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Chlorine in PDB 2rl5: Crystal Structure of the VEGFR2 Kinase Domain in Complex with A 2,3- Dihydro-1,4-Benzoxazine Inhibitor
Enzymatic activity of Crystal Structure of the VEGFR2 Kinase Domain in Complex with A 2,3- Dihydro-1,4-Benzoxazine Inhibitor
All present enzymatic activity of Crystal Structure of the VEGFR2 Kinase Domain in Complex with A 2,3- Dihydro-1,4-Benzoxazine Inhibitor:
2.7.10.1;
2.7.10.1;
Protein crystallography data
The structure of Crystal Structure of the VEGFR2 Kinase Domain in Complex with A 2,3- Dihydro-1,4-Benzoxazine Inhibitor, PDB code: 2rl5
was solved by
D.A.Whittington,
A.M.Long,
P.Rose,
H.Zhao,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 30.00 / 2.65 |
| Space group | P 21 21 2 |
| Cell size a, b, c (Å), α, β, γ (°) | 66.760, 139.774, 57.550, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 19.9 / 23.3 |
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Crystal Structure of the VEGFR2 Kinase Domain in Complex with A 2,3- Dihydro-1,4-Benzoxazine Inhibitor
(pdb code 2rl5). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Crystal Structure of the VEGFR2 Kinase Domain in Complex with A 2,3- Dihydro-1,4-Benzoxazine Inhibitor, PDB code: 2rl5:
In total only one binding site of Chlorine was determined in the Crystal Structure of the VEGFR2 Kinase Domain in Complex with A 2,3- Dihydro-1,4-Benzoxazine Inhibitor, PDB code: 2rl5:
Chlorine binding site 1 out of 1 in 2rl5
Go back to
Chlorine Binding Sites List in 2rl5
Chlorine binding site 1 out
of 1 in the Crystal Structure of the VEGFR2 Kinase Domain in Complex with A 2,3- Dihydro-1,4-Benzoxazine Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Chlorine with other atoms in the Cl binding
site number 1 of Crystal Structure of the VEGFR2 Kinase Domain in Complex with A 2,3- Dihydro-1,4-Benzoxazine Inhibitor within 5.0Å range:
|
Reference:
D.S.La,
J.Belzile,
J.V.Bready,
A.Coxon,
T.Demelfi,
N.Doerr,
J.Estrada,
J.C.Flynn,
S.R.Flynn,
R.F.Graceffa,
S.P.Harriman,
J.F.Larrow,
A.M.Long,
M.W.Martin,
M.J.Morrison,
V.F.Patel,
P.M.Roveto,
L.Wang,
M.M.Weiss,
D.A.Whittington,
Y.Teffera,
Z.Zhao,
A.J.Polverino,
J.C.Harmange.
Novel 2,3-Dihydro-1,4-Benzoxazines As Potent and Orally Bioavailable Inhibitors of Tumor-Driven Angiogenesis. J.Med.Chem. V. 51 1695 2008.
ISSN: ISSN 0022-2623
PubMed: 18311900
DOI: 10.1021/JM701129J
Page generated: Sat Jul 20 11:21:43 2024
ISSN: ISSN 0022-2623
PubMed: 18311900
DOI: 10.1021/JM701129J
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