Chlorine in PDB 2vke: Tet Repressor Class D Complexed with Cobalt and Tetracycline

The structure of Tet Repressor Class D Complexed with Cobalt and Tetracycline, PDB code: 2vke was solved by G.J.Palm, W.Hinrichs, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	62.87 / 1.62
Space group	I 41 2 2
Cell size a, b, c (Å), α, β, γ (°)	67.014, 67.014, 180.806, 90.00, 90.00, 90.00
R / Rfree (%)	24.5 / 29.7

The structure of Tet Repressor Class D Complexed with Cobalt and Tetracycline also contains other interesting chemical elements:

Cobalt

(Co)

1 atom

The binding sites of Chlorine atom in the Tet Repressor Class D Complexed with Cobalt and Tetracycline (pdb code 2vke). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 3 binding sites of Chlorine where determined in the Tet Repressor Class D Complexed with Cobalt and Tetracycline, PDB code: 2vke:
Jump to Chlorine binding site number: 1; 2; 3;

Chlorine binding site 1 out of 3 in the Tet Repressor Class D Complexed with Cobalt and Tetracycline


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Tet Repressor Class D Complexed with Cobalt and Tetracycline within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1227 b:35.5 occ:1.00 N A:SER74 3.1 26.5 1.0 OG A:SER74 3.2 24.8 1.0 CB A:SER74 3.5 27.7 1.0 CB A:SER77 3.6 26.2 1.0 CA A:SER74 3.9 26.2 1.0 OG A:SER77 4.0 27.1 1.0 C A:GLU73 4.1 27.5 1.0 CA A:GLU73 4.1 29.4 1.0 CG A:GLU73 4.2 29.9 1.0 O A:GLY72 4.7 30.2 1.0 CB A:GLU73 4.7 28.2 1.0 O A:SER74 4.9 25.9 1.0 C A:SER74 4.9 27.5 1.0 CA A:SER77 5.0 27.1 1.0

Chlorine binding site 2 out of 3 in the Tet Repressor Class D Complexed with Cobalt and Tetracycline


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Tet Repressor Class D Complexed with Cobalt and Tetracycline within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1228 b:35.3 occ:1.00 N A:LEU4 3.0 24.2 1.0 NH1 A:ARG3 3.4 37.6 1.0 CA A:LEU4 3.7 24.0 1.0 CB A:LEU4 3.7 23.0 1.0 CD A:ARG3 3.9 30.7 1.0 C A:ARG3 4.0 24.5 1.0 CA A:ARG3 4.1 25.1 1.0 C A:LEU4 4.1 25.4 1.0 N A:ASN5 4.2 24.6 1.0 CG A:LEU4 4.3 22.4 1.0 CG A:ARG3 4.4 28.4 1.0 CZ A:ARG3 4.5 38.9 1.0 O A:SER2 4.6 25.5 1.0 NE A:ARG3 4.7 36.4 1.0 O A:LEU4 4.7 26.8 1.0 CB A:ARG3 4.8 26.1 1.0 CD1 A:LEU4 4.9 19.7 1.0

Chlorine binding site 3 out of 3 in the Tet Repressor Class D Complexed with Cobalt and Tetracycline


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Tet Repressor Class D Complexed with Cobalt and Tetracycline within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1229 b:41.5 occ:0.50 NE1 A:TRP75 3.1 28.6 1.0 O A:HOH2042 3.4 37.5 1.0 NE2 A:GLN76 3.5 31.2 1.0 CD2 A:LEU201 3.9 32.7 1.0 CE2 A:TRP75 4.0 27.6 1.0 CD1 A:TRP75 4.1 29.6 1.0 CZ2 A:TRP75 4.3 30.5 1.0 CD A:GLN76 4.3 29.2 1.0 OE1 A:GLN76 4.3 24.4 1.0 CG2 A:THR202 4.5 33.6 1.0 CG A:GLU198 4.6 31.8 1.0

G.J.Palm, T.Lederer, P.Orth, W.Saenger, M.Takahashi, W.Hillen, W.Hinrichs. Specific Binding of Divalent Metal Ions to Tetracycline and to the Tet Repressor/Tetracycline Complex. J.Biol.Inorg.Chem. V. 13 1097 2008.
ISSN: ISSN 0949-8257
PubMed: 18548290
DOI: 10.1007/S00775-008-0395-2