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Chlorine in PDB 2quj: Crystal Structures of Human Tryptophanyl-Trna Synthetase in Complex with Trpamp

Enzymatic activity of Crystal Structures of Human Tryptophanyl-Trna Synthetase in Complex with Trpamp

All present enzymatic activity of Crystal Structures of Human Tryptophanyl-Trna Synthetase in Complex with Trpamp:
6.1.1.2;

Protein crystallography data

The structure of Crystal Structures of Human Tryptophanyl-Trna Synthetase in Complex with Trpamp, PDB code: 2quj was solved by N.Shen, J.P.Ding, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 50.00 / 2.42
Space group P 43 21 2
Cell size a, b, c (Å), α, β, γ (°) 80.000, 80.000, 383.000, 90.00, 90.00, 90.00
R / Rfree (%) 21.4 / 23.8

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Crystal Structures of Human Tryptophanyl-Trna Synthetase in Complex with Trpamp (pdb code 2quj). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 9 binding sites of Chlorine where determined in the Crystal Structures of Human Tryptophanyl-Trna Synthetase in Complex with Trpamp, PDB code: 2quj:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9;

Chlorine binding site 1 out of 9 in 2quj

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Chlorine binding site 1 out of 9 in the Crystal Structures of Human Tryptophanyl-Trna Synthetase in Complex with Trpamp


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structures of Human Tryptophanyl-Trna Synthetase in Complex with Trpamp within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl802

b:89.1
occ:1.00
 O A:HOH910 2.8 57.0 1.0
N A:HIS474 3.6 79.2 1.0
O A:HIS474 3.6 85.4 1.0
CA A:HIS473 3.7 73.2 1.0
CD2 A:HIS473 3.8 63.8 1.0
CB A:HIS473 4.1 68.4 1.0
C A:HIS473 4.2 75.9 1.0
CG A:HIS473 4.3 65.3 1.0
C A:HIS474 4.4 85.7 1.0
O A:HIS472 4.4 74.1 1.0
CA A:HIS474 4.6 83.6 1.0
N A:HIS473 4.8 73.0 1.0
ND1 A:HIS474 5.0 87.7 1.0

Chlorine binding site 2 out of 9 in 2quj

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Chlorine binding site 2 out of 9 in the Crystal Structures of Human Tryptophanyl-Trna Synthetase in Complex with Trpamp


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structures of Human Tryptophanyl-Trna Synthetase in Complex with Trpamp within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl804

b:88.9
occ:1.00
 O A:HOH907 3.3 61.2 1.0
CB A:PHE138 3.7 36.1 1.0
NZ A:LYS111 3.8 65.6 1.0
OD1 A:ASP101 3.9 71.8 1.0
O A:GLY135 3.9 39.5 1.0
CG A:PHE138 4.1 32.6 1.0
CB A:TYR100 4.4 56.6 1.0
CD2 A:PHE138 4.4 30.9 1.0
C A:GLY135 4.8 40.7 1.0
CA A:GLY135 4.9 39.6 1.0
CD1 A:PHE138 4.9 34.0 1.0
CD1 A:TYR100 5.0 55.2 1.0
CE A:LYS111 5.0 64.4 1.0

Chlorine binding site 3 out of 9 in 2quj

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Chlorine binding site 3 out of 9 in the Crystal Structures of Human Tryptophanyl-Trna Synthetase in Complex with Trpamp


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Crystal Structures of Human Tryptophanyl-Trna Synthetase in Complex with Trpamp within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl805

b:78.0
occ:1.00
 NZ A:LYS204 3.4 65.8 1.0
N A:ASP205 3.6 57.9 1.0
CG A:LYS204 3.9 59.9 1.0
CB A:LYS204 4.0 57.8 1.0
CB A:ASP205 4.1 61.5 1.0
CA A:LYS204 4.1 56.1 1.0
CD A:LYS204 4.4 62.9 1.0
C A:LYS204 4.4 56.7 1.0
CA A:ASP205 4.5 59.0 1.0
CE A:LYS204 4.5 64.0 1.0

Chlorine binding site 4 out of 9 in 2quj

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Chlorine binding site 4 out of 9 in the Crystal Structures of Human Tryptophanyl-Trna Synthetase in Complex with Trpamp


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Crystal Structures of Human Tryptophanyl-Trna Synthetase in Complex with Trpamp within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl807

b:73.4
occ:1.00
 NH2 A:ARG388 3.4 56.8 1.0
NE A:ARG388 3.7 53.9 1.0
CD1 A:ILE384 3.8 60.7 1.0
CZ A:ARG388 4.0 56.0 1.0
CG1 A:ILE384 4.6 59.1 1.0
CD A:ARG388 4.8 51.6 1.0
CG A:ARG388 4.9 51.0 1.0

