Chlorine in PDB 2vr2: Human Dihydropyrimidinase

All present enzymatic activity of Human Dihydropyrimidinase:
3.5.2.2;

The structure of Human Dihydropyrimidinase, PDB code: 2vr2 was solved by M.Welin, T.Karlberg, J.Andersson, C.H.Arrowsmith, H.Berglund, R.D.Busam, R.Collins, L.G.Dahlgren, A.M.Edwards, S.Flodin, A.Flores, S.Graslund, M.Hammarstrom, M.D.Herman, I.Johansson, A.Kallas, T.Kotenyova, L.Lehtio, M.Moche, M.E.Nilsson, T.Nyman, C.Persson, J.Sagemark, L.Svensson, A.G.Thorsell, L.Tresaugues, S.Van Den Berg, J.Weigelt, M.Wikstrom, P.Nordlund, Structural Genomics Consortium (Sgc), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	19.95 / 2.80
Space group	P 64 2 2
Cell size a, b, c (Å), α, β, γ (°)	89.650, 89.650, 219.100, 90.00, 90.00, 120.00
R / Rfree (%)	20 / 25.1

The structure of Human Dihydropyrimidinase also contains other interesting chemical elements:

Zinc

(Zn)

2 atoms

The binding sites of Chlorine atom in the Human Dihydropyrimidinase (pdb code 2vr2). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Human Dihydropyrimidinase, PDB code: 2vr2:

Chlorine binding site 1 out of 1 in the Human Dihydropyrimidinase


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Human Dihydropyrimidinase within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1496 b:86.2 occ:1.00 NZ A:LYS88 3.1 60.1 1.0 CE1 A:PHE453 3.7 60.6 1.0 NE2 A:GLN85 3.9 60.1 1.0 CE A:LYS88 4.0 60.6 1.0 CD2 A:HIS420 4.1 56.1 1.0 CD1 A:PHE453 4.3 60.7 1.0 CZ A:PHE453 4.6 60.7 1.0 CB A:HIS420 4.7 56.2 1.0 CG A:HIS420 4.7 56.0 1.0 CD A:GLN85 4.8 60.2 1.0 OE1 A:GLN85 4.9 60.3 1.0 O A:HIS420 4.9 56.4 1.0 CA A:HIS420 5.0 56.3 1.0

M.Welin, T.Karlberg, J.Andersson, C.H.Arrowsmith, H.Berglund, R.D.Busam, R.Collins, L.G.Dahlgren, A.M.Edwards, S.Flodin, A.Flores, S.Graslund, M.Hammarstrom, M.D.Herman, I.Johansson, A.Kallas, T.Kotenyova, L.Lehtio, M.Moche, M.E.Nilsson, T.Nyman, C.Persson, J.Sagemark, L.Svensson, A.G.Thorsell, L.Tresaugues, S.Van Den Berg, J.Weigelt, M.Wikstrom, P.Nordlund. The Crystal Structure of Human Dihydropyrimidinase To Be Published.