Atomistry » Chlorine » PDB 2wcz-2wjp » 2wj1
Atomistry »
  Chlorine »
    PDB 2wcz-2wjp »
      2wj1 »

Chlorine in PDB 2wj1: 3D-Crystal Structure of Humanized-Rat Fatty Acid Amide Hydrolase (Faah) Conjugated with 7-Phenyl-1-(4-(Pyridin-2- Yl)Oxazol-2-Yl)Heptan-1-One, An Alpha-Ketooxazole

Enzymatic activity of 3D-Crystal Structure of Humanized-Rat Fatty Acid Amide Hydrolase (Faah) Conjugated with 7-Phenyl-1-(4-(Pyridin-2- Yl)Oxazol-2-Yl)Heptan-1-One, An Alpha-Ketooxazole

All present enzymatic activity of 3D-Crystal Structure of Humanized-Rat Fatty Acid Amide Hydrolase (Faah) Conjugated with 7-Phenyl-1-(4-(Pyridin-2- Yl)Oxazol-2-Yl)Heptan-1-One, An Alpha-Ketooxazole:
3.5.1.4;

Protein crystallography data

The structure of 3D-Crystal Structure of Humanized-Rat Fatty Acid Amide Hydrolase (Faah) Conjugated with 7-Phenyl-1-(4-(Pyridin-2- Yl)Oxazol-2-Yl)Heptan-1-One, An Alpha-Ketooxazole, PDB code: 2wj1 was solved by M.Mileni, J.Garfunkle, J.K.Demartino, B.F.Cravatt, D.L.Boger, R.C.Stevens, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 36.306 / 1.84
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 75.830, 106.210, 79.390, 90.00, 100.20, 90.00
R / Rfree (%) 18.58 / 21.42

Chlorine Binding Sites:

The binding sites of Chlorine atom in the 3D-Crystal Structure of Humanized-Rat Fatty Acid Amide Hydrolase (Faah) Conjugated with 7-Phenyl-1-(4-(Pyridin-2- Yl)Oxazol-2-Yl)Heptan-1-One, An Alpha-Ketooxazole (pdb code 2wj1). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the 3D-Crystal Structure of Humanized-Rat Fatty Acid Amide Hydrolase (Faah) Conjugated with 7-Phenyl-1-(4-(Pyridin-2- Yl)Oxazol-2-Yl)Heptan-1-One, An Alpha-Ketooxazole, PDB code: 2wj1:

Chlorine binding site 1 out of 1 in 2wj1

Go back to Chlorine Binding Sites List in 2wj1
Chlorine binding site 1 out of 1 in the 3D-Crystal Structure of Humanized-Rat Fatty Acid Amide Hydrolase (Faah) Conjugated with 7-Phenyl-1-(4-(Pyridin-2- Yl)Oxazol-2-Yl)Heptan-1-One, An Alpha-Ketooxazole


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of 3D-Crystal Structure of Humanized-Rat Fatty Acid Amide Hydrolase (Faah) Conjugated with 7-Phenyl-1-(4-(Pyridin-2- Yl)Oxazol-2-Yl)Heptan-1-One, An Alpha-Ketooxazole within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cl1578

b:28.8
occ:1.00
 O A:HOH2110 3.1 30.7 1.0
O A:HOH2046 3.1 26.9 1.0
ND2 A:ASN259 3.6 22.8 1.0
ND2 B:ASN259 3.6 25.1 1.0
CZ2 A:TRP556 3.8 17.8 1.0
CZ2 B:TRP556 3.9 19.8 1.0
CH2 A:TRP556 4.0 20.3 1.0
CH2 B:TRP556 4.1 18.7 1.0
CG A:PRO310 4.3 29.7 1.0
CB A:ASN259 4.3 16.1 1.0
CB B:ASN259 4.4 15.9 1.0
CG A:ASN259 4.5 28.6 1.0
CG B:ASN259 4.5 31.3 1.0
CG B:PRO310 4.7 20.1 1.0
CD A:PRO310 4.7 16.1 1.0
CD B:PRO310 4.8 14.3 1.0

Reference:

M.Mileni, J.Garfunkle, J.K.Demartino, B.F.Cravatt, D.L.Boger, R.C.Stevens. Binding and Inactivation Mechanism of A Humanized Fatty Acid Amide Hydrolase By Alpha- Ketoheterocycle Inhibitors Revealed From Cocrystal Structures. J.Am.Chem.Soc. V. 131 10497 2009.
ISSN: ISSN 0002-7863
PubMed: 19722626
DOI: 10.1021/JA902694N
Page generated: Sat Jul 20 12:57:34 2024

Last articles

Zn in 9J0N
Zn in 9J0O
Zn in 9J0P
Zn in 9FJX
Zn in 9EKB
Zn in 9C0F
Zn in 9CAH
Zn in 9CH0
Zn in 9CH3
Zn in 9CH1
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy