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Chlorine in PDB 2qts: Structure of An Acid-Sensing Ion Channel 1 at 1.9 A Resolution and Low pH

Protein crystallography data

The structure of Structure of An Acid-Sensing Ion Channel 1 at 1.9 A Resolution and Low pH, PDB code: 2qts was solved by J.Jasti, H.Furukawa, E.B.Gonzales, E.Gouaux, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 30.00 / 1.90
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 124.252, 110.781, 149.891, 90.00, 97.54, 90.00
R / Rfree (%) 20.8 / 23.3

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Structure of An Acid-Sensing Ion Channel 1 at 1.9 A Resolution and Low pH (pdb code 2qts). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 6 binding sites of Chlorine where determined in the Structure of An Acid-Sensing Ion Channel 1 at 1.9 A Resolution and Low pH, PDB code: 2qts:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5; 6;

Chlorine binding site 1 out of 6 in 2qts

Go back to Chlorine Binding Sites List in 2qts
Chlorine binding site 1 out of 6 in the Structure of An Acid-Sensing Ion Channel 1 at 1.9 A Resolution and Low pH


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Structure of An Acid-Sensing Ion Channel 1 at 1.9 A Resolution and Low pH within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl464

b:26.9
occ:1.00
 OE2 A:GLU314 3.1 22.2 1.0
NZ C:LYS212 3.3 23.5 1.0
NE A:ARG310 3.3 18.9 1.0
NH1 A:ARG310 3.4 18.2 1.0
CG A:GLU314 3.7 20.9 1.0
CZ A:ARG310 3.8 19.5 1.0
CD A:GLU314 3.8 23.8 1.0
CD C:LYS212 3.9 22.2 1.0
O A:LEU352 3.9 19.7 1.0
CB A:CYS360 4.0 35.0 1.0
CE C:LYS212 4.1 24.2 1.0
CB A:LEU352 4.1 21.0 1.0
C A:LEU352 4.2 19.2 1.0
CB A:ARG310 4.3 21.0 1.0
CG A:ARG310 4.4 22.8 1.0
CD A:ARG310 4.4 20.1 1.0
O A:CYS360 4.4 37.7 1.0
CG1 A:VAL353 4.5 16.7 1.0
N A:VAL353 4.6 19.6 1.0
O A:ARG310 4.7 22.1 1.0
CA A:VAL353 4.8 17.1 1.0
CA A:LEU352 4.8 19.6 1.0
CA A:ARG310 4.8 22.3 1.0
SG A:CYS360 4.9 36.9 1.0
CD1 A:LEU352 5.0 22.1 1.0

Chlorine binding site 2 out of 6 in 2qts

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Chlorine binding site 2 out of 6 in the Structure of An Acid-Sensing Ion Channel 1 at 1.9 A Resolution and Low pH


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Structure of An Acid-Sensing Ion Channel 1 at 1.9 A Resolution and Low pH within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl464

b:29.4
occ:1.00
 OE2 B:GLU314 3.0 29.8 1.0
NE B:ARG310 3.3 24.5 1.0
NZ A:LYS212 3.3 22.4 1.0
NH1 B:ARG310 3.4 22.4 1.0
CG B:GLU314 3.7 28.4 1.0
CZ B:ARG310 3.8 24.8 1.0
CD B:GLU314 3.8 30.6 1.0
CD A:LYS212 3.9 24.0 1.0
O B:LEU352 4.0 23.9 1.0
CE A:LYS212 4.1 24.1 1.0
CB B:CYS360 4.2 48.1 1.0
CB B:LEU352 4.2 23.9 1.0
C B:LEU352 4.3 22.8 1.0
CB B:ARG310 4.3 25.6 1.0
CG1 B:VAL353 4.4 20.6 1.0
CD B:ARG310 4.4 24.8 1.0
CG B:ARG310 4.4 27.3 1.0
N B:VAL353 4.6 21.9 1.0
O B:ARG310 4.7 25.9 1.0
CA B:VAL353 4.7 21.8 1.0
SG B:CYS360 4.8 52.1 1.0
CA B:ARG310 4.8 26.5 1.0
CA B:LEU352 4.8 22.9 1.0
O B:CYS360 5.0 48.3 1.0

Chlorine binding site 3 out of 6 in 2qts

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Chlorine binding site 3 out of 6 in the Structure of An Acid-Sensing Ion Channel 1 at 1.9 A Resolution and Low pH


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Structure of An Acid-Sensing Ion Channel 1 at 1.9 A Resolution and Low pH within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Cl464

b:24.2
occ:1.00
 OE2 C:GLU314 3.0 21.9 1.0
NZ B:LYS212 3.3 18.8 1.0
NE C:ARG310 3.3 18.0 1.0
NH1 C:ARG310 3.4 17.5 1.0
CG C:GLU314 3.7 20.8 1.0
CZ C:ARG310 3.8 18.2 1.0
CD C:GLU314 3.8 23.8 1.0
O C:LEU352 3.9 18.1 1.0
CD B:LYS212 4.0 19.8 1.0
CB C:CYS360 4.1 34.9 1.0
CB C:LEU352 4.1 19.4 1.0
C C:LEU352 4.2 17.3 1.0
CE B:LYS212 4.2 18.5 1.0
CB C:ARG310 4.3 17.0 1.0
CG1 C:VAL353 4.4 15.8 1.0
CD C:ARG310 4.4 18.8 1.0
CG C:ARG310 4.4 17.5 1.0
N C:VAL353 4.6 17.2 1.0
O C:CYS360 4.6 38.0 1.0
O C:ARG310 4.6 19.6 1.0
CA C:VAL353 4.7 16.6 1.0
CA C:LEU352 4.8 17.4 1.0
CA C:ARG310 4.8 20.7 1.0
SG C:CYS360 4.9 37.4 1.0

