:THR97 4.1 47.8 1.0 CA A:ALA98 4.2 47.4 1.0 CG2 A:THR97 4.4 41.7 1.0 C A:GLY84 4.4 47.5 1.0 C A:VAL83 4.5 49.2 1.0 N A:ASN85 4.6 48.0 1.0 N A:GLY81 4.8 50.8 1.0 N A:VAL83 4.9 49.4 1.0 OG1 A:THR97 4.9 51.9 1.0 N A:ILE82 4.9 51.0 1.0

Chlorine binding site 2 out of 2 in the Human Glycinamide Ribonucleotide Synthetase


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Human Glycinamide Ribonucleotide Synthetase within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl601 b:57.5 occ:1.00 O B:HOH861 3.2 57.7 1.0 N B:GLY84 3.2 45.8 1.0 N B:ALA98 3.2 41.0 1.0 CA B:GLY84 3.4 43.7 1.0 CA B:GLY81 3.6 41.7 1.0 CB B:THR97 3.7 40.9 1.0 CA B:THR97 3.7 38.5 1.0 O B:GLY81 3.8 44.8 1.0 C B:GLY81 4.0 44.7 1.0 C B:THR97 4.0 40.1 1.0 O B:HOH824 4.0 39.0 1.0 CG2 B:THR97 4.1 28.6 1.0 CB B:ALA98 4.2 37.9 1.0 O B:HOH851 4.2 61.5 1.0 CA B:ALA98 4.3 41.0 1.0 C B:VAL83 4.4 43.1 1.0 C B:GLY84 4.5 44.7 1.0 N B:ASN85 4.6 45.1 1.0 N B:VAL83 4.7 42.3 1.0 N B:GLY81 4.8 43.0 1.0 CA B:VAL83 4.9 40.0 1.0 CB B:VAL83 4.9 44.2 1.0 N B:ILE82 5.0 44.3 1.0 OG1 B:THR97 5.0 41.4 1.0

M.Welin, J.G.Grossmann, S.Flodin, T.Nyman, P.Stenmark, L.Tresaugues, T.Kotenyova, I.Johansson, P.Nordlund, L.Lehtio. Structural Studies of Tri-Functional Human Gart. Nucleic Acids Res. V. 38 7308 2010.
ISSN: ISSN 0305-1048
PubMed: 20631005
DOI: 10.1093/NAR/GKQ595