Chlorine in PDB 2w44: Structure DELTAA1-A4 Insulin

The structure of Structure DELTAA1-A4 Insulin, PDB code: 2w44 was solved by K.S.Thorsoee, M.Schlein, J.Brandt, G.Schluckebier, H.Naver, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	28.34 / 2.00
Space group	C 2 2 21
Cell size a, b, c (Å), α, β, γ (°)	41.050, 88.620, 73.760, 90.00, 90.00, 90.00
R / Rfree (%)	20.5 / 25.8

The structure of Structure DELTAA1-A4 Insulin also contains other interesting chemical elements:

Zinc

(Zn)

1 atom

The binding sites of Chlorine atom in the Structure DELTAA1-A4 Insulin (pdb code 2w44). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Structure DELTAA1-A4 Insulin, PDB code: 2w44:

Chlorine binding site 1 out of 1 in the Structure DELTAA1-A4 Insulin


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Structure DELTAA1-A4 Insulin within 5.0Å range: probe atom residue distance (Å) B Occ B:Cl1031 b:38.3 occ:1.00 ZN B:ZN1030 2.1 29.4 1.0 NE2 D:HIS10 3.3 19.5 1.0 NE2 B:HIS10 3.4 20.7 1.0 NE2 F:HIS10 3.5 20.4 1.0 CD2 B:HIS10 3.8 20.2 1.0 CD2 F:HIS10 4.0 18.9 1.0 CD2 D:HIS10 4.0 19.4 1.0 CB F:LEU6 4.0 22.8 1.0 CB D:LEU6 4.0 24.8 1.0 CB B:LEU6 4.2 24.2 1.0 CD1 D:LEU6 4.2 26.9 1.0 CE1 D:HIS10 4.3 23.3 1.0 CD1 F:LEU6 4.4 18.9 1.0 CE1 F:HIS10 4.5 22.5 1.0 CD1 B:LEU6 4.6 25.3 1.0 CE1 B:HIS10 4.6 24.8 1.0 CG D:LEU6 4.7 27.9 1.0 O B:LEU6 4.8 22.4 1.0 C B:LEU6 4.8 24.6 1.0 CG F:LEU6 4.9 22.3 1.0 O F:LEU6 4.9 24.5 1.0 C F:LEU6 4.9 23.9 1.0

K.S.Thorsoe, M.Schlein, D.B.Steensgaard, J.Brandt, G.Schluckebier, H.Naver. Kinetic Evidence For the Sequential Association of Insulin Binding Sites 1 and 2 to the Insulin Receptor and the Influence of Receptor Isoform. Biochemistry V. 49 6234 2010.
ISSN: ISSN 0006-2960
PubMed: 20568733
DOI: 10.1021/BI1000118