Chlorine binding site 4 out of 6 in 2qts

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Chlorine binding site 4 out of 6 in the Structure of An Acid-Sensing Ion Channel 1 at 1.9 A Resolution and Low pH


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Structure of An Acid-Sensing Ion Channel 1 at 1.9 A Resolution and Low pH within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Cl4

b:31.2
occ:1.00
 OE2 D:GLU314 3.0 25.4 1.0
NE D:ARG310 3.2 22.8 1.0
NH1 D:ARG310 3.3 19.3 1.0
NZ F:LYS212 3.4 23.0 1.0
CG D:GLU314 3.7 25.0 1.0
CZ D:ARG310 3.7 22.4 1.0
CD D:GLU314 3.8 27.4 1.0
O D:LEU352 3.9 19.9 1.0
CD F:LYS212 4.0 23.6 1.0
CB D:CYS360 4.1 44.7 1.0
CB D:LEU352 4.1 20.6 1.0
CE F:LYS212 4.2 23.0 1.0
C D:LEU352 4.2 19.4 1.0
CB D:ARG310 4.4 23.0 1.0
CG1 D:VAL353 4.4 20.8 1.0
CD D:ARG310 4.4 23.9 1.0
CG D:ARG310 4.4 25.7 1.0
O D:ARG310 4.6 25.9 1.0
SG D:CYS360 4.6 47.9 1.0
N D:VAL353 4.6 19.7 1.0
CA D:VAL353 4.8 18.6 1.0
CA D:LEU352 4.8 20.0 1.0
CA D:ARG310 4.9 25.7 1.0
O D:CYS360 4.9 47.2 1.0

Chlorine binding site 5 out of 6 in 2qts

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Chlorine binding site 5 out of 6 in the Structure of An Acid-Sensing Ion Channel 1 at 1.9 A Resolution and Low pH


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 5 of Structure of An Acid-Sensing Ion Channel 1 at 1.9 A Resolution and Low pH within 5.0Å range:
probe atom residue distance (Å) B Occ
E:Cl5

b:31.7
occ:1.00
 OE2 E:GLU314 3.0 27.7 1.0
NH1 E:ARG310 3.3 19.5 1.0
NE E:ARG310 3.4 22.4 1.0
NZ D:LYS212 3.4 28.3 1.0
CG E:GLU314 3.7 25.2 1.0
CD E:GLU314 3.8 25.9 1.0
CZ E:ARG310 3.8 24.7 1.0
CD D:LYS212 4.0 28.4 1.0
O E:LEU352 4.0 23.1 1.0
CB E:CYS360 4.2 50.6 1.0
CB E:LEU352 4.2 24.7 1.0
C E:LEU352 4.2 23.7 1.0
CE D:LYS212 4.3 28.9 1.0
CB E:ARG310 4.4 23.6 1.0
CD E:ARG310 4.5 23.2 1.0
CG E:ARG310 4.6 24.2 1.0
CG1 E:VAL353 4.6 21.1 1.0
N E:VAL353 4.6 22.9 1.0
O E:ARG310 4.7 24.2 1.0
CA E:VAL353 4.7 21.4 1.0
SG E:CYS360 4.7 53.3 1.0
CA E:LEU352 4.8 22.9 1.0
CA E:ARG310 4.9 24.8 1.0
O E:CYS360 5.0 52.8 1.0
OE1 E:GLU314 5.0 25.9 1.0

Chlorine binding site 6 out of 6 in 2qts

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Chlorine binding site 6 out of 6 in the Structure of An Acid-Sensing Ion Channel 1 at 1.9 A Resolution and Low pH


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 6 of Structure of An Acid-Sensing Ion Channel 1 at 1.9 A Resolution and Low pH within 5.0Å range:
probe atom residue distance (Å) B Occ
F:Cl6

b:28.9
occ:1.00
 OE2 F:GLU314 3.1 26.3 1.0
NE F:ARG310 3.3 22.3 1.0
NZ E:LYS212 3.3 24.6 1.0
NH1 F:ARG310 3.4 21.4 1.0
CG F:GLU314 3.7 25.5 1.0
CD F:GLU314 3.8 27.5 1.0
CZ F:ARG310 3.8 21.3 1.0
O F:LEU352 3.9 21.1 1.0
CD E:LYS212 3.9 22.7 1.0
CB F:LEU352 4.1 23.8 1.0
CB F:CYS360 4.1 38.5 1.0
CE E:LYS212 4.1 22.4 1.0
C F:LEU352 4.2 22.8 1.0
CB F:ARG310 4.2 24.0 1.0
CG F:ARG310 4.4 23.6 1.0
CD F:ARG310 4.4 22.5 1.0
CG1 F:VAL353 4.4 20.8 1.0
O F:CYS360 4.4 41.0 1.0
N F:VAL353 4.6 21.5 1.0
O F:ARG310 4.6 22.2 1.0
CA F:VAL353 4.7 20.4 1.0
CA F:LEU352 4.7 22.7 1.0
CA F:ARG310 4.8 23.6 1.0
SG F:CYS360 5.0 39.5 1.0

Reference:

J.Jasti, H.Furukawa, E.B.Gonzales, E.Gouaux. Structure of Acid-Sensing Ion Channel 1 at 1.9A Resolution and Low pH Nature V. 449 316 2007.
ISSN: ISSN 0028-0836
PubMed: 17882215
DOI: 10.1038/NATURE06163
Page generated: Sat Jul 20 10:55:34 2024

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