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Chlorine in PDB 2wns: Human Orotate Phosphoribosyltransferase (Oprtase) Domain of Uridine 5'-Monophosphate Synthase (Umps) in Complex with Its Substrate Orotidine 5'-Monophosphate (Omp)

Enzymatic activity of Human Orotate Phosphoribosyltransferase (Oprtase) Domain of Uridine 5'-Monophosphate Synthase (Umps) in Complex with Its Substrate Orotidine 5'-Monophosphate (Omp)

All present enzymatic activity of Human Orotate Phosphoribosyltransferase (Oprtase) Domain of Uridine 5'-Monophosphate Synthase (Umps) in Complex with Its Substrate Orotidine 5'-Monophosphate (Omp):
2.4.2.10;

Protein crystallography data

The structure of Human Orotate Phosphoribosyltransferase (Oprtase) Domain of Uridine 5'-Monophosphate Synthase (Umps) in Complex with Its Substrate Orotidine 5'-Monophosphate (Omp), PDB code: 2wns was solved by M.Moche, A.Roos, C.H.Arrowsmith, H.Berglund, C.Bountra, R.Collins, A.M.Edwards, S.Flodin, A.Flores, S.Graslund, M.Hammarstrom, A.Johansson, I.Johansson, T.Karlberg, T.Kotyenova, A.Kotzch, T.K.Nielsen, T.Nyman, C.Persson, J.Sagemark, H.Schueler, P.Schutz, M.I.Siponen, L.Svensson, A.G.Thorsell, L.Tresaugues, S.Vandenberg, J.Weigelt, M.Welin, M.Wisniewska, P.Nordlund, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 37.06 / 1.90
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 64.400, 43.600, 71.000, 90.00, 113.40, 90.00
R / Rfree (%) 18.003 / 22.791

Chlorine Binding Sites:

The binding sites of Chlorine atom in the Human Orotate Phosphoribosyltransferase (Oprtase) Domain of Uridine 5'-Monophosphate Synthase (Umps) in Complex with Its Substrate Orotidine 5'-Monophosphate (Omp) (pdb code 2wns). This binding sites where shown within 5.0 Angstroms radius around Chlorine atom.
In total only one binding site of Chlorine was determined in the Human Orotate Phosphoribosyltransferase (Oprtase) Domain of Uridine 5'-Monophosphate Synthase (Umps) in Complex with Its Substrate Orotidine 5'-Monophosphate (Omp), PDB code: 2wns:

Chlorine binding site 1 out of 1 in 2wns

Go back to Chlorine Binding Sites List in 2wns
Chlorine binding site 1 out of 1 in the Human Orotate Phosphoribosyltransferase (Oprtase) Domain of Uridine 5'-Monophosphate Synthase (Umps) in Complex with Its Substrate Orotidine 5'-Monophosphate (Omp)


Mono view


Stereo pair view

A full contact list of Chlorine with other atoms in the Cl binding site number 1 of Human Orotate Phosphoribosyltransferase (Oprtase) Domain of Uridine 5'-Monophosphate Synthase (Umps) in Complex with Its Substrate Orotidine 5'-Monophosphate (Omp) within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cl1208

b:14.0
occ:1.00
 OG1 A:THR83 3.0 12.6 1.0
OG1 B:THR83 3.1 9.1 1.0
O B:HOH2006 3.1 13.9 1.0
O A:HOH2028 3.1 12.6 1.0
CA B:PRO80 3.6 12.9 1.0
CA A:PRO80 3.7 13.2 1.0
CB B:THR83 3.7 13.7 1.0
CB A:THR83 3.7 11.3 1.0
N B:PRO80 3.8 13.2 1.0
O A:LEU79 3.9 14.2 1.0
N A:PRO80 3.9 13.7 1.0
O B:LEU79 4.0 14.5 1.0
C B:LEU79 4.0 14.0 1.0
C A:LEU79 4.0 13.6 1.0
CB B:PRO80 4.1 12.0 1.0
CG2 B:THR83 4.2 12.9 1.0
CG2 A:THR83 4.2 9.1 1.0
CB A:PRO80 4.3 13.2 1.0
CD B:PRO80 4.4 12.8 1.0
CG A:PRO80 4.4 14.6 1.0
CG B:PRO80 4.5 14.0 1.0
CD A:PRO80 4.5 13.3 1.0
O B:HOH2022 4.5 14.5 1.0
O B:HOH2029 4.6 24.9 1.0
O A:HOH2050 4.6 12.1 1.0
CB B:LEU79 4.7 14.6 1.0
CB A:LEU79 4.7 14.3 1.0
O A:HOH2061 4.8 20.9 1.0
C B:PRO80 4.8 13.3 1.0
C A:PRO80 4.8 13.6 1.0
CA B:LEU79 5.0 14.4 1.0

Reference:

M.Moche, A.Roos, C.H.Arrowsmith, H.Berglund, C.Bountra, R.Collins, A.M.Edwards, S.Flodin, A.Flores, S.Graslund, M.Hammarstrom, A.Johansson, I.Johansson, T.Karlberg, T.Kotyenova, A.Kotzch, T.K.Nielsen, T.Nyman, C.Persson, J.Sagemark, H.Schueler, P.Schutz, M.I.Siponen, L.Svensson, A.G.Thorsell, L.Tresaugues, S.Vandenberg, J.Weigelt, M.Welin, M.Wisniewska, P.Nordlund. Human Orotate Phosphoribosyltransferase (Oprtase) Domain of Uridine 5'-Monophosphate Synthase (Umps) in Complex with Its Substrate Orotidine 5'- Monophosphate (Omp) To Be Published.
Page generated: Sat Jul 20 13:03:20 2024

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