Chlorine in PDB 2uxx: Human LSD1 Histone Demethylase-Corest in Complex with An Fad- Tranylcypromine Adduct

The structure of Human LSD1 Histone Demethylase-Corest in Complex with An Fad- Tranylcypromine Adduct, PDB code: 2uxx was solved by M.Yang, J.C.Culhane, M.Machius, P.A.Cole, H.Yu, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	49.00 / 2.74
Space group	I 2 2 2
Cell size a, b, c (Å), α, β, γ (°)	120.798, 178.500, 235.880, 90.00, 90.00, 90.00
R / Rfree (%)	23.5 / 26

The binding sites of Chlorine atom in the Human LSD1 Histone Demethylase-Corest in Complex with An Fad- Tranylcypromine Adduct (pdb code 2uxx). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Human LSD1 Histone Demethylase-Corest in Complex with An Fad- Tranylcypromine Adduct, PDB code: 2uxx:

Chlorine binding site 1 out of 1 in the Human LSD1 Histone Demethylase-Corest in Complex with An Fad- Tranylcypromine Adduct


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Human LSD1 Histone Demethylase-Corest in Complex with An Fad- Tranylcypromine Adduct within 5.0Å range:

M.Yang, J.C.Culhane, L.M.Szewczuk, P.Jalili, H.L.Ball, M.Machius, P.A.Cole, H.Yu. Structural Basis For the Inhibition of the LSD1 Histone Demethylase By the Antidepressant Trans-2-Phenylcyclopropylamine. Biochemistry V. 46 8058 2007.
ISSN: ISSN 0006-2960
PubMed: 17569509
DOI: 10.1021/BI700664Y