Chlorine in PDB 2vj3: Human Notch-1 Egfs 11-13

The structure of Human Notch-1 Egfs 11-13, PDB code: 2vj3 was solved by S.Johnson, J.Cordle, J.Z.Tay, P.Roversi, S.M.Lea, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	95.40 / 2.60
Space group	P 31 2 1
Cell size a, b, c (Å), α, β, γ (°)	28.000, 28.000, 281.700, 90.00, 90.00, 120.00
R / Rfree (%)	23.9 / 24.4

The structure of Human Notch-1 Egfs 11-13 also contains other interesting chemical elements:

Calcium	(Ca)	4 atoms
Sodium	(Na)	2 atoms

The binding sites of Chlorine atom in the Human Notch-1 Egfs 11-13 (pdb code 2vj3). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Human Notch-1 Egfs 11-13, PDB code: 2vj3:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Human Notch-1 Egfs 11-13


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Human Notch-1 Egfs 11-13 within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1537 b:65.1 occ:1.00 NA A:NA1535 2.8 44.4 1.0 N A:GLY522 3.9 36.6 1.0 N A:HIS523 4.0 34.6 1.0 O A:THR521 4.5 41.6 1.0 CG2 A:VAL527 4.5 37.2 1.0 CB A:HIS523 4.5 35.0 1.0 CG A:GLN526 4.6 39.6 1.0 N A:LEU524 4.6 32.8 1.0 C A:THR521 4.6 40.6 1.0 CA A:GLY522 4.7 37.0 1.0 CA A:HIS523 4.7 34.6 1.0 C A:GLY522 4.9 39.9 1.0 CD A:GLN526 4.9 55.9 1.0 OE1 A:GLN526 5.0 52.1 1.0

Chlorine binding site 2 out of 2 in the Human Notch-1 Egfs 11-13


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Human Notch-1 Egfs 11-13 within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1538 b:54.6 occ:1.00 O A:VAL485 2.8 29.0 1.0 N A:CYS476 2.8 22.7 1.0 O A:HOH2014 3.1 18.2 1.0 CA A:GLN475 3.5 20.7 1.0 C A:GLN475 3.6 25.3 1.0 CB A:CYS476 3.7 23.6 1.0 C A:VAL485 3.7 29.3 1.0 CA A:CYS476 3.7 23.3 1.0 CG1 A:VAL485 3.8 30.8 1.0 CA A:VAL485 3.9 28.0 1.0 O A:CYS476 4.0 26.1 1.0 SG A:CYS476 4.0 27.1 1.0 CB A:GLN475 4.2 22.6 1.0 O A:PHE474 4.3 23.3 1.0 C A:CYS476 4.3 27.3 1.0 CG A:GLN475 4.3 34.5 1.0 CB A:VAL485 4.5 31.4 1.0 N A:GLN475 4.6 21.5 1.0 CE2 A:PHE474 4.7 27.2 1.0 O A:GLN475 4.8 26.0 1.0 O A:GLY484 4.8 31.6 1.0 C A:PHE474 4.8 24.6 1.0 CD2 A:PHE474 4.9 24.9 1.0 N A:HIS486 4.9 24.1 1.0

J.Cordle, S.Johnson, J.Z.Tay, P.Roversi, M.B.Wilkin, B.H.De Madrid, H.Shimizu, S.Jensen, P.Whiteman, B.Jin, C.Redfield, M.Baron, S.M.Lea, P.A.Handford. A Conserved Face of the Jagged/Serrate Dsl Domain Is Involved in Notch Trans-Activation and Cis-Inhibition. Nat.Struct.Mol.Biol. V. 15 849 2008.
ISSN: ISSN 1545-9993
PubMed: 18660822
DOI: 10.1038/NSMB.1457