Atomistry » Chlorine » PDB 2vo6-2vv8 » 2vps
Atomistry »
  Chlorine »
    PDB 2vo6-2vv8 »
      2vps »

Chlorine in PDB 2vps: Structure of the Bifunctional Leishmania Major Trypanothione Synthetase-Amidase

Enzymatic activity of Structure of the Bifunctional Leishmania Major Trypanothione Synthetase-Amidase

All present enzymatic activity of Structure of the Bifunctional Leishmania Major Trypanothione Synthetase-Amidase:
6.3.1.9;

Protein crystallography data

The structure of Structure of the Bifunctional Leishmania Major Trypanothione Synthetase-Amidase, PDB code: 2vps was solved by P.K.Fyfe, S.L.Oza, A.H.Fairlamb, W.N.Hunter, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 28.33 / 2.75
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 71.050, 85.600, 168.340, 90.00, 90.00, 90.00
R / Rfree (%) 20.4 / 25

Other elements in 2vps:

The structure of Structure of the Bifunctional Leishmania Major Trypanothione Synthetase-Amidase also contains other interesting chemical elements:

Bromine (Br) 2 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Structure of the Bifunctional Leishmania Major Trypanothione Synthetase-Amidase (pdb code 2vps). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 5 binding sites of Chlorine where determined in the Structure of the Bifunctional Leishmania Major Trypanothione Synthetase-Amidase, PDB code: 2vps:
Jump to Chlorine binding site number: 1; 2; 3; 4; 5;

Chlorine binding site 1 out of 5 in 2vps

Go back to Chlorine Binding Sites List in 2vps
Chlorine binding site 1 out of 5 in the Structure of the Bifunctional Leishmania Major Trypanothione Synthetase-Amidase


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Structure of the Bifunctional Leishmania Major Trypanothione Synthetase-Amidase within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl1653

b:52.2
occ:1.00
 N A:ARG397 3.4 54.9 1.0
CA A:GLY396 3.7 55.1 1.0
CD A:ARG452 4.0 53.6 1.0
C A:GLY396 4.0 55.1 1.0
CB A:ARG397 4.1 55.1 1.0
CA A:ARG397 4.4 54.8 1.0
NE A:ARG452 4.4 54.1 1.0
CG1 A:VAL449 4.5 50.9 1.0
CG A:ARG452 4.8 52.5 1.0
N A:GLY396 5.0 55.4 1.0

Chlorine binding site 2 out of 5 in 2vps

Go back to Chlorine Binding Sites List in 2vps
Chlorine binding site 2 out of 5 in the Structure of the Bifunctional Leishmania Major Trypanothione Synthetase-Amidase


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Structure of the Bifunctional Leishmania Major Trypanothione Synthetase-Amidase within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl1654

b:80.5
occ:1.00
 NH2 A:ARG167 3.3 61.6 1.0
NH1 A:ARG167 3.9 60.5 1.0
CZ A:ARG167 4.1 60.7 1.0

Chlorine binding site 3 out of 5 in 2vps

Go back to Chlorine Binding Sites List in 2vps
Chlorine binding site 3 out of 5 in the Structure of the Bifunctional Leishmania Major Trypanothione Synthetase-Amidase


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 3 of Structure of the Bifunctional Leishmania Major Trypanothione Synthetase-Amidase within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl1655

b:47.5
occ:1.00
 N A:PHE55 3.4 57.4 1.0
OE1 A:GLN58 3.5 65.5 1.0
CB A:GLN58 3.6 58.9 1.0
O A:HOH2015 3.7 47.5 1.0
N A:GLU61 3.8 57.7 1.0
CB A:VAL60 4.0 57.2 1.0
CB A:PHE55 4.0 57.0 1.0
CA A:GLY54 4.1 58.4 1.0
CD2 A:PHE55 4.1 55.6 1.0
C A:GLY54 4.2 58.0 1.0
CA A:PHE55 4.2 57.1 1.0
CB A:GLU61 4.3 57.4 1.0
CD A:GLN58 4.4 61.6 1.0
CA A:GLU61 4.5 57.7 1.0
N A:VAL60 4.5 57.6 1.0
C A:VAL60 4.5 57.4 1.0
CA A:VAL60 4.5 57.5 1.0
O A:PHE55 4.5 57.4 1.0
CG A:PHE55 4.6 56.0 1.0
CG A:GLN58 4.6 60.5 1.0
CA A:GLN58 4.7 58.8 1.0
CG1 A:VAL60 4.7 56.0 1.0
CG2 A:VAL60 4.8 56.6 1.0
C A:GLN58 4.8 58.5 1.0
C A:PHE55 4.9 57.3 1.0

Chlorine binding site 4 out of 5 in 2vps

Go back to Chlorine Binding Sites List in 2vps
Chlorine binding site 4 out of 5 in the Structure of the Bifunctional Leishmania Major Trypanothione Synthetase-Amidase


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 4 of Structure of the Bifunctional Leishmania Major Trypanothione Synthetase-Amidase within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl1656

b:52.4
occ:1.00
 NH1 A:ARG315 3.2 51.5 1.0
N A:PRO312 3.6 60.0 1.0
CD A:PRO312 3.7 59.8 1.0
CD A:ARG315 3.8 53.9 1.0
CB A:TRP311 3.9 60.3 1.0
CG A:PRO312 3.9 60.2 1.0
CA A:PRO312 4.0 60.0 1.0
C A:TRP311 4.0 60.0 1.0
CZ A:ARG315 4.3 52.1 1.0
O A:TRP311 4.4 60.4 1.0
NE A:ARG315 4.5 53.4 1.0
CB A:PRO312 4.5 60.2 1.0
CA A:TRP311 4.6 60.2 1.0

Chlorine binding site 5 out of 5 in 2vps

Go back to Chlorine Binding Sites List in 2vps
Chlorine binding site 5 out of 5 in the Structure of the Bifunctional Leishmania Major Trypanothione Synthetase-Amidase


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 5 of Structure of the Bifunctional Leishmania Major Trypanothione Synthetase-Amidase within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl1659

b:37.6
occ:1.00
 NH2 A:ARG197 3.7 74.5 1.0
CD A:PRO202 4.0 67.8 1.0
CB A:ALA201 4.5 69.0 1.0
CG A:PRO202 4.6 67.4 1.0
NH1 A:ARG197 4.6 73.1 1.0
CZ A:ARG197 4.6 73.9 1.0

Reference:

P.K.Fyfe, S.L.Oza, A.H.Fairlamb, W.N.Hunter. Leishmania Trypanothione Synthetase-Amidase Structure Reveals A Basis For Regulation of Conflicting Synthetic and Hydrolytic Activities. J.Biol.Chem. V. 283 17672 2008.
ISSN: ISSN 0021-9258
PubMed: 18420578
DOI: 10.1074/JBC.M801850200
Page generated: Fri Jul 11 00:57:18 2025

Last articles

Fe in 2YXO
Fe in 2YRS
Fe in 2YXC
Fe in 2YNM
Fe in 2YVJ
Fe in 2YP1
Fe in 2YU2
Fe in 2YU1
Fe in 2YQB
Fe in 2YOO
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy