Atomistry » Chlorine » PDB 2w26-2wcg » 2wap
Atomistry »
  Chlorine »
    PDB 2w26-2wcg »
      2wap »

Chlorine in PDB 2wap: 3D-Crystal Structure of Humanized-Rat Fatty Acid Amide Hydrolase (Faah) Conjugated with the Drug-Like Urea Inhibitor Pf-3845

Enzymatic activity of 3D-Crystal Structure of Humanized-Rat Fatty Acid Amide Hydrolase (Faah) Conjugated with the Drug-Like Urea Inhibitor Pf-3845

All present enzymatic activity of 3D-Crystal Structure of Humanized-Rat Fatty Acid Amide Hydrolase (Faah) Conjugated with the Drug-Like Urea Inhibitor Pf-3845:
3.5.1.4;

Protein crystallography data

The structure of 3D-Crystal Structure of Humanized-Rat Fatty Acid Amide Hydrolase (Faah) Conjugated with the Drug-Like Urea Inhibitor Pf-3845, PDB code: 2wap was solved by M.Mileni, S.Kamtekar, R.C.Stevens, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 37.01 / 2.80
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 102.770, 105.200, 148.030, 90.00, 90.00, 90.00
R / Rfree (%) 19.2 / 23.2

Other elements in 2wap:

The structure of 3D-Crystal Structure of Humanized-Rat Fatty Acid Amide Hydrolase (Faah) Conjugated with the Drug-Like Urea Inhibitor Pf-3845 also contains other interesting chemical elements:

Fluorine (F) 6 atoms
Sodium (Na) 3 atoms

Chlorine Binding Sites:

The binding sites of Chlorine atom in the 3D-Crystal Structure of Humanized-Rat Fatty Acid Amide Hydrolase (Faah) Conjugated with the Drug-Like Urea Inhibitor Pf-3845 (pdb code 2wap). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the 3D-Crystal Structure of Humanized-Rat Fatty Acid Amide Hydrolase (Faah) Conjugated with the Drug-Like Urea Inhibitor Pf-3845, PDB code: 2wap:

Chlorine binding site 1 out of 1 in 2wap

Go back to Chlorine Binding Sites List in 2wap
Chlorine binding site 1 out of 1 in the 3D-Crystal Structure of Humanized-Rat Fatty Acid Amide Hydrolase (Faah) Conjugated with the Drug-Like Urea Inhibitor Pf-3845


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of 3D-Crystal Structure of Humanized-Rat Fatty Acid Amide Hydrolase (Faah) Conjugated with the Drug-Like Urea Inhibitor Pf-3845 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl1575

b:23.1
occ:1.00
ND2 A:ASN259 3.2 31.1 1.0
ND2 B:ASN259 3.4 33.2 1.0
CZ2 B:TRP556 3.6 31.4 1.0
CZ2 A:TRP556 3.8 33.4 1.0
CH2 B:TRP556 3.9 32.0 1.0
CH2 A:TRP556 4.0 33.3 1.0
CB B:ASN259 4.3 33.7 1.0
CG A:ASN259 4.3 33.5 1.0
CG B:ASN259 4.3 34.0 1.0
CB A:ASN259 4.4 33.8 1.0
CG B:PRO310 4.5 32.4 1.0
CD B:PRO310 4.6 32.6 1.0
CG A:PRO310 4.7 33.0 1.0
CD A:PRO310 4.7 33.1 1.0
CE2 B:TRP556 4.8 31.5 1.0
CE2 A:TRP556 5.0 33.0 1.0

Reference:

K.Ahn, D.S.Johnson, M.Mileni, D.Beidler, J.Z.Long, M.K.Mckinney, E.Weerapana, N.Sadagopan, M.Liimatta, S.E.Smith, S.Lazerwith, C.Stiff, S.Kamtekar, K.Bhattacharya, Y.Zhang, S.Swaney, K.Vanbecelaere, R.C.Stevens, B.F.Cravatt. Discovery and Characterization of A Highly Selective Faah Inhibitor That Reduces Inflammatory Pain. Chem.Biol. V. 16 411 2009.
ISSN: ISSN 1074-5521
PubMed: 19389627
DOI: 10.1016/J.CHEMBIOL.2009.02.013
Page generated: Sat Dec 12 09:22:40 2020

Last articles

Zn in 8WB0
Zn in 8WAX
Zn in 8WAU
Zn in 8WAZ
Zn in 8WAY
Zn in 8WAV
Zn in 8WAW
Zn in 8WAT
Zn in 8W7M
Zn in 8WD3
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy