Chlorine in PDB 2v8e: Crystal Structure of Human Complement Factor H, Scr Domains 6-8 (H402 Risk Variant), in Complex with Ligand.

The structure of Crystal Structure of Human Complement Factor H, Scr Domains 6-8 (H402 Risk Variant), in Complex with Ligand., PDB code: 2v8e was solved by B.E.Prosser, S.Johnson, P.Roversi, A.P.Herbert, B.S.Blaum, J.Tyrrell, T.A.Jowitt, S.J.Clark, E.Tarelli, D.Uhrin, P.N.Barlow, R.B.Sim, A.J.Day, S.M.Lea, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	15.0 / 2.50
Space group	C 2 2 21
Cell size a, b, c (Å), α, β, γ (°)	75.000, 92.500, 57.100, 90.00, 90.00, 90.00
R / Rfree (%)	n/a / 22.55

The binding sites of Chlorine atom in the Crystal Structure of Human Complement Factor H, Scr Domains 6-8 (H402 Risk Variant), in Complex with Ligand. (pdb code 2v8e). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Crystal Structure of Human Complement Factor H, Scr Domains 6-8 (H402 Risk Variant), in Complex with Ligand., PDB code: 2v8e:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Crystal Structure of Human Complement Factor H, Scr Domains 6-8 (H402 Risk Variant), in Complex with Ligand.


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Crystal Structure of Human Complement Factor H, Scr Domains 6-8 (H402 Risk Variant), in Complex with Ligand. within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1508 b:42.7 occ:1.00 N A:CYS442 3.0 33.4 1.0 N A:GLU395 3.6 28.0 1.0 N A:ASN396 3.6 27.8 1.0 CA A:ARG441 3.7 30.5 1.0 O A:CYS442 3.8 34.2 1.0 C A:ARG441 3.8 36.5 1.0 CA A:CYS442 3.9 30.4 1.0 CA A:LEU394 3.9 25.0 1.0 CB A:ARG441 3.9 32.7 1.0 CB A:CYS442 3.9 28.4 1.0 CG A:GLU395 4.0 39.4 1.0 C A:LEU394 4.0 29.3 1.0 CB A:LEU394 4.2 23.6 1.0 C A:CYS442 4.2 34.7 1.0 CB A:ASN396 4.3 29.0 1.0 CA A:ASN396 4.4 27.4 1.0 CA A:GLU395 4.4 27.8 1.0 OD1 A:ASN396 4.4 28.4 1.0 CD2 A:LEU394 4.5 16.6 1.0 C A:GLU395 4.5 32.1 1.0 SG A:CYS442 4.6 30.8 1.0 C A:ASN396 4.7 25.8 1.0 CG A:ASN396 4.7 35.3 1.0 CB A:GLU395 4.8 28.9 1.0 N A:GLY397 4.9 20.9 1.0 O A:TYR393 4.9 35.2 1.0 O A:LEU394 5.0 30.4 1.0 O A:ARG441 5.0 36.4 1.0

Chlorine binding site 2 out of 2 in the Crystal Structure of Human Complement Factor H, Scr Domains 6-8 (H402 Risk Variant), in Complex with Ligand.


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Crystal Structure of Human Complement Factor H, Scr Domains 6-8 (H402 Risk Variant), in Complex with Ligand. within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1509 b:55.1 occ:1.00 O A:GLY458 2.8 23.9 1.0 O A:ILE455 2.9 31.1 1.0 CG2 A:ILE455 3.4 30.5 1.0 CA A:PHE459 3.8 22.7 1.0 C A:GLY458 3.9 25.6 1.0 C A:ILE455 4.0 33.2 1.0 N A:PHE459 4.3 23.1 1.0 CB A:PHE459 4.3 23.6 1.0 CB A:ILE455 4.5 31.7 1.0 CA A:ILE455 4.5 28.7 1.0 N A:ILE455 4.5 29.0 1.0 C A:PHE459 4.8 28.3 1.0 N A:ILE460 4.9 28.8 1.0 CG1 A:ILE455 4.9 32.8 1.0

B.E.Prosser, S.Johnson, P.Roversi, A.P.Herbert, B.S.Blaum, J.Tyrrell, T.A.Jowitt, S.J.Clark, E.Tarelli, D.Uhrin, P.N.Barlow, R.B.Sim, A.J.Day, S.M.Lea. Structural Basis For Complement Factor H Linked Age-Related Macular Degeneration. J.Exp.Med. V. 204 2277 2007.
ISSN: ISSN 0022-1007
PubMed: 17893204
DOI: 10.1084/JEM.20071069