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Atomistry » Chlorine » PDB 2vfx-2vo3 » 2vio | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Chlorine » PDB 2vfx-2vo3 » 2vio » |
Chlorine in PDB 2vio: Fragment-Based Discovery of Mexiletine Derivatives As Orally Bioavailable Inhibitors of Urokinase-Type Plasminogen ActivatorEnzymatic activity of Fragment-Based Discovery of Mexiletine Derivatives As Orally Bioavailable Inhibitors of Urokinase-Type Plasminogen Activator
All present enzymatic activity of Fragment-Based Discovery of Mexiletine Derivatives As Orally Bioavailable Inhibitors of Urokinase-Type Plasminogen Activator:
3.4.21.73; Protein crystallography data
The structure of Fragment-Based Discovery of Mexiletine Derivatives As Orally Bioavailable Inhibitors of Urokinase-Type Plasminogen Activator, PDB code: 2vio
was solved by
M.Frederickson,
O.Callaghan,
G.Chessari,
M.Congreve,
S.R.Cowan,
J.E.Matthews,
R.Mcmenamin,
D.Smith,
M.Vinkovic,
N.G.Wallis,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Chlorine Binding Sites:
The binding sites of Chlorine atom in the Fragment-Based Discovery of Mexiletine Derivatives As Orally Bioavailable Inhibitors of Urokinase-Type Plasminogen Activator
(pdb code 2vio). This binding sites where shown within
5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Fragment-Based Discovery of Mexiletine Derivatives As Orally Bioavailable Inhibitors of Urokinase-Type Plasminogen Activator, PDB code: 2vio: Jump to Chlorine binding site number: 1; 2; Chlorine binding site 1 out of 2 in 2vioGo back to Chlorine Binding Sites List in 2vio
Chlorine binding site 1 out
of 2 in the Fragment-Based Discovery of Mexiletine Derivatives As Orally Bioavailable Inhibitors of Urokinase-Type Plasminogen Activator
Mono view Stereo pair view
Chlorine binding site 2 out of 2 in 2vioGo back to Chlorine Binding Sites List in 2vio
Chlorine binding site 2 out
of 2 in the Fragment-Based Discovery of Mexiletine Derivatives As Orally Bioavailable Inhibitors of Urokinase-Type Plasminogen Activator
Mono view Stereo pair view
Reference:
M.Frederickson,
O.Callaghan,
G.Chessari,
M.Congreve,
S.R.Cowan,
J.E.Matthews,
R.Mcmenamin,
D.Smith,
M.Vinkovic,
N.G.Wallis.
Fragment-Based Discovery of Mexiletine Derivatives As Orally Bioavailable Inhibitors of Urokinase-Type Plasminogen Activator J.Med.Chem. V. 51 183 2008.
Page generated: Sat Dec 12 09:20:38 2020
ISSN: ISSN 0022-2623 PubMed: 18163548 DOI: 10.1021/JM701359Z |
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