Chlorine in PDB 2w7t: Trypanosoma Brucei Ctps - Glutaminase Domain with Bound Acivicin

All present enzymatic activity of Trypanosoma Brucei Ctps - Glutaminase Domain with Bound Acivicin:
6.3.4.2;

The structure of Trypanosoma Brucei Ctps - Glutaminase Domain with Bound Acivicin, PDB code: 2w7t was solved by M.Welin, M.Moche, C.H.Arrowsmith, H.Berglund, C.Bountra, R.Collins, L.G.Dahlgren, A.M.Edwards, S.Flodin, A.Flores, S.Graslund, M.Hammarstrom, A.Johansson, I.Johansson, T.Karlberg, T.Kotenyova, L.Lehtio, M.E.Nilsson, T.Nyman, C.Persson, J.Sagemark, H.Schueler, M.I.Siponen, A.G.Thorsell, L.Tresaugues, S.Van Den Berg, J.Weigelt, M.Wikstrom, M.Wisniewska, P.Nordlund, Structural Genomics Consortium (Sgc), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	19.78 / 2.10
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	50.480, 63.680, 76.580, 90.00, 90.00, 90.00
R / Rfree (%)	19.9 / 26.2

The binding sites of Chlorine atom in the Trypanosoma Brucei Ctps - Glutaminase Domain with Bound Acivicin (pdb code 2w7t). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total 2 binding sites of Chlorine where determined in the Trypanosoma Brucei Ctps - Glutaminase Domain with Bound Acivicin, PDB code: 2w7t:
Jump to Chlorine binding site number: 1; 2;

Chlorine binding site 1 out of 2 in the Trypanosoma Brucei Ctps - Glutaminase Domain with Bound Acivicin


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Trypanosoma Brucei Ctps - Glutaminase Domain with Bound Acivicin within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1588 b:12.5 occ:1.00 O A:HOH2089 3.0 12.0 1.0 NZ A:LYS485 3.1 24.3 1.0 NH1 A:ARG541 3.3 14.5 1.0 CE A:LYS485 3.7 21.2 1.0 CD1 A:PHE542 3.7 8.0 1.0 CE1 A:PHE542 3.9 7.8 1.0 NH2 A:ARG541 4.0 17.7 1.0 CZ A:ARG541 4.1 15.9 1.0 CG1 A:ILE482 4.3 10.1 1.0 CG2 A:ILE482 4.3 8.6 1.0 CB A:SER565 4.6 9.8 1.0 CD1 A:ILE482 4.6 9.4 1.0 CB A:ILE482 4.8 10.0 1.0 O A:HOH2091 4.9 12.6 1.0 O A:SER565 5.0 8.8 1.0 CG A:PHE542 5.0 9.1 1.0

Chlorine binding site 2 out of 2 in the Trypanosoma Brucei Ctps - Glutaminase Domain with Bound Acivicin


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 2 of Trypanosoma Brucei Ctps - Glutaminase Domain with Bound Acivicin within 5.0Å range: probe atom residue distance (Å) B Occ A:Cl1589 b:28.9 occ:1.00 NZ A:LYS401 3.1 15.5 1.0 OG A:SER366 3.3 12.6 1.0 NH2 A:ARG396 3.3 30.3 1.0 NE A:ARG396 3.4 31.9 1.0 O A:GLY331 3.4 21.7 1.0 CE A:LYS401 3.4 13.7 1.0 C A:GLY331 3.5 22.8 1.0 CA A:GLY331 3.6 21.2 1.0 CG A:LYS332 3.7 26.6 1.0 CZ A:ARG396 3.8 30.7 1.0 O A:HOH2016 3.9 44.0 1.0 O A:ARG396 3.9 26.0 1.0 N A:LYS332 4.3 24.8 1.0 CB A:SER366 4.3 13.0 1.0 CD A:LYS332 4.4 27.5 1.0 CD A:ARG396 4.5 30.9 1.0 C A:ARG396 4.7 26.6 1.0 CB A:ARG396 4.8 29.5 1.0 CE A:LYS332 4.9 28.5 1.0 N A:GLY331 4.9 19.7 1.0 CB A:LYS332 4.9 26.5 1.0 CD A:LYS401 5.0 11.8 1.0 OH A:TYR341 5.0 27.8 1.0 CA A:LYS332 5.0 26.5 1.0

M.Welin, M.Moche, C.H.Arrowsmith, H.Berglund, C.Bountra, R.Collins, L.G.Dahlgren, A.M.Edwards, S.Flodin, A.Flores, S.Graslund, M.Hammarstrom, A.Johansson, I.Johansson, T.Karlberg, T.Kotenyova, L.Lehtio, M.E.Nilsson, T.Nyman, C.Persson, J.Sagemark, H.Schueler, M.I.Siponen, A.G.Thorsell, L.Tresaugues, S.Van Den Berg, J.Weigelt, M.Wikstrom, M.Wisniewska, P.Nordlund, Structural Genomics Consortium (Sgc). Trypanosoma Brucei Ctps - Glutaminase Domain with Bound Acivicin To Be Published.