Chlorine binding site 5 out of 9 in 2quj

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Chlorine binding site 5 out of 9 in the Crystal Structures of Human Tryptophanyl-Trna Synthetase in Complex with Trpamp


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 5 of Crystal Structures of Human Tryptophanyl-Trna Synthetase in Complex with Trpamp within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl809

b:70.3
occ:1.00
 CB A:ASP113 3.5 52.1 1.0
N A:LYS114 3.7 53.5 1.0
CA A:ASP113 4.1 51.3 1.0
CB A:LYS114 4.3 58.2 1.0
CG A:LYS114 4.3 61.5 1.0
C A:ASP113 4.5 52.2 1.0
CA A:LYS114 4.6 55.1 1.0
CG A:ASP113 4.7 54.1 1.0

Chlorine binding site 6 out of 9 in 2quj

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Chlorine binding site 6 out of 9 in the Crystal Structures of Human Tryptophanyl-Trna Synthetase in Complex with Trpamp


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 6 of Crystal Structures of Human Tryptophanyl-Trna Synthetase in Complex with Trpamp within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl801

b:84.7
occ:1.00
 O3 B:GOL812 2.8 62.5 1.0
OH B:TYR201 3.2 42.6 1.0
NE2 A:HIS257 3.8 49.4 1.0
CZ B:TYR201 4.2 40.7 1.0
CE A:LYS253 4.2 49.3 1.0
CE1 B:TYR201 4.3 40.6 1.0
C3 B:GOL812 4.3 62.4 1.0
CE1 A:HIS257 4.4 47.5 1.0
CG2 A:ILE327 4.6 38.4 1.0
CD2 A:HIS257 4.9 46.7 1.0
CB A:ILE327 4.9 40.8 1.0
CA A:ILE327 4.9 41.5 1.0

Chlorine binding site 7 out of 9 in 2quj

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Chlorine binding site 7 out of 9 in the Crystal Structures of Human Tryptophanyl-Trna Synthetase in Complex with Trpamp


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 7 of Crystal Structures of Human Tryptophanyl-Trna Synthetase in Complex with Trpamp within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl803

b:82.1
occ:1.00
 NH2 B:ARG122 3.5 66.0 1.0
ND2 B:ASN118 3.7 54.5 1.0
CB B:ASN118 4.1 50.7 1.0
CG B:ASN118 4.4 52.5 1.0
CA B:GLU115 4.6 50.7 1.0
CZ B:ARG122 4.7 66.8 1.0
CG B:GLU115 4.8 58.9 1.0
O B:GLU115 4.9 48.4 1.0

Chlorine binding site 8 out of 9 in 2quj

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Chlorine binding site 8 out of 9 in the Crystal Structures of Human Tryptophanyl-Trna Synthetase in Complex with Trpamp


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 8 of Crystal Structures of Human Tryptophanyl-Trna Synthetase in Complex with Trpamp within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl806

b:66.6
occ:1.00
 N B:ASP205 3.8 49.3 1.0
CA B:LYS204 4.0 46.0 1.0
NZ B:LYS204 4.1 59.4 1.0
CB B:LYS204 4.1 47.5 1.0
CE B:LYS204 4.4 54.4 1.0
C B:LYS204 4.4 47.4 1.0
CG B:LYS204 4.5 49.9 1.0
CB B:ASP205 4.6 54.2 1.0
CA B:ASP205 4.8 50.0 1.0
O B:TRP203 4.9 43.6 1.0

Chlorine binding site 9 out of 9 in 2quj

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Chlorine binding site 9 out of 9 in the Crystal Structures of Human Tryptophanyl-Trna Synthetase in Complex with Trpamp


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 9 of Crystal Structures of Human Tryptophanyl-Trna Synthetase in Complex with Trpamp within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl808

b:83.4
occ:1.00
 CG B:LYS114 3.3 59.0 1.0
CE B:LYS114 3.4 66.2 1.0
N B:LYS114 3.5 51.0 1.0
CD B:LYS114 3.6 63.4 1.0
CB B:ASP113 3.7 52.5 1.0
CA B:ASP113 4.0 50.9 1.0
CB B:LYS114 4.1 54.0 1.0
C B:ASP113 4.2 52.0 1.0
NZ B:LYS114 4.3 69.0 1.0
CA B:LYS114 4.4 52.4 1.0

Reference:

N.Shen, M.Zhou, B.Yang, Y.Yu, X.Dong, J.Ding. Catalytic Mechanism of the Tryptophan Activation Reaction Revealed By Crystal Structures of Human Tryptophanyl-Trna Synthetase in Different Enzymatic States Nucleic Acids Res. V. 36 1288 2008.
ISSN: ISSN 0305-1048
PubMed: 18180246
DOI: 10.1093/NAR/GKM1153
Page generated: Sat Dec 12 09:17:49 2020

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