Chlorine in PDB 2uwn: Crystal Structure of Human Complement Factor H, Scr Domains 6-8 (H402 Risk Variant), in Complex with Ligand.

The structure of Crystal Structure of Human Complement Factor H, Scr Domains 6-8 (H402 Risk Variant), in Complex with Ligand., PDB code: 2uwn was solved by B.E.Prosser, S.Johnson, P.Roversi, A.P.Herbert, B.S.Blaum, J.Tyrrell, T.A.Jowitt, S.J.Clark, E.Terelli, D.Uhrin, P.N.Barlow, R.B.Sim, A.J.Day, S.M.Lea, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	15.0 / 2.35
Space group	C 2 2 21
Cell size a, b, c (Å), α, β, γ (°)	74.756, 92.491, 57.311, 90.00, 90.00, 90.00
R / Rfree (%)	21.4 / 24.6

The binding sites of Chlorine atom in the Crystal Structure of Human Complement Factor H, Scr Domains 6-8 (H402 Risk Variant), in Complex with Ligand. (pdb code 2uwn). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Crystal Structure of Human Complement Factor H, Scr Domains 6-8 (H402 Risk Variant), in Complex with Ligand., PDB code: 2uwn:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Crystal Structure of Human Complement Factor H, Scr Domains 6-8 (H402 Risk Variant), in Complex with Ligand.


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Human Complement Factor H, Scr Domains 6-8 (H402 Risk Variant), in Complex with Ligand. within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1510 b:40.5 occ:1.00 N A:CYS442 3.0 24.2 1.0 N A:ASN396 3.3 19.2 1.0 N A:GLU395 3.5 22.4 1.0 O A:HOH2037 3.6 43.6 1.0 CB A:CYS442 3.6 22.7 1.0 CA A:LEU394 3.7 23.0 1.0 C A:LEU394 3.8 26.2 1.0 CA A:CYS442 3.8 23.5 1.0 O A:CYS442 3.9 28.6 1.0 CA A:ARG441 3.9 24.0 1.0 CB A:LEU394 3.9 23.0 1.0 C A:ARG441 3.9 27.4 1.0 CA A:ASN396 4.0 17.5 1.0 CB A:ASN396 4.0 16.1 1.0 SG A:CYS442 4.1 26.0 1.0 O A:HOH2038 4.1 60.9 1.0 CG A:GLU395 4.1 38.1 1.0 C A:ASN396 4.2 18.8 1.0 C A:GLU395 4.3 24.6 1.0 CD2 A:LEU394 4.3 28.9 1.0 CB A:ARG441 4.3 25.0 1.0 C A:CYS442 4.3 28.8 1.0 CA A:GLU395 4.3 22.0 1.0 N A:GLY397 4.4 15.1 1.0 O A:LEU394 4.7 26.1 1.0 O A:ASN396 4.7 17.7 1.0 CG A:LEU394 4.8 27.6 1.0 OD1 A:ASN396 4.8 22.7 1.0 CB A:GLU395 4.8 23.6 1.0 CG A:ASN396 4.8 26.2 1.0

Chlorine binding site 2 out of 2 in the Crystal Structure of Human Complement Factor H, Scr Domains 6-8 (H402 Risk Variant), in Complex with Ligand.


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of Human Complement Factor H, Scr Domains 6-8 (H402 Risk Variant), in Complex with Ligand. within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1511 b:58.6 occ:1.00 O A:GLY458 2.8 24.3 1.0 O A:ILE455 2.9 26.2 1.0 CG2 A:ILE455 3.3 28.4 1.0 CA A:PHE459 3.8 22.7 1.0 C A:GLY458 3.9 25.6 1.0 C A:ILE455 4.0 28.4 1.0 CB A:PHE459 4.2 24.0 1.0 N A:PHE459 4.3 22.9 1.0 CB A:ILE455 4.4 28.0 1.0 CA A:ILE455 4.5 24.4 1.0 N A:ILE455 4.6 24.8 1.0 CG1 A:ILE455 4.9 28.6 1.0 C A:PHE459 4.9 29.2 1.0 N A:ILE460 5.0 28.2 1.0

B.E.Prosser, S.Johnson, P.Roversi, A.P.Herbert, B.S.Blaum, J.Tyrrell, T.A.Jowitt, S.J.Clark, E.Tarelli, D.Uhrin, P.N.Barlow, R.B.Sim, A.J.Day, S.M.Lea. Structural Basis For Complement Factor H Linked Age-Related Macular Degeneration. J.Exp.Med. V. 204 2277 2007.
ISSN: ISSN 0022-1007
PubMed: 17893204
DOI: 10.1084/JEM.20071069